Search Result

Results for "

SH2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Autophagy (2) Bcl-2 Family (1) ERK (1) Ligands for Target Protein for PROTAC (1) Phosphatase (2) PI3K (2) PROTACs (1) SHP2 (1) Small Interfering RNA (siRNA) (8) Src (5) STAT (21) Syk (1) Tyrosinase (1)
By Research Areas:	Cancer (29) Inflammation/Immunology (7) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS12818

SH2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2B1 Human Pre-designed siRNA Set A SH2B1 Human Pre-designed siRNA Set A

HY-RS12819

SH2B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2B2 Human Pre-designed siRNA Set A SH2B2 Human Pre-designed siRNA Set A

HY-RS12820

SH2B3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2B3 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2B3 Human Pre-designed siRNA Set A SH2B3 Human Pre-designed siRNA Set A

HY-RS12821

SH2D1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D1A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D1A Human Pre-designed siRNA Set A SH2D1A Human Pre-designed siRNA Set A

HY-RS12823

SH2D2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D2A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D2A Human Pre-designed siRNA Set A SH2D2A Human Pre-designed siRNA Set A

HY-RS12825

SH2D4A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D4A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D4A Human Pre-designed siRNA Set A SH2D4A Human Pre-designed siRNA Set A

HY-RS12822

SH2D1B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D1B Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D1B Human Pre-designed siRNA Set A SH2D1B Human Pre-designed siRNA Set A

HY-RS12824

SH2D3C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D3C Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D3C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D3C Human Pre-designed siRNA Set A SH2D3C Human Pre-designed siRNA Set A

HY-151577

*STAT3-SH2* domain inhibitor 1**	STAT Apoptosis	Cancer
STAT3-SH2 domain inhibitor 1 is a potent *Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2* domain) inhibitor with a K_d** value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer .

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains ^[2].

HY-153992

STAT6-IN-3	STAT	Inflammation/Immunology
STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC₅₀= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma .

HY-151634

Syk-IN-6	Syk STAT ERK	Cancer
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML) .

HY-129800

CGP78850

Others Cancer

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer .
HY-18685

CPDA

Phosphatase Metabolic Disease

CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

CGP78850	Others	Cancer
CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer .

CPDA	Phosphatase	Metabolic Disease
CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

HY-121725

MM-206	STAT	Cancer
MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC₅₀ of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines .

HY-162355

SHP2-IN-27

SHP2 Cancer

SHP2-IN-27 (compound 28) is an allosteric inhibitor of tyrosine phosphatase SH2 .

SHP2-IN-27	SHP2	Cancer
SHP2-IN-27 (compound 28) is an allosteric inhibitor of tyrosine phosphatase *SH2* .

HY-P0175A

740 Y-P TFA 740YPDGFR TFA; PDGFR 740Y-P TFA	PI3K Autophagy	Cancer
740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

HY-13818

Stattic Maximum Cited Publications 137 Publications Verification	STAT Apoptosis	Inflammation/Immunology Cancer
Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) . Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 ^[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .

HY-112647

Stafib-1

STAT Cancer

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a K_i of 44 nM and an IC₅₀ of 154 nM .

Stafib-1	STAT	Cancer
Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a K_i of 44 nM and an IC₅₀ of 154 nM .

HY-P1200

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P1377

Caffeic acid-pYEEIE

Src Inflammation/Immunology

Caffeic acid-pYEEIE, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .
HY-P1377A

Caffeic acid-pYEEIE TFA

Src Inflammation/Immunology

Caffeic acid-pYEEIE TFA, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .

Caffeic acid-pYEEIE	Src	Inflammation/Immunology
Caffeic acid-pYEEIE, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .

Caffeic acid-pYEEIE TFA	Src	Inflammation/Immunology
Caffeic acid-pYEEIE TFA, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .

HY-P1200A

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P0175

740 Y-P 125+ Cited Publications 740YPDGFR; PDGFR 740Y-P	PI3K Autophagy	Cancer
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

HY-W035137

5,15-Diphenylporphyrin

5,15-DPP
STAT Cancer

5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist (IC₅₀s of 0.28 µM and 10 µM for STAT3 and STAT1, respectively) .

5,15-Diphenylporphyrin 5,15-DPP	STAT	Cancer
5,15-Diphenylporphyrin (5,15-DPP) is a selective *STAT3-SH2* antagonist (IC₅₀s of 0.28 µM and 10 µM for STAT3 and STAT1, respectively) .

HY-19776

3α-Aminocholestane 4 Publications Verification	Phosphatase	Cancer
3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC₅₀ of ~2.5 μM.

