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Isoforms Recommended:	STAT3

Results for "

STAT3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Akt (5) AMPK (1) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (11) Apoptosis (74) Arginase (1) ATM/ATR (1) Autophagy (9) Bacterial (11) Bcl-2 Family (5) Bcr-Abl (1) c-Met/HGFR (4) c-Myc (2) Caspase (3) CDK (1) COX (4) CXCR (1) Cytochrome P450 (1) Dopamine Receptor (6) DYRK (1) EGFR (6) Endogenous Metabolite (13) Ephrin Receptor (1) Epigenetic Reader Domain (1) ERK (3) Estrogen Receptor/ERR (4) FAK (1) Ferroptosis (5) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (3) Histone Acetyltransferase (1) HIV (1) HSP (1) IGF-1R (1) IKK (2) Insulin Receptor (1) Interleukin Related (10) Isotope-Labeled Compounds (9) JAK (36) JNK (2) Keap1-Nrf2 (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (2) MicroRNA (1) Microtubule/Tubulin (3) MMP (1) mTOR (2) nAChR (1) NF-κB (10) NO Synthase (2) Oxidative Phosphorylation (1) p38 MAPK (3) Parasite (15) PARP (1) PD-1/PD-L1 (2) Phosphatase (2) PI3K (2) Potassium Channel (7) PPAR (2) Prostaglandin Receptor (1) PROTACs (3) PTEN (1) Pyroptosis (1) Pyruvate Kinase (1) RAR/RXR (1) Reactive Oxygen Species (5) ROCK (1) ROS Kinase (1) SARS-CoV (1) Sirtuin (3) Small Interfering RNA (siRNA) (3) Src (1) STAT (169) Survivin (1) TET Protein (2) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (1) TrxR (1) VEGFR (2) Virus Protease (4) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (195) Cardiovascular Disease (9) Endocrinology (5) Infection (25) Inflammation/Immunology (60) Metabolic Disease (7) Neurological Disease (14)
Click Chemistry:	Alkynes (1)

258

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

STAT3 degrader-2	STAT PROTACs	Cancer
STAT3 degrader-2 is a PROTAC-based degrader of *STAT3. STAT3* degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases . STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

STAT3 degrader-1	STAT	Cancer
STAT3 degrader-1 (compound 295) is a potent *STAT3* degrader. STAT3 degrader-1 can be used for researching anticancer . STAT3 degrader-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

STAT3-IN-24, cell-permeable PpYLKTK-mts; STAT3 PI	STAT	Cancer
STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a *STAT3* peptide inhibitor. STAT3-IN-24, cell-permeable inhibits recruitment of STAT3 to Jak2 and phosphorylation of Y705, thus preventing the dimerization and the nuclear translocation of STAT3 .

STAT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT3-IN-13	STAT Apoptosis Bcl-2 Family	Cancer
STAT3-IN-13 (compound 6f) is a potent *STAT3* inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a K_D of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces apoptosis in vitro and suppresses the growth and metastasis of tumor in vivo. STAT3-IN-13 can be used for cancer research .

STAT3-IN-14	STAT	Cancer
STAT3-IN-14 (Compound 1) is a *STAT3* inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3 .

STAT3-IN-11 1 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-11 (7a) is a selective *STAT3* inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers .

STAT3-IN-3 4 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .

STAT3-IN-20	STAT	Cancer
STAT3-IN-20 (Compound 40) is a selective *STAT3* inhibitor (IC₅₀: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC₅₀: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis .

STAT3-IN-4	STAT	Cancer
STAT3-IN-4 (compound B9) is a *STAT3* inhibitor with K_d values for *STAT3* (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells .

STAT3-IN-7	STAT	Cancer
STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active *STAT3* inhibitor. STAT3-IN-7 has anticancer activities (WO2021016333A1, H182) .

STAT3-SH2 domain inhibitor 1	STAT Apoptosis	Cancer
STAT3-SH2 domain inhibitor 1 is a potent *Src Homology 2 (SH2) Domain of STAT3* (STAT3-SH2 domain) inhibitor with a K_d** value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer .

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

STAT3-IN-5	STAT	Cancer
STAT3-IN-5 is a potent *STAT3* inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC₅₀ value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer .

STAT3-IN-10	STAT Apoptosis	Cancer
STAT3-IN-10 is a *STAT3* inhibitor with an IC₅₀ value of 5.18 µM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis .

STAT3-IN-9	Apoptosis STAT	Cancer
STAT3-IN-9 is a potent *STAT3* inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase .

STAT3-IN-8	STAT	Cancer
STAT3-IN-8 (compound H172) is a potent *STAT3* inhibitor. STAT3-IN-8 has the potential for cancer research .

