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Results for "

SUV

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

2

Peptides

2

Natural
Products

1

Recombinant Proteins

1

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100201
    A-196
    Maximum Cited Publications
    11 Publications Verification

    		 Histone Methyltransferase Cancer
    A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity .
    A-196
  • HY-150190
    F5446
    1 Publications Verification

    		 Histone Methyltransferase Apoptosis Cancer
    F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo .
    F5446
  • HY-N5072
    Desmethylglycitein
    3 Publications Verification

    4',6,7-Trihydroxyisoflavone

    		 CDK PI3K PKC Cancer
    Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .
    Desmethylglycitein
  • HY-15647
    BRD9539
    1 Publications Verification

    		 Histone Methyltransferase Cancer
    BRD9539 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 .
    BRD9539
  • HY-122181
    OTS186935
    4 Publications Verification

    		 Histone Methyltransferase Cancer
    OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells .
    OTS186935
  • HY-13807
    UNC0646
    1 Publications Verification

    		 Histone Methyltransferase Cancer
    UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM .
    UNC0646
  • HY-122182
    OTS193320

    		Histone Methyltransferase Apoptosis Cancer
    OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX .
    OTS193320
  • HY-122181B
    OTS186935 hydrochloride
    4 Publications Verification

    		 Histone Methyltransferase Cancer
    OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells .
    OTS186935 hydrochloride
  • HY-N5072R
    Desmethylglycitein (Standard)

    4',6,7-Trihydroxyisoflavone (Standard)

    		 Reference Standards CDK PI3K PKC Cancer
    Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .
    Desmethylglycitein (Standard)
  • HY-RS14052
    SUV39H2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUV39H2 Human Pre-designed siRNA Set A contains three designed siRNAs for SUV39H2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUV39H2 Human Pre-designed siRNA Set A
    SUV39H2 Human Pre-designed siRNA Set A
  • HY-RS18319
    Suv39h2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Suv39h2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Suv39h2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Suv39h2 Mouse Pre-designed siRNA Set A
    Suv39h2 Mouse Pre-designed siRNA Set A
  • HY-RS24797
    Suv39h2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Suv39h2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Suv39h2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Suv39h2 Rat Pre-designed siRNA Set A
    Suv39h2 Rat Pre-designed siRNA Set A
  • HY-RS14051
    SUV39H1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUV39H1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUV39H1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUV39H1 Human Pre-designed siRNA Set A
    SUV39H1 Human Pre-designed siRNA Set A
  • HY-RS17179
    Suv39h1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Suv39h1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Suv39h1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Suv39h1 Mouse Pre-designed siRNA Set A
    Suv39h1 Mouse Pre-designed siRNA Set A
  • HY-122181A
    OTS186935 trihydrochloride

    		Histone Methyltransferase Cancer
    OTS186935 trihydrochloride is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 trihydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS186935 trihydrochloride regulates the production of γ-H2AX in cancer cells .
    OTS186935 trihydrochloride
  • HY-RS23629
    Suv39h1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Suv39h1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Suv39h1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Suv39h1 Rat Pre-designed siRNA Set A
    Suv39h1 Rat Pre-designed siRNA Set A
  • HY-100201R
    A-196 (Standard)

    		Histone Methyltransferase Reference Standards Cancer
    A-196 (Standard) is the analytical standard of A-196 (HY-100201). This product is intended for research and analytical applications. A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity .
    A-196 (Standard)
  • HY-133567
    SET7-IN-DC21

    		Histone Methyltransferase Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer .
    SET7-IN-DC21
  • HY-P11180
    Clavanin A

    		Antibiotic Bacterial Infection
    Clavanin A is a peptide Antibiotic and membrane permeabilizer. Clavanin A permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A exhibits antibacterial activity against Micrococcus flavus. Clavanin A can be used in studies related to Micrococcus flavus infection .
    Clavanin A
  • HY-P11180A
    Clavanin A acetate

    		Antibiotic Bacterial Infection
    Clavanin A acetate is a peptide Antibiotic and membrane permeabilizer. Clavanin A acetate permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A acetate inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A acetate exhibits antibacterial activity against Micrococcus flavus. Clavanin A acetate can be used in studies related to Micrococcus flavus infection .
    Clavanin A acetate

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