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SIK1 Inhibitors

" in MCE Product Catalog:

By Targets:	AMPK (1) Apoptosis (2) PAK (1) Salt-inducible Kinase (SIK) (7)
By Research Areas:	Cancer (3) Inflammation/Immunology (5)

Cat. No.	Product Name	Target	Research Areas

MRIA9	Salt-inducible Kinase (SIK) PAK Apoptosis	Cancer
MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC₅₀ values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.

HG-9-91-01 SIK inhibitor 1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC₅₀s of 0.92 nM, 6.6 nM and 9.6 nM for *SIK1, SIK2* and SIK3 respectively.

YKL-06-062	Salt-inducible Kinase (SIK)	Inflammation/Immunology
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC₅₀ of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.

YKL-06-061	Salt-inducible Kinase (SIK)	Inflammation/Immunology
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC₅₀ values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.

ARN-3236	Salt-inducible Kinase (SIK)	Cancer Inflammation/Immunology
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC₅₀s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity.

YKL-05-099	Salt-inducible Kinase (SIK)	Inflammation/Immunology
YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to *SIK1* and SIK3 with IC₅₀s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC₅₀=40 nM).

MRT199665	Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and *SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis* in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370.

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