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SHP-099

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100388
    SHP099
    Maximum Cited Publications
    53 Publications Verification

    		 SHP2 Phosphatase Cancer
    SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM .
    <em>SHP099</em>
  • HY-100388A
    SHP099 monohydrochloride
    Maximum Cited Publications
    53 Publications Verification

    		 SHP2 Phosphatase Cancer
    SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM .
    <em>SHP099</em> monohydrochloride
  • HY-100388B
    SHP099 hydrochloride

    		SHP2 Cancer
    SHP099 hydrochloride is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2 D61Y, SHP2E69K, SHP2 A72V, SHP2 E76K. SHP099 hydrochloride inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 hydrochloride inhibits RAS-ERK signaling and inhibit tumor growth .
    <em>SHP099</em> hydrochloride

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