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SAG

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Fungal (1) HBV (1) Hedgehog (1) Small Interfering RNA (siRNA) (1) Smo (6)
By Research Areas:	Cancer (5) Infection (4) Metabolic Disease (2)

11

Inhibitors & Agonists

3

Peptides

1

Natural
Products

3

Recombinant Proteins

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*SAG* Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848S

SAG-d3

Smo Cancer

SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

SAG hydrochloride Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

SAG dihydrochloride Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

SAG-524	HBV	Infection
SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC₅₀ 0.92 and 1.4 nM, respectively .

SAG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SAG Human Pre-designed siRNA Set A contains three designed siRNAs for SAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SAG Human Pre-designed siRNA Set A SAG Human Pre-designed siRNA Set A

Hh-Ag1.5 1 Publications Verification SAG1.5	Hedgehog	Metabolic Disease
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC₅₀ of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

DO34 2 Publications Verification	Others	Metabolic Disease
DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC₅₀ for DAGLβ.

HY-110240

IHR-1

Smo Others

IHR-1 is a cell membrane impermeable Smo antagonist .

Dehydrotomatine	Bacterial Fungal	Infection
Dehydrotomatine is a steroidal glycoalkaloid (SGA). α-tomatine and Dehydrotomatine accumulate in the mature green fruits, leaves, and flowers of tomatoes (Solanum lycopersicum) and function as defensive compounds against pathogens and predators. SGAs show toxic effects on fungi, bacteria, insects, and animals .

Species:	Human (2)
Tag:	His (3)
Source:	HEK293 (1) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	DMBT1 Protein, Human (HEK293, His) Deleted in malignant brain tumors 1 protein; Glycoprotein 340; Gp-340; Hensin; SAG; DMBT1	Human	HEK293
	The DMBT1 protein is a potential tumor suppressor in a variety of cancers and affects a variety of biological processes. It contributes to mucosal and cellular immune defense, epithelial differentiation, and serves as an opsonin receptor for SFTPD and SPAR in macrophages. DMBT1 Protein, Human (HEK293, His) is the recombinant human-derived DMBT1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DMBT1 Protein, Human (HEK293, His) is 201 a.a., with molecular weight of 35-45 kDa.

	SAG Protein, Human (P.pastoris, His) 48kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; S antigen; S arrestin; S-AG; S-arrestin; SAG	Human	P. pastoris
	SAG proteins play a crucial role in phototransduction, regulating signal transduction by binding to light-activated and phosphorylated rhodopsin (RHO). It terminates RHO signaling by competitively interacting with G proteins at the same binding site on RHO. SAG Protein, Human (P.pastoris, His) is the recombinant human-derived SAG protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of SAG Protein, Human (P.pastoris, His) is 405 a.a., with molecular weight of ~47.1 kDa.

HY-P79168

Hyaluronan Lyase Protein, S. agActiae (His)

Hyaluronidase; SAG1197
Others E. coli

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