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Results for "SIX1 Inhibitors" in MCE Product Catalog:

Cat. No. Product Name Target Research Areas
  • HY-138657
    NCGC00378430

    Phosphatase Cancer
    NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor with an IC50 of 52 μM in the Alphascreen assay. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and EMT. NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model.