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Isoforms Recommended:	p70S6K

Results for "

S6K1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (2) Casein Kinase (2) CDK (2) IKK (1) mTOR (1) PDK-1 (3) PI3K (1) PKC (2) Reactive Oxygen Species (1) Ribosomal S6 Kinase (RSK) (10) SGK (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (2)

16

Inhibitors & Agonists

1

Peptides

2

Natural
Products

1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152944

S6K1-IN-DG2

Ribosomal S6 Kinase (RSK) Cancer

S6K1-IN-DG2 (Compound 66) is a p70S6K inhibitor (IC₅₀: < 100 nM) .
HY-18313

S6K1-IN-1

Ribosomal S6 Kinase (RSK) Metabolic Disease

S6K-18 is a potent and selective p70S6K1 inhibitor with an IC₅₀ of 52 nM .

Eudesmin (-)-Eudesmin; Eudesmine; (-)-Eudesmine	Ribosomal S6 Kinase (RSK)	Infection Metabolic Disease Inflammation/Immunology Cancer
Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of *S6K1* signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities .

HY-15773

PF-4708671

15+ Cited Publications

Ribosomal S6 Kinase (RSK) Autophagy Cancer

PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K_i of 20 nM and IC₅₀ of 160 nM.

Coronarin A	mTOR Ribosomal S6 Kinase (RSK)	Metabolic Disease Inflammation/Immunology
Coronarin A is an orally active natural compound that inhibits mTORC1 and *S6K1* to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research .

PDK1-IN-RS2	PDK-1	Cancer
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a K_d of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1 .

LY-2584702 tosylate salt 5 Publications Verification	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 tosylate salt is a selective ATP competitive inhibitor of p70S6K with an IC₅₀ of 4 nM. In *S6K1* enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

LY-2584702 hydrochloride	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 hydrochloride is a selective ATP competitive inhibitor of p70S6K with an IC₅₀ of 4 nM. In *S6K1* enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

LY-2584702 free base	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 free base is a selective ATP competitive inhibitor of p70S6K with an IC₅₀ of 4 nM. In *S6K1* enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

CKI-7	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .

CKI-7 free base	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .

BX795 Maximum Cited Publications 22 Publications Verification	PDK-1 IKK Autophagy	Cancer
BX795 is a potent and selective inhibitor of PDK1, with an IC₅₀ of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC₅₀ of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy .

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the *PI3K-AKT-S6K1* pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Ro 31-8220 mesylate 10+ Cited Publications Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate	PKC	Cardiovascular Disease Neurological Disease Cancer
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Ro 31-8220 Bisindolylmaleimide IX	PKC	Cardiovascular Disease Neurological Disease
Ro 31-8220 is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

PS210	PDK-1	Cancer
PS210 is a potent and selective PDK1 activator with a K_d of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K .

Cat. No.	Product Name	Target	Research Area

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the *PI3K-AKT-S6K1* pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Compare	Product Name	Species	Source

	S6K1/RPS6KB1 Protein, Human (sf9, GST) Ribosomal protein S6 kinase beta-1; S6K1; P70S6K1; p70 S6KA; RPS6KB1; STK14A	Human	Sf9 insect cells
	S6K1/RPS6KB1 is a kinase downstream of mTOR that regulates cellular processes critical for proliferation, growth, and cell cycle. It phosphorylates EIF4B, RPS6 and EEF2K and regulates protein synthesis by inhibiting the pro-apoptotic function of BAD, thereby enhancing cell survival. S6K1/RPS6KB1 Protein, Human (sf9, GST) is the recombinant human-derived S6K1/RPS6KB1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of S6K1/RPS6KB1 Protein, Human (sf9, GST) is 525 a.a., with molecular weight of ~96 kDa.

Cat. No.	Product Name	Application	Reactivity

RPS6KB1 Antibody p70(S6K)-alpha; ribosomal protein S6 kinase; p70 S6 Kinase; P70 Beta1; KS6B1_HUMAN; Ribosomal protein S6 kinase beta-1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha.	WB; ELISA; IHC-P; IHC-F; IF	Human, Rat(predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Goat)
RPS6KB1 Antibody is an unconjugated, approximately 70 kDa, rabbit-derived, anti-RPS6KB1 polyclonal antibody. RPS6KB1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, rat, and predicted: mouse, chicken, dog, pig, cow, horse, rabbit, goat background without labeling.

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