Search Result

Results for "

SK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (2) Adrenergic Receptor (2) Androgen Receptor (1) Antibiotic (2) Apoptosis (10) Bacterial (1) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (1) Dopamine Receptor (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (2) Endothelin Receptor (1) ERK (1) Fluorescent Dye (1) GABA Receptor (1) Glucocorticoid Receptor (2) Histamine Receptor (1) Histone Acetyltransferase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) LPL Receptor (2) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) PAI-1 (1) PAK (2) Parasite (1) PARP (2) PGE synthase (1) Phosphodiesterase (PDE) (2) Potassium Channel (15) PROTACs (2) Raf (1) Sigma Receptor (1) SphK (6) Tyrosinase (1) Vasopressin Receptor (1) Wnt (3) β-catenin (2)
By Research Areas:	Cancer (46) Cardiovascular Disease (9) Endocrinology (5) Infection (2) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (15)

By Targets:

ADC Cytotoxin (2)

Adrenergic Receptor (2)

Androgen Receptor (1)

Antibiotic (2)

Apoptosis (10)

Bacterial (1)

Dipeptidyl Peptidase (2)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (2)

Endothelin Receptor (1)

ERK (1)

Fluorescent Dye (1)

GABA Receptor (1)

Glucocorticoid Receptor (2)

Histamine Receptor (1)

Histone Acetyltransferase (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

LPL Receptor (2)

Microtubule/Tubulin (3)

Mitochondrial Metabolism (1)

PAI-1 (1)

PAK (2)

Parasite (1)

PARP (2)

PGE synthase (1)

Phosphodiesterase (PDE) (2)

Potassium Channel (15)

PROTACs (2)

Raf (1)

Sigma Receptor (1)

SphK (6)

Tyrosinase (1)

Vasopressin Receptor (1)

Wnt (3)

β-catenin (2)

By Research Areas:

Cancer (46)

Cardiovascular Disease (9)

Endocrinology (5)

Infection (2)

Inflammation/Immunology (10)

Metabolic Disease (2)

Neurological Disease (15)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Antibodies

SK-575	PARP PROTACs	Cancer
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC₅₀ of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations .

SK-3-91	Others	Cancer
SK-3-91 is a multi-kinase degrader. SK-3-91 could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) .

SK33	Androgen Receptor	Cancer
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity .

SK-575-NEG	PARP	Cancer
SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC₅₀ of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM .

SK609 hydrochloride	Dopamine Receptor	Neurological Disease
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC₅₀ of 1109 nM. SK609 hydrochloride has the potential for parkinson research .

SK-216	PAI-1	Cancer
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma .

SK1-IN-1 1 Publications Verification	SphK	Inflammation/Immunology Cancer
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

SK1-I 1 Publications Verification BML-258	SphK	Cancer
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a K_i value of 10 µM . SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .

SK1-I hydrochloride 1 Publications Verification BML-258 hydrochloride	SphK	Cancer
SK1-I hydrochloride (BML-258 hydrochloride), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a K_i value of 10 µM . SK1-I hydrochloride shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I hydrochloride enhances autophagy and has antitumor activity .

Lazuvapagon SK-1404; KRP-N118	Vasopressin Receptor	Others
Lazuvapagon (SK-1404) is a vasopressin V2 receptor agonist for the research of nocturia .

SK3 Channel-IN-1	Potassium Channel	Cancer
SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer .

Anagliptin 3 Publications Verification SK-0403	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

Anagliptin hydrochloride SK-0403 hydrochloride	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

Metiamide SK&F 92058	Histamine Receptor	Endocrinology
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

Mirodenafil SK3530	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

SKI-I	SphK Apoptosis	Cancer
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC₅₀ of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC₅₀=11 μM). SKI-I induces apoptosis in tumor cell lines .

SKI II 2 Publications Verification	SphK Wnt Apoptosis	Cancer
SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC₅₀ values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation .

Cefatrizine BL-S-640; SK&F 60771	Apoptosis Bacterial Antibiotic	Infection Cancer
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection .

Kallikrein, Porcine pancreas kininogenase; SK-827	Endogenous Metabolite	Others
Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively .

SKI V 1 Publications Verification
SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC₅₀ of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC₅₀ of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity .

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	DNA/RNA Synthesis	Cancer
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

Phen Green SK diacetate (5/6-mixture) 2 Publications Verification PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+. PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions

Bicuculline 15+ Cited Publications (+)-Bicuculline; d-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

Rimtuzalcap CAD-1883	Potassium Channel	Neurological Disease
Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca ²⁺-activated K ⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits *SK3*-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the *SK1-3* subtypes Ca ²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺), and does not affect the Ca ²⁺-activated K ⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively) .

