RPA

By Targets:	Apoptosis (1) DNA/RNA Synthesis (2) Parasite (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS12142

RPA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for RPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPA1 Human Pre-designed siRNA Set A RPA1 Human Pre-designed siRNA Set A

HY-RS12143

RPA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPA2 Human Pre-designed siRNA Set A contains three designed siRNAs for RPA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPA2 Human Pre-designed siRNA Set A RPA2 Human Pre-designed siRNA Set A

HY-RS12144

RPA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPA3 Human Pre-designed siRNA Set A contains three designed siRNAs for RPA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPA3 Human Pre-designed siRNA Set A RPA3 Human Pre-designed siRNA Set A

HY-RS12145

RPA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPA4 Human Pre-designed siRNA Set A contains three designed siRNAs for RPA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPA4 Human Pre-designed siRNA Set A RPA4 Human Pre-designed siRNA Set A

HY-145896

Anti-osteoporosis agent-1

Apoptosis Inflammation/Immunology

Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC₅₀=18 µM) .

Anti-osteoporosis agent-1	Apoptosis	Inflammation/Immunology
Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A *(RPA)* inhibitor (IC₅₀=18 µM) .

HY-114842

TDRL-551	Others	Cancer
TDRL-551 is a potent replication protein A *(RPA)* inhibitor (IC₅₀=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation .

HY-E70216

Bsu DNA polymerase, Large fragment	Others	Others
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .

HY-138155

NSC15520	Others	Cancer
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the *RPA* N-terminal DNA binding domain (DBD), and blocks the interaction of *RPA* with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling .

HY-111285

HAMNO

NSC111847
Others Cancer

HAMNO is a novel protein interaction inhibitor of replication protein A (RPA).

HAMNO NSC111847	Others	Cancer
HAMNO is a novel protein interaction inhibitor of replication protein A (RPA).

HY-122198

ML367	Others	Cancer
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation .

HY-145840

Pol I-IN-1

DNA/RNA Synthesis Cancer

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC₅₀ 0.21 µM for the Pol I large catalytic subunit RPA194 .
HY-D0928

Sudan II

Sudan orange RPA; Sudan red II

Sudan Red II is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
HY-155655

JC-229

Parasite Infection

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

Pol I-IN-1	DNA/RNA Synthesis	Cancer
Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC₅₀ 0.21 µM for the Pol I large catalytic subunit RPA194 .

Sudan II Sudan orange RPA; Sudan red II
Sudan Red II is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-118723

BMH-22	DNA/RNA Synthesis	Cancer
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .

Species:	Rat (1) Canine (2)
Tag:	His (2) Fc (1)
Source:	HEK293 (1) P. pastoris (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75965

	PDGFAA Protein, Canine (P.pastoris, His) Platelet-derived growth factor subunit A; PDGF-1; PDGF-A; RPA1	Canine	P. pastoris
	PDGFAA Protein is platelet-derived growth factor subunit A precursor. PDGFAA Protein, Canine (P.pastoris, His) is the recombinant canine-derived PDGFAA protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGFAA Protein, Canine (P.pastoris, His) is 110 a.a., with molecular weight of ~14.5 kDa.

HY-P75964

	PDGFAA Protein, Canine (HEK293, Fc) Platelet-derived growth factor subunit A; PDGF-1; PDGF-A; RPA1	Canine	HEK293
	PDGFAA Protein is platelet-derived growth factor subunit A precursor. PDGFAA Protein, Canine (HEK293, Fc) is the recombinant canine-derived PDGFAA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGFAA Protein, Canine (HEK293, Fc) is 110 a.a., with molecular weight of ~41 kDa.

HY-P73720

	PDGF-AA Protein, Rat (P.pastoris, His) Platelet-derived growth factor subunit A; PDGF-1; PDGF-A; RPA1	Rat	P. pastoris
	PDGF-AA protein is a key growth factor that serves as an effective mitogen for mesenchymal cells, coordinates embryonic development, and affects cell proliferation, migration, survival, and chemotaxis. It plays an important role in alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, oligodendrocyte development, and myelination of the spinal cord and cerebellum. PDGF-AA Protein, Rat (P.pastoris, His) is the recombinant rat-derived PDGF-AA protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-AA Protein, Rat (P.pastoris, His) is 110 a.a., with molecular weight of ~14.5 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80884

RPA70 Antibody (YA678) RPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70	WB, ICC/IF, IP	Human, Monkey, Mouse, Rat
RPA70 Antibody (YA678) is a non-conjugated and Mouse origined monoclonal antibody about 68 kDa, targeting to RPA70 (8C3). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Monkey, Mouse, Rat.

HY-P80975

RPA32 Antibody (YA679)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
RPA32 Antibody (YA679) is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to RPA32. It can be used for WB, IHC-P, ICC/IF, IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82975

*Phospho-RPA2 (Thr21) Antibody (YA2720)* 60S acidic ribosomal protein P1; AA409079; AI325195; AU020965; HSSB; ik:tdsubc_2g1; M(2)21C; MGC137236; OTTHUMP00000004008; p32; p34; RCJMB04_6d17 replication protein A2; 32kDa; REPA 2; REPA1; REPA2; Replication factor A protein 2; Replication protein A 32 kDa subunit; Replication protein A 32kDa subunit; Replication protein A 34 kDa subunit; Replication protein A; replication protein A1 (70kD); Replication Protein A2 (32kDa); Replication protein A2 32kD; Replication protein A2 32kDa; Replication protein A2; Replication protein A2; 32kDa; RF A; RF-A protein 2; Rf-A2; RFA; RFA2_HUMAN; RP A; RP-A p32; RP-A p34; RP21C; RPA 2; RPA 32; RPA; RPA2; RPA32; RPA34; RPA70; RpLP1; RpP2; xx:tdsubc_2g1; zgc:109822.	WB, IP	Human, Mouse, Rat

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