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Results for "

SK-MEL-28

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147855
    ACA-28

    		ERK Apoptosis Cancer
    ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively .
    ACA-<em>28</em>
  • HY-155315
    Tubulin polymerization-IN-51

    		Others Cancer
    Tubulin polymerization-IN-51(compound 7u) is a tubulin polymerization inhibitor with IC50 value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research .
    Tubulin polymerization-IN-51
  • HY-162045
    Ru-4T

    		Others Cancer
    Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC50 values of 740 pM .
    Ru-4T
  • HY-155314
    Tubulin polymerization-IN-50

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC50 of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase .
    Tubulin polymerization-IN-50
  • HY-W317408
    (+)-Menthyl acetate

    		Others Others
    (+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC50=34.0 μg?mL -1, and lower than that of SK-Mel-28 cell line, IC50=279.9 μg?mL -1, on A549 cell without fatal .
    (+)-Menthyl acetate
  • HY-150534
    Anti-melanoma agent 1

    		Apoptosis Cancer
    Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis .
    Anti-melanoma agent 1
  • HY-125097
    5'-Hydroxy-staurosporine

    		Others Cancer
    5'-Hydroxy-staurosporine is an indolocarbazole alkaloid that can be isolated from marine Micromonospora sp. (strain L-31-CLCO-002). 5'-Hydroxy-staurosporine can be used in tumor related research .
    5'-Hydroxy-staurosporine
  • HY-145859
    Topo I-IN-1

    		Topoisomerase Apoptosis Reactive Oxygen Species Cancer
    Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis .
    Topo I-IN-1
  • HY-148059
    Uplarafenib

    B-Raf IN 10

    		 Raf Cancer
    Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity .
    Uplarafenib
  • HY-112538
    1-(1-Naphthyl)piperazine hydrochloride

    1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride

    		 5-HT Receptor Apoptosis Inflammation/Immunology Cancer
    1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis .
    1-(1-Naphthyl)piperazine hydrochloride
  • HY-14454
    TPh A
    1 Publications Verification

    Triphenyl Compound A

    		 Others Cancer
    TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells .
    TPh A
  • HY-B0150
    Nicotinamide
    35+ Cited Publications

    Niacinamide; Nicotinic acid amide

    		 Organoid Endogenous Metabolite Sirtuin HBV Cancer
    Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
    Nicotinamide
  • HY-130602
    MS432

    		PROTACs MEK Cancer
    MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively .
    MS432
  • HY-N4006
    Isoangustone A

    		Apoptosis Autophagy Inflammation/Immunology Cancer
    Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death .
    Isoangustone A

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