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Results for "

SLF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AUTACs (2) Autophagy (1) FKBP (5) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (3) LPL Receptor (3) PROTACs (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (8) Inflammation/Immunology (4)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114872

*SLF*	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC₅₀ of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC .

HY-149004

SLF1081851 1 Publications Verification	LPL Receptor	Inflammation/Immunology
SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 plays a key role in development and immune system .

HY-114872A

SLF TFA	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC₅₀ of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC .

HY-149004B

SLF1081851 hydrochloride	LPL Receptor	Inflammation/Immunology
SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system .

HY-149004A

SLF1081851 TFA	LPL Receptor	Inflammation/Immunology
SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system .

HY-RS13361

SLF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLF1 Human Pre-designed siRNA Set A SLF1 Human Pre-designed siRNA Set A

HY-RS13362

SLF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLF2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLF2 Human Pre-designed siRNA Set A SLF2 Human Pre-designed siRNA Set A

HY-107452

SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs .

HY-129610

KB02-SLF	PROTACs FKBP	Cancer
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF .

HY-103634

dFKBP-1	PROTACs FKBP	Cancer
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker .

HY-134184

AUTAC2	AUTACs Autophagy	Inflammation/Immunology Cancer
AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .

HY-131385

KB02-COOH	Ligands for E3 Ligase	Cancer
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610) .

HY-150410

TSPO ligand-3	AUTACs	Cancer
TSPO ligand-3 is a ligand of AUTAC2. AUTAC2 contains an p-fluorobenzylguanine (FBnG) and an synthetic ligand of FKBP (SLF) moiety, which can cause significant silencing of FKBP12 in HeLa cells .

Species:	Human (2) Rat (2) Mouse (3)
Tag:	His (7)
Source:	HEK293 (3) Sf9 insect cells (1) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71130

	SCF Protein, Rat (HEK293, His) FPH2; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Rat	HEK293
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (HEK293, His) is the recombinant rat-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Rat (HEK293, His) is 164 a.a., with molecular weight of 23-40 kDa.

HY-P70555

	SCF Protein, Mouse (HEK293, His) FPH2; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Mouse	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (HEK293, His) is the recombinant mouse-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Mouse (HEK293, His) is 164 a.a., with molecular weight of 19-35 kDa.

HY-P72480

	SCF Protein, Rat (His) Kit ligand; MGF; SCF; c-Kit ligand; sKITLG; Kitlg	Rat	E. coli
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (His) is the recombinant rat-derived SCF protein, expressed by E. coli , with C-6*His labeled tag. The total length of SCF Protein, Rat (His) is 164 a.a., with molecular weight of ~17 kDa.

HY-P70757G

	GMP SCF Protein, Human (HEK293, His) Kit Ligand; MGF; SCF; c-Kit ligand; KITLG; sKITLG	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. GMP SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight of 30-50 kDa.

HY-P73410

	SCF Protein, Human (sf9, His) SCF; Hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Human	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (sf9, His) is the recombinant human-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Human (sf9, His) is 164 a.a., with molecular weight of ~22 kDa.

HY-P73662

	SCF Protein, Mouse (sf9, His) SCF; Hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Mouse (sf9, His) is 189 a.a., with molecular weight of ~23 kDa.

HY-P77529

	SCF Protein, Mouse (Biotinylated, sf9, His) SCF; Hematopoietic growth factor KL; MGF; Mast Cell Growth Factor	Mouse	Sf9 insect cells
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (Biotinylated, sf9, His) is the recombinant mouse-derived SCF protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SCF Protein, Mouse (Biotinylated, sf9, His) is 189 a.a., with molecular weight of ~19.7 KDa.


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