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Results for "

SF-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) MicroRNA (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (7) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: SF3B1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107404

SID 7969543	Others	Endocrinology
SID 7969543 is a selective *SF-1* (steroidogenic factor 1, NR5A1) inhibitor with an IC₅₀ of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC₅₀ of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily ^[1] .

HY-131445B

RR-RJW100	Others	Metabolic Disease
RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease ^[1] .

HY-148259

SF-1 antagonist-1	Others	Cancer
SF-1 antagonist-1 (compound 11) is a antagonist of steroidogenic factor 1 (SF-1). SF-1 antagonist-1 affects SF-1 transcriptional activity with an EC₅₀ value of ＜200 nM. SF-1 antagonist-1 inhibits the proliferation of Rat Leydig tumor cells. SF-1 antagonist-1 can be used for the research of cancer ^[1].

HY-RS12756

SF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF1 Human Pre-designed siRNA Set A SF1 Human Pre-designed siRNA Set A

HY-131445

RJW100	MicroRNA	Endocrinology Cancer
RJW100 is a potent *liver receptor homolog 1 (LRH-1, NR5A2)* and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC₅₀s of 6.6 and 7.5, respectively ^[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .

HY-115613

ML-180 SR1848	Others	Cancer
ML-180 (SR1848) is a potent orphan nuclear receptor *liver receptor homolog 1 (LRH-1; NR5A2)* inverse agonist with an IC₅₀ of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC₅₀>10 µM). ML-180 has the potential for LRH-1-dependent cancers ^[1] .

HY-131445A

SS-RJW100	Others	Metabolic Disease Inflammation/Immunology
SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability ^[1] .

HY-128207

SID7970631	Others	Cancer
SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar *SF-1* inhibitor (IC₅₀=255 nM). SID7970631 can be used for the research of cancer ^[1] .

HY-RS14606

TM4SF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TM4SF1 Human Pre-designed siRNA Set A TM4SF1 Human Pre-designed siRNA Set A

HY-153736

NSC 194308	Others	Cancer
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations ^[1].

HY-129372

PDdB-Pfp	ADC Linker	Cancer
PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) ^[1].

HY-129359

PDP-Pfp

ADC Linker Cancer

PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) ^[1].

PDP-Pfp	ADC Linker	Cancer
PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of *TM4SF1* (transmembrane 4 L6 family member 1) ^[1].

Species:	Human (2) Cynomolgus (1)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (2) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700837

TM4SF1 Protein-VLP, Human (HEK293)

M3S1; TAAL6; H-L6; L6
Human HEK293

TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.

	TM4SF1 Protein-VLP, Human (HEK293) M3S1; TAAL6; H-L6; L6	Human	HEK293
	TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.

HY-P702595

	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) M3S1; TAAL6; H-L6; L6	Cynomolgus	HEK293
	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P701329

	TM4SF1 Protein,Human (N-His) M3S1; Membrane component chromosome 3 surface marker 1; T4S1_HUMAN; TAAL6; Tm4SF1; Transmembrane 4 L6 family member 1; Tumor-associated antigen L6	Human	P. pastoris
	TM4SF1 protein-VLP is present in tumor cells and can form high molecular weight complexes, indicating its involvement in complex cellular processes in malignant tumors. It interacts with SDCBP2, emphasizing its association with specific molecular pathways, suggesting a role in cell signaling or regulatory mechanisms. TM4SF1 Protein,Human (N-His) is the recombinant human-derived TM4SF1 protein,Human, expressed by P. pastoris , with N-His labeled tag. The total length of TM4SF1 Protein,Human (N-His) is 47 a.a., with molecular weight of 7.3 kDa.


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