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Results for "

ROS+formation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Angiotensin Receptor (3) Apoptosis (16) Autophagy (1) Bcl-2 Family (1) Calcium Channel (2) Carnitine Palmitoyltransferase (CPT) (1) Caspase (2) Drug Derivative (1) Drug Metabolite (3) Endogenous Metabolite (2) Environmental Pollutants (1) ERK (2) Ferroptosis (1) Glutathione Peroxidase (1) Hexokinase (1) Interleukin Related (1) Mitochondrial Metabolism (2) Nuclear Hormone Receptor 4A/NR4A (1) Oxidative Phosphorylation (1) p38 MAPK (2) PARP (1) PKA (5) Quinone Reductase (2) Reactive Oxygen Species (ROS) (19) Reference Standards (4) Transferrin Receptor (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (8)

By Targets:

Amyloid-β (1)

Angiotensin Receptor (3)

Apoptosis (16)

Autophagy (1)

Bcl-2 Family (1)

Calcium Channel (2)

Carnitine Palmitoyltransferase (CPT) (1)

Caspase (2)

Drug Derivative (1)

Drug Metabolite (3)

Endogenous Metabolite (2)

Environmental Pollutants (1)

ERK (2)

Ferroptosis (1)

Glutathione Peroxidase (1)

Hexokinase (1)

Interleukin Related (1)

Mitochondrial Metabolism (2)

Nuclear Hormone Receptor 4A/NR4A (1)

Oxidative Phosphorylation (1)

p38 MAPK (2)

PARP (1)

PKA (5)

Quinone Reductase (2)

Reactive Oxygen Species (ROS) (19)

Reference Standards (4)

Transferrin Receptor (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (4)

Endocrinology (1)

Inflammation/Immunology (8)

Metabolic Disease (4)

Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0764

Bucladesine sodium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-19992

3-Bromopyruvic acid 30+ Cited Publications Bromopyruvic acid; 3-BrPA; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-135897

Urolithin C 5 Publications Verification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-B0764A

Bucladesine hemicalcium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium	PKA Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-14914

Azilsartan 5+ Cited Publications TAK-536	Angiotensin Receptor Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces *ROS* formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Environmental Pollutants Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of *ROS* formation .

HY-W050000

OR-1855 1 Publications Verification	Drug Metabolite Reactive Oxygen Species (ROS) ERK p38 MAPK	Cardiovascular Disease Inflammation/Immunology
OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced *ROS* formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .

HY-108992

Deoxynyboquinone	Quinone Reductase Apoptosis Reactive Oxygen Species (ROS)	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-B0764B

Bucladesine Dibutyryl cAMP; DBcAMP	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-175673

LCB-2151	Carnitine Palmitoyltransferase (CPT) Apoptosis Oxidative Phosphorylation Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Cancer
LCB-2151 (Compound 2), a nucleoside analogue, is an anticancer agent. LCB-2151 disrupts the two primary sources of ATP production (glycolysis and mitochondrial oxidative phosphorylation), reducing the bioenergetic capacity of KRAS-mutated pancreatic cancer cells and inducing ROS formation. LCB-2151 effectively inhibits key enzymes (such as CACT and CPT2) in glycolysis, the TCA cycle and fatty acid β-oxidation. LCB-2151 has significant cytotoxicity and induces cells apoptosis. LCB-2151 can be used for radiation therapy of cancers research .

HY-B0764R

Bucladesine sodium (Standard) Dibutyryl cAMP sodium (Standard); DBcAMP sodium (Standard)	Reference Standards PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (Standard) is the analytical standard of Bucladesine sodiumn (HY-B0764). This product is intended for research and analytical applications. Bucladesine is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial *ROS* formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-14914S1

Azilsartan-d4 TAK-536-d₄	Apoptosis Angiotensin Receptor Reactive Oxygen Species (ROS)	Cancer
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-143413

BuChE-IN-2	Amyloid-β	Neurological Disease Inflammation/Immunology
BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC₅₀s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu ²⁺, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease .

HY-14914R

Azilsartan (Standard) TAK-536 (Standard)	Reference Standards Angiotensin Receptor Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Azilsartan (Standard) is the analytical standard of Azilsartan. This product is intended for research and analytical applications. Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces *ROS* formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-135897R

Urolithin C (Standard)	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C (Standard) is the analytical standard of Urolithin C. This product is intended for research and analytical applications. Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-W050000R

OR-1855 (Standard)	Drug Metabolite Reference Standards Reactive Oxygen Species (ROS) ERK p38 MAPK	Cardiovascular Disease Inflammation/Immunology
OR-1855 (Standard) is an analytical standard of OR-1855 (HY-W050000). This product is intended for research and analytical applications. OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced *ROS* formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .

HY-108992R

Deoxynyboquinone (Standard)	Quinone Reductase Reference Standards Apoptosis Reactive Oxygen Species (ROS)	Cancer
Deoxynyboquinone (Standard) is the analytical standard of Deoxynyboquinone (HY-108992). This product is intended for research and analytical applications. Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone K_ills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-148965A

PtdIns-(3)-P1 (1,2-dipalmitoyl) ammonium DPPI-3-P ammonium; PIP[3'](16:0/16:0) ammonium; PI(3)P (16:0/16:0) ammonium	Drug Derivative Reactive Oxygen Species (ROS)	Others
PtdIns-(3)-P1 (1,2-dipalmitoyl) (Compound 7) ammonium is a derivative of phosphatidylinositol 3-phosphate (PtdIns(3)P). phosphatidylinositol 3-phosphate can bind to the FYVE domain of human EEA1 and act as a second messenger in cellular signaling and membrane trafficking. phosphatidylinositol 3-phosphate can stimulate *ROS* formation by regulating the neutrophil oxidase complex .

HY-N17653

13'-Carboxy-δ-tocopherol	Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS) Caspase PARP Drug Metabolite	Cancer
13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases *ROS* formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma .

HY-179528

DIM-3,5-Cl2	Nuclear Hormone Receptor 4A/NR4A Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) Transferrin Receptor Apoptosis Bcl-2 Family Caspase	Endocrinology Cancer
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K_D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively. DIM-3,5-Cl2 acts as an inverse agonist to downregulate pro-oncogenic and proendometriotic gene products, and as an agonist to enhance NR4A1/2/Sp1/Sp4-mediated CD71 transactivation. DIM-3,5-Cl2 induces ferroptosis via *ROS* formation, lipoperoxidation, MDA production, and reduced GPX4, SLC7A11 expression. DIM-3,5-Cl2 induces apoptosis via PARP and caspase-3 cleavage, reduced BCL-2 expression, and inhibits cancer cell viability. DIM-3,5-Cl2 can be used for the research of triple negative breast cancer, endometriosis, and colorectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure