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Results for "

Ryanodine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Calcium Channel (12) Endogenous Metabolite (5) Glutathione Reductase (1) Isotope-Labeled Compounds (1) Parasite (5) Sodium Channel (2) TRP Channel (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (5) Endocrinology (2) Infection (4) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113920A

Azumolene EU4093 free base	Calcium Channel	Metabolic Disease
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research .

HY-103306

*Ryanodine*	Others	Neurological Disease
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca ²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-155394

RyRs activator 5

Others Metabolic Disease

RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .

RyRs activator 5	Others	Metabolic Disease
RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .

HY-146109

RyRs activator 1	Parasite	Infection
RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .

HY-155334

RyRs activator 4	Others	Others
RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC₅₀ value of 1.32 mg/L .

HY-110312

JTV-519 fumarate K201 fumarate	Others	Cardiovascular Disease
JTV-519 fumarate (K201 fumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects .

HY-146110

RyRs activator 2	Parasite	Infection
RyRs activator 2 (compound 7o) is a potent activator of ryanodine receptors (RyRs). RyRs activator 2 is 30% larvicidal activity, comparable to chlorantraniliprole (30%) and better than cyantraniliprole (10%) .

HY-163157

Insecticidal agent 7	Parasite	Others
Insecticidal agent 7 (Compound 21m) is an insecticide that targets the insect ryanodine receptors (RyRs) with a LC₅₀ of 0.0937 mg/L for the Plutella xylostella. Insecticidal agent 7 (Compound 21m) exhibits good selectivity and low toxicity towards non-target organisms .

HY-156082

RyRs activator 3	Parasite Calcium Channel	Others
RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity .

HY-N7491A

Ent-(+)-Verticilide	Calcium Channel	Cancer
ent-(+)-verticilide is a potent and selective inhibitor of *cardiac ryanodine* receptor (RyR2) calcium release channels** with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca ²⁺?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .

HY-N7395

Cyclic ADP-ribose cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N7491

Verticilide	Calcium Channel	Inflammation/Immunology
Verticilide is a *ryanodine-binding* inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

HY-N7395A

Cyclic ADP-ribose ammonium cADPR ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-12542

Dantrolene Maximum Cited Publications 7 Publications Verification F 368	Calcium Channel Autophagy	Neurological Disease Inflammation/Immunology
Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-12542A

Dantrolene sodium hemiheptahydrate Maximum Cited Publications 7 Publications Verification Dantrolene sodium hydrate	Calcium Channel Autophagy	Others
Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-112820

Chlorantraniliprole 1 Publications Verification	Others	Others
Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC₅₀s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM).

HY-W016498

Paraxanthine 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-W016498S

Paraxanthine-d6	Endogenous Metabolite	Neurological Disease
Paraxanthine-d₆ is the deuterium labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-P3037

Imperatoxin A	Calcium Channel
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-138806

PAQ	Others	Neurological Disease
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells .

HY-15293

JTV-519 K201	Calcium Channel	Cardiovascular Disease
JTV-519 (K201) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-W016498S1

Paraxanthine-13C4,15N3	Endogenous Metabolite	Neurological Disease
Paraxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-15293B

JTV-519 hemifumarate K201 hemifumarate	Calcium Channel	Cardiovascular Disease
JTV-519 hemifumarate (K201 hemifumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-15293A

JTV-519 free base K201 free base
JTV-519 free base (K201 free base) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-149697

Insecticidal agent 6	Parasite	Others
Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC₅₀ value of 0.6308 µM against S. frugiperda RyRs. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases .

HY-12542S

Dantrolene-13C3 F 368-¹³C₃	Isotope-Labeled Compounds Glutathione Reductase	Neurological Disease Inflammation/Immunology
Dantrolene- ¹³C₃ is the ¹³C₃ labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ⁺Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ⁺Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

Cat. No.	Product Name	Target	Research Area

HY-N7491

Verticilide	Calcium Channel	Inflammation/Immunology
Verticilide is a *ryanodine-binding* inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-P5319

MCaE12A	Peptides	Others
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-P3037

Imperatoxin A	Calcium Channel
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ⁺Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ⁺Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7395A

Cyclic ADP-ribose ammonium cADPR ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-W016498

Paraxanthine 1 Publications Verification	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-103306

*Ryanodine*	Structural Classification other families Neurological Disease Classification of Application Fields Terpenoids Source classification Ryania speciosa Diterpenoids Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Others
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca ²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-N7395

Cyclic ADP-ribose cADPR	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N7491

Verticilide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Calcium Channel
Verticilide is a *ryanodine-binding* inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

Cat. No.	Product Name	Chemical Structure

HY-W016498S

Paraxanthine-d6
Paraxanthine-d₆ is the deuterium labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-W016498S1

Paraxanthine-13C4,15N3
Paraxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.

HY-12542S

Dantrolene-13C3

Dantrolene- ¹³C₃ is the ¹³C₃ labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.

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Ryanodine

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products