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of *SK2* (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

Dihydroprehelminthosporol	Others	Cancer
Dihydroprehelminthosporol (Compound 1) from the fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on human cancer cell line A549 and SK-0A-3 has cytotoxicity .

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of *SK2* (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

NS13001	Potassium Channel	Neurological Disease
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC₅₀s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias .

3-epi-Isocucurbitacin B	Others	Cancer
3-epi-Isocucurbitacin B (Compound 5) is a cucurbitane triterpene derived from Trichosanthes kirilowii. 3-epi-Isocucurbitacin B shows significant cytotoxicity to human tumor cells A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15 .

Opaganib 5+ Cited Publications ABC294640	SphK	Cancer
Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with K_i of 9.8 μM.

Cepharadione B	Tyrosinase Endogenous Metabolite	Cancer
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells .

Norcepharadione B	Others	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

Antitumor agent-61	Apoptosis	Cancer
Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC₅₀s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways .

1α-Hydroxytorilin	Others	Others
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively .

Glucozaluzanin C	Others	Others
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED₅₀ value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .

NS309	Potassium Channel	Cardiovascular Disease Neurological Disease
NS309 is a potent and selective activator of the Ca ²⁺-activated SK/IK potassium channels, but displays no activity at BK channels .

Scutebata A	Others	Cancer
Scutebata A is a diterpenoid isolated from Scutellaria barbata that exhibits antitumor activity. Scutebata A is weakly cytotoxic against SK-BR-3 with an IC₅₀ value of 15.2 μM .

QC-182	PROTACs Histone Acetyltransferase	Cancer
QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC₅₀ = 93nM). QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC₅₀ values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC) .

Panaxyne	Others	Cancer
Panaxyne is a polyacetylene, that can be isolated from the roots of cultivated-wild ginseng. Panaxyne shows significant and selective cytotoxicity against SK-OV-3, with an ED₅₀ of 1.40 µM .

Apamin 3 Publications Verification Apamine	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

ICA N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine	Parasite	Infection Cardiovascular Disease
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC₅₀ of 2.1 µM.

Apamin TFA 3 Publications Verification Apamine TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

Exatecan-amide-cyclopropanol	ADC Cytotoxin	Cancer
Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC₅₀ values of 0.12 and 0.23 nM, respectively .

Cat. No.	Product Name

HY-L009

Kinase Inhibitor Library

3137 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3137 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of *SK2* (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P0256

Apamin 3 Publications Verification Apamine	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P0256A

Apamin TFA 3 Publications Verification Apamine TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P5436

SK-MLCK M13	Peptides	Others
SK-MLCK M13 is a biological active peptide. (M-13 is a peptide that represents CAM-binding domain of Calmodulin (CaM) target proteins. CaM is an ubiquitous Ca2+ binding protein.)

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of *SK2* (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P3064

Scyllatoxin Leiurotoxin I	Potassium Channel	Neurological Disease
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance K_Ca (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

Species:	Human (18) Virus (1) Rhesus Macaque (2) Mouse (2)
Tag:	His (12) Tag Free (4) Avi (9) Fc (7) B2M (1)
Source:	HEK293 (18) Sf9 insect cells (1) CHO (1) P. pastoris (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700885

	DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is 111 a.a., with molecular weight of 50-60 kDa.

HY-P700884

	DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is 89 a.a., with molecular weight of 50-55 kDa.

HY-P700705

	DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is 111 a.a., with molecular weight of 50-60 kDa.

HY-P700704

	DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is 89 a.a., with molecular weight of 45-55 kDa.

HY-P700863

	DKK1 Protein, Human (89a.a, HEK293, mFc) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK1 Protein, Human (89a.a, HEK293, mFc) is the recombinant human-derived DKK1 protein, expressed by HEK293, with C-mFc labeled tag. The total length of DKK1 Protein, Human (89a.a, HEK293, mFc) is 89 a.a., with molecular weight of 45-53 kDa.

HY-P75707

	DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Rhesus Macaque	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) is 266 a.a., with molecular weight of 38-43 kDa.

HY-P75708

	DKK-1 Protein, Rhesus Macaque (HEK293, Fc) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Rhesus Macaque	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, Fc) is 266 a.a., with molecular weight of 60-70 kDa.

HY-P72969

	DKK1 Protein, Mouse (HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Mouse	HEK293
	DKK1 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In addition to its Wnt-dependent role, DKK1 has Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. DKK1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK1 Protein, Mouse (HEK293, His) is 241 a.a., with molecular weight of ~38.29 kDa.