STAT3-IN-15 1 Publications Verification	STAT	Inflammation/Immunology
STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). STAT3-IN-15 inhibits STAT3 phosphorylation. STAT3-IN-15 also inhibits the migration and deformation of epithelial cells induced by TGF-β1 and inhibit epithelial-mesenchymal transition (EMT) .

STAT3-IN-23	STAT	Cancer
STAT3-IN-23 (PYLKTK) is a potent STAT3* inhibitor .

STAT3-IN-12	STAT Apoptosis	Cancer
STAT3-IN-12 is a potent *STAT3* signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma .

STAT3-IN-18	STAT JAK Apoptosis COX	Cancer
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.

STAT3-IN-17	STAT	Infection Cancer
STAT3-IN-17 is a moderate *STAT3* inhibitor (IC₅₀=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori .

STAT3-IN-1 5+ Cited Publications
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active *STAT3* inhibitor, with IC₅₀ values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis .

STAT3-IN-21, cell-permeable, negative control	STAT	Cancer
STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection .

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

*PROTAC STAT3* degrader-2**	PROTACs STAT	Cancer
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC₅₀ of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research . PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

*EGFR/STAT3-IN-1*	EGFR STAT	Cancer
EGFR/STAT3-IN-1 (Compound 5k) is a dual inhibitor of EGFR/STAT3 with IC₅₀ values for EGFR and *STAT3* are 41 and 3.34 nM, respectively. EGFR/STAT3-IN-1 has antitumor activity .

*phospho-STAT3-IN-2*	STAT	Cancer
Phospho-STAT3-IN-2 (compound 4D) is a STAT3 inhibitor that effectively inhibits STAT3 phosphorylation. phospho-STAT3-IN-2 can significantly reduce tumor volume in mouse xenograft tumor models without drug toxicity to other organs and tissues .

*JAK2/STAT3-IN-1*	Interleukin Related	Cancer
JAK2/STAT3-IN-1 (compound (S)-10a) is a potent GP130 inhibitor with an IC₅₀ of 3.04 µM. JAK2/STAT3-IN-1 shows anti-tumor activity .

*α7 nAchR-JAK2-STAT3* agonist 1**	nAChR JAK STAT NO Synthase	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

SD-1029	JAK STAT	Cancer
SD-1029 is a *JAK2/STAT3* inhibitor . SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation .

Ochromycinone 1 Publications Verification (Rac)-STA-21	STAT Bacterial	Infection Cancer
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a *STAT3* inhibitor. Ochromycinone can inhibits *STAT3* DNA binding activity, *STAT3* dimerization. Ochromycinone has anticancer and antimicrobial activity .

Angoline 1 Publications Verification	STAT	Cancer
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

Angoline hydrochloride	STAT	Cancer
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

STX-0119	STAT	Cancer
STX-0119 is a selective, orally active *STAT3* dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC₅₀ of 74 μM .

5,15-Diphenylporphyrin 5,15-DPP	STAT	Cancer
5,15-Diphenylporphyrin (5,15-DPP) is a selective *STAT3-SH2* antagonist (IC₅₀s of 0.28 µM and 10 µM for STAT3 and STAT1, respectively) .

Eucannabinolide Hiyodorilactone A; Schkuhrin I	STAT	Cancer
Eucannabinolide is a *STAT3* inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research .

MM-206	STAT	Cancer
MM-206, a *STAT3* activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC₅₀ of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines .

NT219	Insulin Receptor STAT	Cancer
NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and *STAT3. IRS1/2 and STAT3* are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases .

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Reticuline shows anti-inflammatory effects through *JAK2/STAT3* and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 1 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of *STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3* inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects .

Prosapogenin A Progenin III	Apoptosis	Cancer
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

Matairesinol monoglucoside	Others	Others
Matairesinol monoglucoside, a lignan compound, exhibits low activity on *IFN-γ/STAT1* and *IL-6/STAT3* signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively .

Ac-GpYLPQTV-NH2	STAT	Cancer
Ac-GpYLPQTV-NH2 is a *STAT3* inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .

Cat. No.	Product Name

HY-L008

JAK/STAT Compound Library

419 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 419 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Type

HY-B0497G

Niclosamide (GMP)

BAY2353 (GMP)

Fluorescent Dye

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells ^[3] .

Cat. No.	Product Name	Type

HY-B0497G

Niclosamide (GMP)

BAY2353 (GMP)

Biochemical Assay Reagents

HY-113066C

Guanosine 5'-diphosphate sodium

GDP sodium

Biochemical Assay Reagents

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

Cat. No.	Product Name	Target	Research Area

HY-P10114

STAT3-IN-24, cell-permeable PpYLKTK-mts; STAT3 PI	STAT	Cancer
STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a *STAT3* peptide inhibitor. STAT3-IN-24, cell-permeable inhibits recruitment of STAT3 to Jak2 and phosphorylation of Y705, thus preventing the dimerization and the nuclear translocation of STAT3 .