HY-146728

STAT3-IN-10

STAT Apoptosis Cancer

STAT3-IN-10 is a STAT3 inhibitor with an IC₅₀ value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis .

STAT3-IN-10	STAT Apoptosis	Cancer
STAT3-IN-10 is a STAT3 inhibitor with an IC₅₀ value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis .

HY-150603

STAT3-IN-13	STAT Apoptosis Bcl-2 Family	Cancer
STAT3-IN-13 (compound 6f) is a potent STAT3 inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a K_D of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces apoptosis in vitro and suppresses the growth and metastasis of tumor in vivo. STAT3-IN-13 can be used for cancer research .

HY-136179

ZAP-180013 1 Publications Verification	Tyrosinase	Inflammation/Immunology
ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC₅₀ of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs) .

HY-148093

PM-81I	STAT	Inflammation/Immunology Cancer
PM-81I is a potent STAT6 inhibitor (targeting the *SH2* structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer ^[1].

HY-148096

STAT6-IN-1	STAT	Inflammation/Immunology Cancer
STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the *SH2* domain of STAT6 (IC₅₀=0.028 µM). STAT6-IN-1 can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer ^[2].

HY-124500

AC-4-130 3 Publications Verification	STAT Apoptosis	Cancer
AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .

HY-129603

SI-109	STAT Ligands for Target Protein for PROTAC	Cancer
SI-109 is a potent *STAT3 SH2* domain inhibitor (K_i=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC₅₀=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36** .

HY-112338

C188 CPD188	STAT	Cancer
C188 is a STAT3 inhibitor that inhibits IL-6-stimulated STAT3 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducing apoptosis of the breast cancer cell line MB-MDA-468 in vitro (EC₅₀= 0.7 μM).

HY-155982

STAT3-IN-20	STAT	Cancer
STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC₅₀: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC₅₀: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis .

HY-P10201

Ac-GpYLPQTV-NH2

STAT Cancer

Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .

Ac-GpYLPQTV-NH2	STAT	Cancer
Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .

HY-136546

Stafia-1 1 Publications Verification	STAT	Cancer
Stafia-1 is a potent STAT5a inhibitor (K_i=10.9 μM, *IC₅₀*=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members .

HY-P10202

5-FAM-GpYLPQTV-NH2

STAT Cancer

5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 can be used in cancer research .

5-FAM-GpYLPQTV-NH2	STAT	Cancer
5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 can be used in cancer research .

HY-P10202A

5-FAM-GpYLPQTV-NH2 TFA	STAT	Cancer
5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 (TFA) can be used in cancer research .

HY-115594

Erasin	STAT Apoptosis	Cancer
Erasin is a potent Erlotinib (HY-50896)-resistance antagonizing STAT3 inhibitor with IC₅₀s of 9.7 and 24 μM against STAT3 and STAT1, respectively. Erasin induces cancer cells apoptosis .

HY-129602

SD-36 5 Publications Verification	PROTACs STAT Apoptosis	Cancer
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-146127A

*Grb2 SH2* domain inhibitor 1 TFA**	Peptides	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains ^[2].

HY-146127

*Grb2 SH2* domain inhibitor 1**	Peptides	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P3787

Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2	Peptides	Metabolic Disease
Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 is the SH2 domain ligand. SH2 domains participate in protein tyrosine kinase (PTK)-mediated cellular signal .

HY-P0175A

740 Y-P TFA 740YPDGFR TFA; PDGFR 740Y-P TFA	PI3K Autophagy	Cancer
740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

HY-P1200

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P1377

Caffeic acid-pYEEIE

Src Inflammation/Immunology

Caffeic acid-pYEEIE, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .
HY-P1377A

Caffeic acid-pYEEIE TFA

Src Inflammation/Immunology

Caffeic acid-pYEEIE TFA, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .

HY-P1200A

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P0175

740 Y-P Maximum Cited Publications 126 Publications Verification 740YPDGFR; PDGFR 740Y-P	PI3K Autophagy	Cancer
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .

HY-P5433

IRS1-derived peptide	Peptides	Others
IRS1-derived peptide is a biological active peptide. (This is a peptide fragment (979-989) of the insulin receptor substrate-1 containing the sequence motif YMXM known to bind to the two domains of SH2 on the 85kDa subunit of phosphoinositide 3-kinase.)

HY-P10224

G7-18NATE	Peptides	Cancer
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines ^[2].

HY-P10201

Ac-GpYLPQTV-NH2

STAT Cancer

Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .
HY-P10202

5-FAM-GpYLPQTV-NH2

STAT Cancer

5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 can be used in cancer research .

