SCA

By Targets:	5-HT Receptor (1) Potassium Channel (2)
By Research Areas:	Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111200

Vabicaserin hydrochloride 2 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) receptor-selective agonist with an EC₅₀ of 8 nM.

HY-109160

Rimtuzalcap CAD-1883	Potassium Channel	Neurological Disease
Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .

HY-102070

NS13001	Potassium Channel	Neurological Disease
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC₅₀s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias .

Cat. No.	Product Name

HY-L086

Neurodegenerative Disease-related Compound Library	2221 compounds
Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour. MCE offers a unique collection of 2221 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

Neurodegenerative Disease-related Compound Library

2221 compounds

Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.

MCE offers a unique collection of 2221 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

Species:	Human (6) Mouse (2)
Tag:	His (6) SUMO (2) Tag Free (1) Strep (1) GST (1)
Source:	HEK293 (1) Sf9 insect cells (1) P. pastoris (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71058

	PDYN Protein, Human (HEK293, His) ADCA; PENKB; SCA23; PDYN; Dynorphin B; Big Dyn	Human	HEK293
	The PDYN protein, or prodynorphin, regulates Leu-enkephalins, mimicking opiate drug effects and impacting pain perception and stress responses. Dynorphin peptides, like Dynorphin A(1-13), uniquely regulate the kappa opioid receptor, with A(1-13) being exceptionally potent—700 times stronger than Leu-enkephalin—displaying typical opioid activity. PDYN Protein, Human (HEK293, His) is the recombinant human-derived PDYN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDYN Protein, Human (HEK293, His) is 234 a.a., with molecular weight of ~35.0 kDa.

HY-P71539

	Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) LY6E; 9804; RIGE; SCA2; TSA1; Lymphocyte antigen 6E; Ly-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1	Human	E. coli
	Lymphocyte antigen 6E/LY6E protein is a GPI-anchored cell surface regulator that regulates T cell receptor signaling through interaction with CD3Z/CD247. It limits the entry of human coronaviruses, serves as the primary receptor for syncytin-A, and may modulate nicotinic acetylcholine receptor activity. Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) is the recombinant human-derived Lymphocyte antigen 6E/LY6E protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) is 81 a.a., with molecular weight of ~24.5 kDa.

HY-P702640

PRKCG Protein, Human (sf9, GST)

PRKCG; protein kinase C, gamma; PKCG, SCA14; protein kinase C gamma type; MGC57564; PKC gamma; PKCC; PKCG; SCA14; PKC-gamma
Human Sf9 insect cells

HY-P701341

	Caspase-3/CASP3 Protein, Human CASP3; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	Human	E. coli
	Caspase-3/CASP3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. Caspase-3/CASP3 Protein, Human is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with tag free. The total length of Caspase-3/CASP3 Protein, Human is 248 a.a., .

HY-P79456

	Ataxin-3 Protein, Human (His) Ataxin-3; ATXN3; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein; ATX3, MJD, MJD1; SCA3	Human	E. coli
	Ataxin-3 is a deubiquitinating enzyme that maintains proteostasis, regulates transcription, and is involved in cytoskeletal dynamics, myogenesis, and degradation of misfolded chaperone substrates. It trims long polyubiquitin chains and interacts with STUB1/CHIP to limit ubiquitin chain length, preventing further elongation. Ataxin-3 Protein, Human (His) is the recombinant human-derived Ataxin-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Ataxin-3 Protein, Human (His) is 361 a.a., with molecular weight of ~43 kDa.

HY-P701342

	Caspase-3/CASP3 Protein, Human (His, Strep) CASP3; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	Human	E. coli
	Caspase-3/CASP3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. Caspase-3/CASP3 Protein, Human (His, Strep) is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of Caspase-3/CASP3 Protein, Human (His, Strep) is 277 a.a., .

HY-P75920

	Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His) Lymphocyte antigen 6A-2/6E-1; Ly-6A.2/Ly-6E.1; SCA-1; TAP; Ly6	Mouse	E. coli
	Lymphocyte antigen 6A-2/LY6A Protein, crucial for T-cell activation, plays a key role in immune responses. Its ability to facilitate T-cell activation underscores its importance in regulating T-cell responses and immune surveillance. The molecular interactions and signaling pathways in which LY6A participates during T-cell activation highlight its significance as a key orchestrator in immune responses, contributing to immune homeostasis. Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His) is the recombinant mouse-derived Lymphocyte antigen 6A-2/LY6A protein, expressed by E. coli , with N-His labeled tag. The total length of Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His) is 93 a.a., with molecular weight of ~10.9 kDa.

HY-P71830

	Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO) Ly6e; Ly67; SCA-2; Tsa-1Lymphocyte antigen 6E; Ly-6E; Stem cell antigen 2; Thymic shared antigen 1; TSA-1	Mouse	P. pastoris
	LY6E is a GPI-anchored cell surface protein that regulates T lymphocyte function by binding to CD3Z/CD247, affecting proliferation, differentiation and activation. It modulates T cell receptor signaling and exhibits antiviral activity against mouse hepatitis virus. Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO) is the recombinant mouse-derived Lymphocyte antigen 6E/LY6E protein, expressed by P. pastoris , with N-His, N-SUMO labeled tag. The total length of Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO) is 82 a.a., with molecular weight of ~24.8 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81851

IP3 Receptor Antibody (YA1596)

5-trisphosphate receptor; Inositol 1; InsP3R1; IP3; IP3 receptor; IP3R 1; IP3R; IP3R1; Itpr1; SCA15; SCA16; SCA29
WB Human, Mouse, Rat
HY-P82432

Ataxin 1 Antibody (YA2177)

ATX1; SCA1; D6S504E
WB, IP Mouse

HY-P80623

Cleaved-Caspase 3 p12 Antibody CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, ICC/IF	Human, Mouse, Rat
Cleaved-Caspase 3 p12 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to Cleaved-Caspase 3 p12. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82773

Ly6A/E Antibody (YA2518) Ly-6A.2/Ly-6E.1; Ly6a; Ly6al; Lymphocyte antigen 6A-2/6E-1; Lymphocyte antigen Ly 6A.2/Ly 6E.1; SCA-1; Stem cell antigen 1; T cell activating protein; TAP	WB, IHC-P	Mouse

HY-P81549

Ataxin 3 Antibody (YA1294)

ATX3, MJD, MJD1, SCA3, ATXN3
IHC-P Human, Mouse, Rat

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