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Results for "

SMURF1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Peptides

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110195
    Smurf1-IN-A01
    3 Publications Verification

    A01

    		 HSP Interleukin Related MyD88 NF-κB Estrogen Receptor/ERR Others Cancer
    Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration [1] .
    Smurf1-IN-A01
  • HY-160928
    Smurf1 modulator-1

    		E1/E2/E3 Enzyme Cardiovascular Disease
    Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with IC50 of 180 nM [1].
    Smurf1 modulator-1
  • HY-169049
    Smurf1 ligand 1

    		Ligands for Target Protein for PROTAC Cancer
    Smurf1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Smurf1 ligand 1 can be used for synthesis SMART1 (HY-W998345) [1].
    Smurf1 ligand 1
  • HY-174416
    Smurf1-IN-5

    		E1/E2/E3 Enzyme Cardiovascular Disease
    Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) [1].
    Smurf1-IN-5
  • HY-149316
    Smurf1-IN-1

    		E1/E2/E3 Enzyme Cardiovascular Disease
    Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension [1].
    Smurf1-IN-1
  • HY-W998345
    SMART1

    		PROTACs PDK-1 Akt Cancer
    SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) [1].
    SMART1
  • HY-RS18717
    Smurf1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smurf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smurf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smurf1 Mouse Pre-designed siRNA Set A
    Smurf1 Mouse Pre-designed siRNA Set A
  • HY-RS13459
    SMURF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SMURF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMURF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SMURF1 Human Pre-designed siRNA Set A
    SMURF1 Human Pre-designed siRNA Set A
  • HY-RS25204
    Smurf1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smurf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smurf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smurf1 Rat Pre-designed siRNA Set A
    Smurf1 Rat Pre-designed siRNA Set A
  • HY-P5522A
    TriDAP dihydrochloride
    1 Publications Verification

    L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride

    		 NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV Infection Inflammation/Immunology
    TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP dihydrochloride enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP dihydrochloride downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP dihydrochloride decreases IκBα levels and increases p65 levels. TriDAP dihydrochloride induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP dihydrochloride increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP dihydrochloride can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection [1] .
    TriDAP dihydrochloride
  • HY-P5522
    TriDAP

    L-Ala-γ-D-Glu-meso-diaminopimelic acid

    		 NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV Infection Inflammation/Immunology
    TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP decreases IκBα levels and increases p65 levels. TriDAP induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection [1] .
    TriDAP
  • HY-157195
    Smurf-1-IN-3

    		E1/E2/E3 Enzyme Cardiovascular Disease
    Smurf-1-IN-3 is a selective Smurf-1 inhibitor with an IC50 value of 2.2 nM. Smurf-1-IN-3 can be used for the research of pulmonary arterial hypertension [1].
    Smurf-1-IN-3

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