HY-P10202A

5-FAM-GpYLPQTV-NH2 TFA	STAT	Cancer
5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 (TFA) can be used in cancer research .

Species:	Human (5)
Tag:	His (5) T7 (1)
Source:	P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71038

	SH2D1A Protein, Human (His) SH2 Domain-Containing Protein 1A; Duncan Disease SH2-Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; SLAM-Associated Protein; T-Cell Signal Transduction Molecule SAP; SH2D1A; DSHP; SAP	Human	E. coli
	SH2D1A protein regulates receptors of the SLAM family (SLAMF1, CD244, LY9, CD84, SLAMF6, and SLAMF7). SH2D1A Protein, Human (His) is the recombinant human-derived SH2D1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of SH2D1A Protein, Human (His) is 128 a.a., with molecular weight of ~16.0 kDa.

HY-P71320

	SLP-76 Protein, Human (His-T7) Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2	Human	E. coli
	The SLP-76 protein is critical in T cell antigen receptor-mediated signaling and participates in multiple molecular interactions. Its association with SLA coordinates T cell signaling, whereas its interaction with CBLB emphasizes regulatory effects. SLP-76 Protein, Human (His-T7) is the recombinant human-derived SLP-76 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of SLP-76 Protein, Human (His-T7) is 533 a.a., with molecular weight of ~70.0 kDa.

HY-P70304

	NCK1 Protein, Human (His) rHuCytoplasmic protein NCK1/NCK1, His; Cytoplasmic Protein NCK1; NCK adaptor Protein 1; Nck-1; SH2/SH3 Adaptor Protein NCK-Alpha; NCK1; NCK	Human	E. coli
	NCK1 protein is an adapter protein that binds to tyrosine phosphorylated receptors (KDR, PDGFRB) and cellular substrates and plays a key role in the dephosphorylation of EIF2S1 by PP1. It contributes to the efficient activation of DNA damage response effector (CHEK2) and ELK1-dependent transcriptional activation in Ras signaling. NCK1 Protein, Human (His) is the recombinant human-derived NCK1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NCK1 Protein, Human (His) is 377 a.a., with molecular weight of ~50.0 kDa.

HY-P70396

	Grb2 Protein, Human (His) rHuGrowth factor receptor-bound protein 2/GRB2, His; Growth Factor Receptor-Bound Protein 2; Adapter Protein GRB2; Protein ASH; SH2/SH3 Adapter GRB2; GRB2; ASH	Human	E. coli
	Grb2, an adapter protein, crucially connects cell surface growth factor receptors to the Ras signaling pathway. Despite no direct binding to phosphorylated EGFR, Grb2 inhibits EGF-induced transactivation of a RAS-responsive element. It acts as a dominant negative relative to GRB2, suppressing proliferative signals and potentially initiating programmed cell death. Grb2 Protein, Human (His) is the recombinant human-derived Grb2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Grb2 Protein, Human (His) is 217 a.a., with molecular weight of 25-29 kDa.

HY-P71785

	SOCS1 Protein, Human (P.pastoris, His) CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3	Human	P. pastoris
	The SOCS1 protein is an important negative regulator that inhibits type I and type II interferon signaling as well as cytokines such as IL2, IL4, IL6, and LIF. It downregulates the signaling of the JAK/STAT pathway by inhibiting JAK proteins and IFNGR1. SOCS1 Protein, Human (P.pastoris, His) is the recombinant human-derived SOCS1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of SOCS1 Protein, Human (P.pastoris, His) is 211 a.a., with molecular weight of ~25.6 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P83087

SHIP1 Antibody (YA2832) INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, IHC-P, IP, FC	Human

HY-P83344

Phospho-SHIP1 (Tyr1020) Antibody (YA3089) INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, ICC/IF, IP	Human

HY-P82649

SHC Antibody (YA2394) SHC1; SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82205

SH2D1A Antibody (YA1950)

LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A
WB Human, Mouse, Rat

HY-P80695

GRB2 Antibody (YA748) GRB2; ASH; Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein ASH; SH2/SH3 adapter GRB2	WB	Human, Mouse, Rat
GRB2 Antibody (YA748) is a non-conjugated and Mouse origined monoclonal antibody about 25 kDa, targeting to GRB2 (5G3). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P83548

NCK2 Antibody (YA3293) NCK2; GRB4; Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta	WB, ICC/IF	Human, Mouse, Rat

HY-P82537

BLNK Antibody (YA2282) BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa	WB, IP	Human, Mouse, Rat

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