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Results for "

RXR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (37) Apoptosis (6) Autophagy (9) Bacterial (1) Bcl-2 Family (1) COX (1) Endogenous Metabolite (1) HCV (1) NO Synthase (1) PARP (1) PPAR (1) SphK (1) TRP Channel (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (8) Neurological Disease (9)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: RAR/RXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144377

RXR antagonist 1	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA₂ of 8.06. RXR antagonist 1 can be used for type 2 diabetes research .

HY-107399

CD3254

3 Publications Verification

RAR/RXR Metabolic Disease Cancer

CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

CD3254 3 Publications Verification	RAR/RXR	Metabolic Disease Cancer
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-162162

RXR antagonist 6	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR antagonist 6 (Compound 33) is a highly selective *RXR* agonist, with EC₅₀s of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. RXR antagonist 6 binds to RXR with high affinity (K_d = 0.03 μM) .

HY-144383

RXR antagonist 2	RAR/RXR	Others
RXR antagonist 2 (compound 6b) is a potent antagonist of *RXR* with a K_i and K_d of 0.391 and 0.281 μM. RXR antagonist 2 has the potential for the research of RXR related diseases .

HY-155437

NEt-iFQ

RAR/RXR Others

NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-14171

Bexarotene Maximum Cited Publications 16 Publications Verification LGD1069	RAR/RXR Autophagy	Cancer
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-108522

PA452 1 Publications Verification	RAR/RXR	Metabolic Disease
PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development .

HY-108523

LG100754 UVI 2112	RAR/RXR	Metabolic Disease
LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a *RXR:RXR* homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .

HY-15340

LG100268 2 Publications Verification LG268	RAR/RXR Autophagy	Metabolic Disease
LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC₅₀ values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the K_i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-104070

LG-100064	RAR/RXR Autophagy	Cancer
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-107413

SR11237 BMS-649	RAR/RXR	Cancer
SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element .

HY-108525

Fluorobexarotene	RAR/RXR	Cancer
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .

HY-13717

AGN194204 IRX4204; NRX194204; VTP 194204	RAR/RXR Apoptosis	Inflammation/Immunology Cancer
AGN194204 (IRX4204) is an orally active and selective *RXR* agonist with K_d values 0.4 nM, 3.6 nM and 3.8 nM and EC₅₀s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions .

HY-108524

LG101506	RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
LG101506 is a selective and orally active *RXR* modulator with a K_i of 2.7 nM for RXRα. LG101506 can be used for the research of type 2 diabetes and cancer .

HY-107500

UVI 3003 3 Publications Verification	RAR/RXR Autophagy	Others
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

HY-149085

XS-060

RAR/RXR Cancer

XS-060 is a potent anticancer agent and RXRα antagonist. XS-060 significantly induces RXRα-dependent mitotic arrest by inhibiting pRXRα-PLK1 interaction .

XS-060	RAR/RXR	Cancer
XS-060 is a potent anticancer agent and RXRα antagonist. XS-060 significantly induces RXRα-dependent mitotic arrest by inhibiting pRXRα-PLK1 interaction .

HY-107436

LE135 1 Publications Verification	RAR/RXR TRP Channel	Neurological Disease Cancer
LE135 is a potent RAR antagonist that binds selectively to RARα (K_i of 1.4 μM) and RARβ (K_i of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC₅₀s of 2.5 μM and 20 μM, respectively .

HY-153980

K-80001	RAR/RXR COX	Inflammation/Immunology
K-80001 is an RXRα-binder and COX-1/2 inhibitor, with IC₅₀s of with an IC₅₀ of 82.9μM, 3.4μM, 1.2μM for RXRα, COX-1 and COX-2, respectively .

HY-N2992

16α-Hydroxytrametenolic acid

RAR/RXR Cancer

16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

16α-Hydroxytrametenolic acid	RAR/RXR	Cancer
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-149086

BPA-B9	RAR/RXR Apoptosis PARP Bcl-2 Family	Cancer
BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (K_D=39.29 ± 1.12 nM). BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis .

HY-101953

β-Apo-13-carotenone

D'Orenone
RAR/RXR Others

β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
HY-16685

AGN 205327

RAR/RXR Autophagy Cancer

AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.
HY-133739

NBD-125

RAR/RXR Cancer

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell .
HY-111573

KCL-286

RAR/RXR Others

Anticancer agent 168 is an orally active retinoic acid receptor (RAR/RXR) beta2 agonist with ameliorating effects on spinal cord injury (SCI) .
HY-108520

HX630

RAR/RXR Apoptosis Cancer

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research .

β-Apo-13-carotenone D'Orenone	RAR/RXR	Others
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.

AGN 205327	RAR/RXR Autophagy	Cancer
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.

NBD-125	RAR/RXR	Cancer
NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell .

KCL-286	RAR/RXR	Others
Anticancer agent 168 is an orally active retinoic acid receptor (RAR/RXR) beta2 agonist with ameliorating effects on spinal cord injury (SCI) .

HX630	RAR/RXR Apoptosis	Cancer
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-N0163

Magnolol 2 Publications Verification	RAR/RXR PPAR Autophagy Bacterial	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-108521

HX531	RAR/RXR	Metabolic Disease
HX531 is a potent *RXR* antagonist with an IC₅₀ of 18 nM . It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet .

HY-14171S

Bexarotene-d4 LGD1069 d₄	RAR/RXR Autophagy	Cancer
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[1][2][3][4][5].

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-10291

Tarenflurbil 2 Publications Verification (R)-Flurbiprofen; MPC7869	RAR/RXR Autophagy	Neurological Disease Inflammation/Immunology
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [ ³H]9-cis-RA to RXRα LBD with IC₅₀ of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

HY-15128

9-cis-Retinoic acid Alitretinoin	RAR/RXR Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent *RAR/RXR* agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

HY-108530

MM11253	RAR/RXR	Cancer
MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-116248

Ro 41-5253	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity .

HY-132334S

9-cis-Retinoic acid-d5	RAR/RXR Apoptosis	Neurological Disease Inflammation/Immunology Cancer
9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].

HY-100008

Peretinoin 3 Publications Verification NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-125904

4-Hydroxyretinoic acid	RAR/RXR	Neurological Disease Inflammation/Immunology Cancer
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor RAR (Retinoic Acid Receptor), and activates RARs and *RXR-alpha, to induce cancer cell apoptosis*. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2992

16α-Hydroxytrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	RAR/RXR
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-N0163

Magnolol 2 Publications Verification	Cardiovascular Disease Neurological Disease Classification of Application Fields Source classification Lignans Plants Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	RAR/RXR PPAR Autophagy Bacterial
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-15128

9-cis-Retinoic acid Alitretinoin	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	RAR/RXR Apoptosis Endogenous Metabolite
9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent *RAR/RXR* agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities .

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701402

	RXRB Protein, Human RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta	Human	E. coli
	RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human is the recombinant human-derived RXRB protein, expressed by E. coli , with tag free. The total length of RXRB Protein, Human is 235 a.a., .

HY-P701403

	RXRB Protein, Human (His) RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta	Human	E. coli
	RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human (His) is the recombinant human-derived RXRB protein, expressed by E. coli , with N-6*His labeled tag. The total length of RXRB Protein, Human (His) is 235 a.a., .

HY-P76523

	NRBF2 Protein, Human (sf9, His-GST) Nuclear receptor-binding factor 2; Comodulator of PPAR and RXR; COPR	Human	Sf9 insect cells
	NRBF2 protein may regulate transcriptional activation through target nuclear receptors and act as a transcriptional activator in vitro. It participates in starvation-induced autophagy, binding to PI3K complex I (PI3KC3-C1) and stabilizing its assembly. NRBF2 Protein, Human (sf9, His-GST) is the recombinant human-derived NRBF2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of NRBF2 Protein, Human (sf9, His-GST) is 287 a.a., with molecular weight of ~61 KDa.

Cat. No.	Product Name	Chemical Structure

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma[1][2][3][4][5].

HY-132334S

9-cis-Retinoic acid-d5
9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].

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RXR

Inhibitors & Agonists

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Recombinant Proteins

Isotope-Labeled Compounds

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