HY-P72968

	DKK-1 Protein, Human (HEK293, Fc) 2 Publications Verification Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (HEK293, Fc) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DKK-1 Protein, Human (HEK293, Fc) is 235 a.a., with molecular weight of ~60-80 kDa.

HY-P73513

	DKK1 Protein, Human (HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK1 Protein, Human (HEK293, His) is the recombinant human-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DKK1 Protein, Human (HEK293, His) is 235 a.a., with molecular weight of ~42.9 kDa.

HY-P7155B

	DKK-1 Protein, Human (235a.a, HEK293, Tag free) rHuDKK-1; hDkk-1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 Protein, Human (235a.a, HEK293, Tag free) is the recombinant human-derived DKK-1 protein, expressed by HEK293, with tag free. The total length of DKK-1 Protein, Human (235a.a, HEK293, Tag free) is 235 a.a., with molecular weight of ~38.31 kDa.

HY-P78430

	DKK1 Protein, Human (HEK293, His-Avi) Dickkopf-1; Dkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived DKK1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of DKK1 Protein, Human (HEK293, His-Avi) is 235 a.a., with molecular weight of 45-55 kDa.

HY-P7155A

	DKK-1 Protein, Human (HEK293, His) Maximum Cited Publications 7 Publications Verification rHuDKK-1; hDkk-1; SK	Human	HEK293
	Dkk-1 Protein, Human (HEK293) is involved in embryonic development through its inhibition of the Wnt signaling pathway.

HY-P71792

	TYR Protein, Human (P.pastoris, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag. The total length of TYR Protein, Human (P.pastoris, His) is 359 a.a., with molecular weight of ~48 kDa.

HY-P700940

	*HLA-A0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi)** MART1; LB39-AA; SK29-AA; Melan-A; MLANA	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MART-1 Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A*0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi), has molecular weight of 53-63 kDa.

HY-P73421

	SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with tag free. The total length of SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) is 384 a.a., with molecular weight of ~46 kDa.

HY-P700941

	*HLA-A0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi)** MART1; LB39-AA; SK29-AA; Melan-A; MLANA	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MART-1 Complex Tetramer protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A*0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P702765

SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a)

SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK
Human Sf9 insect cells

HY-P78494

	Nectin-1 Protein, Human (HEK293, His-Avi) CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR	Human	HEK293
	Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Nectin-1 Protein, Human (HEK293, His-Avi) is 304 a.a., with molecular weight of 52-70 kDa.

HY-P78179

	Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR	Human	HEK293
	Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 304 a.a., with molecular weight of 52-70 kDa.

HY-P7154

	DKK-1 Protein, Mouse (CHO) 4 Publications Verification rMuDKK-1; mDkk-1; Dickkopf-1	Mouse	CHO
	Dkk-1 Protein, Mouse (CHO) is shown to be a potent inhibitor of Wnt signaling and member of dickkopf family.

HY-P74923

	HA1/Hemagglutinin Protein, H7N3 (ACA25329, HEK293, His) Influenza A H7N3 (A/chicken/SK/HR-00011/2007) Hemagglutinin / HA1 Protein (His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways. As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane. HA1/Hemagglutinin Protein, H7N3 (ACA25329, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA1/Hemagglutinin Protein, H7N3 (ACA25329, HEK293, His) is 342 a.a., with molecular weight of ~36.7 kDa.

HY-P71544

	MLANA Protein, Human (His, B2M) Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A	Human	E. coli
	The MLANA protein is essential in melanosome biosynthesis, ensuring the stability of GPR143, and plays a key role in the expression, stability, transport, and processing of the melanocyte protein PMEL. Its interaction with PMEL and GPR143 highlights its integral role in the complex network required for second-stage melanosome formation. MLANA Protein, Human (His, B2M) is the recombinant human-derived MLANA protein, expressed by E. coli , with N-His, B2M labeled tag. The total length of MLANA Protein, Human (His, B2M) is 118 a.a., with molecular weight of ~27.2 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P82961

DKK1 Antibody (YA2706)

DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK
WB, IHC-P, ICC/IF, FC Human, Rat
HY-P82777

Tyrosinase Antibody (YA2522)

ATN; CMM8; LB24 AB; SHEP3; SK29 AB; Tumor rejection antigen AB; TYR
WB, IHC-P, ICC/IF Human
HY-P83295

MelanA Antibody (YA3040)

MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
WB, IHC-P, ICC/IF, FC Human

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