HY-P10113

STAT3-IN-23

STAT Cancer

STAT3-IN-23 (PY*LKTK) is a potent STAT3 inhibitor .
HY-P10099

STAT3-IN-21, cell-permeable, negative control

STAT Cancer

STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection .
HY-P10096

STAT3-IN-22, negative control

PYLKTK
Peptides Others

STAT3-IN-22, negative control (PYLKTK) is a peptide that serves as a control peptide for phosphotyrosine .

HY-P10115

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

HY-P10101

*APT STAT3, scrambled* APTscr	Peptides	Others
APT STAT3, scrambled (APTscr), a control peptide of STAT3-specific aptide (APT_STAT3), does not bind STAT3. APT STAT3, scrambled contains the same trpzip scaffold but with a scrambled sequence in the target-binding site .

HY-P10201

Ac-GpYLPQTV-NH2

STAT Cancer

Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking *STAT3* phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-P1061

Colivelin Maximum Cited Publications 34 Publications Verification	STAT Amyloid-β	Neurological Disease
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

HY-P1061A

Colivelin TFA Maximum Cited Publications 34 Publications Verification	STAT Amyloid-β Apoptosis	Neurological Disease
Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

HY-P10202

5-FAM-GpYLPQTV-NH2

STAT Cancer

5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 can be used in cancer research .

HY-P10202A

5-FAM-GpYLPQTV-NH2 TFA	STAT	Cancer
5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide and has *STAT3* inhibitory activity. 5-FAM-GpYLPQTV-NH2 (TFA) can be used in cancer research .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits *STAT3* signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) ^[3].

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

Cat. No.	Product Name	Target	Research Area

HY-P99507

Zenocutuzumab MCLA-128; PB4188; R040517	EGFR	Cancer
Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and *HER3* .

HY-P99917

Eflepedocokin alfa	STAT	Inflammation/Immunology
Eflepedocokin alfa is a recombinant fusion protein with potential cell protective activity. Eflepedocokin alfa consists of human IL-22 fused to human IgG2-Fc domain. Eflepedocokin alfa leads to the activation of IL-22/IL-22R-mediated signal transduction pathways as well as *STAT3*. Eflepedocokin alfa plays a role in immune response and bacterial infection, enhancing intestinal barrier function, intestinal immunity, and tissue repair .

Species:	Human (3)
Tag:	His (3) SUMO (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P70574

	STAT3 Protein, Human (His) Signal Transducer and Activator of Transcription 3; Acute-Phase Response Factor; STAT3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT3 Protein, Human (His) is 175 a.a., with molecular weight of 19 & 46 kDa, respectively.

HY-P701097

	STAT3 Protein, Human (His-Sumo) Signal Transducer and Activator of Transcription 3; Acute-Phase Response Factor; STAT3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His-Sumo) is the recombinant human-derived STAT3 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of STAT3 Protein, Human (His-Sumo) is 191 a.a., with molecular weight of ~38.3 kDa.

HY-P701098

	STAT3 Protein, Human (Full Length, His) STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (Full Length, His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of STAT3 Protein, Human (Full Length, His) is 770 a.a., with molecular weight of ~92.1 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80857

*Phospho-STAT3* (Tyr705) Antibody** STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Phospho-STAT3 (Tyr705) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 88 kDa, targeting to Phospho-STAT3 (Tyr705). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80344

STAT3 Antibody (YA056)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
STAT3 Antibody (YA056) is a non-conjugated and Rabbit origined monoclonal antibody about 88 kDa, targeting to STAT3. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80902

STAT3 Antibody (YA666) STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P	Human, Rat, Mouse
STAT3 Antibody (YA666) is a non-conjugated and Mouse origined monoclonal antibody about 88 kDa, targeting to STAT3 (6H10). It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat, Mouse.

HY-P80281

*Phospho-STAT3* (Ser727) Antibody**	WB, ICC/IF, IHC-P, IP	Human, Rat, Mouse
Phospho-STAT3 (Ser727) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 88 kDa, targeting to Phospho-STAT3 (S727). It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Rat, Mouse.

HY-P80282

*Phospho-STAT3* (Tyr705) Antibody (YA146)**	WB, IHC-P, IP	Human, Mouse
Phospho-STAT3 (Tyr705) Antibody (YA146) is a non-conjugated and Rabbit origined monoclonal antibody about 88 kDa, targeting to Phospho-STAT3(Tyr705). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse.

Cat. No.	Product Name		Classification

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

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