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Results for "

Reh

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Inhibitory Antibodies

1

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135231
    NL-1
    5 Publications Verification

    		 Mitochondrial Metabolism Autophagy Cancer
    NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 μM and 56.26 μM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway .
    NL-1
  • HY-10224A
    Panobinostat lactate
    80+ Cited Publications

    LBH589 lactate; NVP-LBH589 lactate

    		 HDAC HIV Autophagy Apoptosis Infection Cancer
    Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma .
    Panobinostat lactate
  • HY-148369
    U7D-1

    		PROTACs Deubiquitinase Apoptosis MDM-2/p53 Cancer
    U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC50 of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells .
    U7D-1
  • HY-P991570
    Zaptuzumab

    AD5-10; oba-01 Antibody

    		 TNF Receptor Apoptosis Caspase Atg8/LC3 Akt Beclin1 JNK Cancer
    Zaptuzumab (AD5-10) is a DR5-specific humanized monoclonal antibody that selectively binds to DR5 with high affinity. Zaptuzumab specifically induces cancer cell death by both caspase-apoptosis and autophagic cell death (ACD). Zaptuzumab activates both ADCC and CDC. Zaptuzumab induces ROS generation and GSH level reduction. Zaptuzumab shows a significant suppression of the tumor growth and good safety in various xenografts mice tumor models .
    Zaptuzumab
  • HY-159175
    XM-U-14

    		PROTACs Deubiquitinase Apoptosis MDM-2/p53 Cancer
    XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line). XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively). XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand (HY-159465), Black: linker (HY-W539783); Pink: USP7 inhibitor (HY-159464)) .
    XM-U-14
  • HY-RS07687
    LIPE Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LIPE Human Pre-designed siRNA Set A contains three designed siRNAs for LIPE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LIPE Human Pre-designed siRNA Set A
    LIPE Human Pre-designed siRNA Set A
  • HY-135901
    Py-MPB-amino-C3-PBD

    		ADC Payload Bacterial Cancer
    Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
    Py-MPB-amino-C3-PBD
  • HY-RS18621
    Lipe Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lipe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lipe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lipe Mouse Pre-designed siRNA Set A
    Lipe Mouse Pre-designed siRNA Set A
  • HY-176732
    MJ-26

    		Epigenetic Reader Domain Cancer
    MJ-26 is an inhibitor targeting Menin. MJ-26 has high binding affinity (Ki: 0.56 μM) and significant antiproliferative activity. MJ-26 works by inhibiting Menin-MLL interaction and inducing Menin protein degradation. MJ-26 has significant antitumor effects on acute myeloid leukemia (AML). MJ-26 can be used in AML research .
    MJ-26
  • HY-RS02543
    CES1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CES1 Human Pre-designed siRNA Set A contains three designed siRNAs for CES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CES1 Human Pre-designed siRNA Set A
    CES1 Human Pre-designed siRNA Set A
  • HY-RS25107
    Lipe Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Lipe Rat Pre-designed siRNA Set A contains three designed siRNAs for Lipe gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lipe Rat Pre-designed siRNA Set A
    Lipe Rat Pre-designed siRNA Set A
  • HY-10224AR
    Panobinostat lactate (Standard)

    LBH589 lactate (Standard); NVP-LBH589 lactate (Standard)

    		 Reference Standards HDAC HIV Autophagy Apoptosis Infection Cancer
    Panobinostat lactate (Standard) is the analytical standard of Panobinostat lactate (HY-10224A). This product is intended for research and analytical applications. Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma .
    Panobinostat lactate (Standard)
  • HY-P992386
    IMM47

    		CD22 Cancer
    IMM47 is a humanized monoclonal antibody targeting CD24, which acts as a competitive inhibitor of the CD24/Siglec-10 interaction and exhibits potent anti-tumor activity. The EC50 value of IMM47 for CD24 is 0.289 nM, and its Ka is 0.876 nM. IMM47 selectively binds to CD24-positive tumor cells and human granulocytes. By competitively blocking CD24/Siglec-10 binding, IMM47 abrogates the immunosuppressive signals of tumor cells, clears tumor cells through multiple effector pathways including ADCC, ADCP, ADCT and CDC, upregulates the levels of M1 and M2 macrophages in the spleen, promotes macrophage antigen presentation and induces tumor-specific memory immunity. IMM47 can be used in cancer-related research .
    IMM47

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