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SOD1

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By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Dopamine β-hydroxylase (1) ROCK (1) Small Interfering RNA (siRNA) (1) SOD (3)
By Research Areas:	Cancer (2) Neurological Disease (7)

10

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SOD1-Derlin-1 inhibitor-2	Others	Neurological Disease
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of *SOD1-Derlin-1* interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1 ^mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS) ^[1].

SOD1-Derlin-1 inhibitor-1	Others	Neurological Disease
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of *SOD1-Derlin-1* interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 ^G93A-Derlin-1 complex with an IC₅₀ value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis ^[1].

Tofersen BIIB067; ISIS-SOD1Rx	DNA/RNA Synthesis	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of *superoxide dismutase 1 (SOD1) mRNA* to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) ^[1].

NUCC-0000323	SOD	Neurological Disease
NUCC-0000323 is a potent superoxide dismutase 1 (SOD1) inhibitor. NUCC-0000323 inhibits SOD1 expression. NUCC-0000323 can be used in research of amyotrophic lateral sclerosis (ALS) ^[1].

SOD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SOD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOD1 Human Pre-designed siRNA Set A SOD1 Human Pre-designed siRNA Set A

ATN-224 3 Publications Verification Bis(choline)tetrathiomolybdate	SOD	Cancer
ATN-224 is an oral Cu ²⁺/Zn ²⁺-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC₅₀ of 17.5±3.7 nM.

LCS-1	Apoptosis SOD	Cancer
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC₅₀ value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells ^[1] .

CMB-087229	Biochemical Assay Reagents	Neurological Disease
CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC₅₀ of 67 nM, which can be used in the research of amyotrophic lateral sclerosis ^[1].

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation ^[1].

Cuprizone 1 Publications Verification	Dopamine β-hydroxylase	Neurological Disease
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) ^[1].

Cat. No.	Compare	Product Name	Species	Source

	SOD1 Protein, Human (His) Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1; hSOD1; SOD1	Human	E. coli
	SOD1 Protein, an enzyme crucial for cellular defense, operates as a superoxide dismutase, neutralizing radicals to safeguard cells from oxidative stress. Its enzymatic activity underscores the importance of SOD1 in maintaining cellular homeostasis and protecting biological systems from the harmful effects of reactive oxygen species accumulation. SOD1 Protein, Human (His) is the recombinant human-derived SOD1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SOD1 Protein, Human (His) is 154 a.a., with molecular weight of ~20.0 kDa.

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