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Sepiapterin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (1) Endogenous Metabolite (7) Isotope-Labeled Compounds (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (2) Metabolic Disease (6)

9

Inhibitors & Agonists

3

Natural
Products

2

Recombinant Proteins

4

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Homovanillic acid Vanilacetic acid	Endogenous Metabolite	Metabolic Disease
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

QM385 2 Publications Verification	Others	Inflammation/Immunology
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC₅₀ of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability .

Homovanillic acid-d5 Vanilacetic acid-d₅	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₅ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid-d3 Vanilacetic acid-d₃	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

L-Sepiapterin Sepiapterin	Endogenous Metabolite	Cancer
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression .

Homovanillic acid-d2 Vanilacetic acid-d₂	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d₂ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid (Standard) Vanilacetic acid (Standard)	Drug Metabolite Endogenous Metabolite	Metabolic Disease
Homovanillic acid (Standard) is the analytical standard of Homovanillic acid. This product is intended for research and analytical applications. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid-13C6,18O	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Homovanillic acid- ¹³C₆, ¹⁸O is the ¹³C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

SPR inhibitor 3 SPRi3	Others	Inflammation/Immunology
SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC₅₀=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC₅₀=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels .

Cat. No.	Product Name	Category	Target	Chemical Structure

Homovanillic acid Vanilacetic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endocrine diseases Endogenous metabolite Monophenols Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Phenols Nervous System Disorder Disease Research Fields	Endogenous Metabolite
Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

L-Sepiapterin Sepiapterin	Alkaloids Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression .

Homovanillic acid (Standard) Vanilacetic acid (Standard)	Structural Classification Monophenols Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite	Drug Metabolite Endogenous Metabolite
Homovanillic acid (Standard) is the analytical standard of Homovanillic acid. This product is intended for research and analytical applications. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	SPR Protein, Human SPR; Sepiapterin reductase; SPR	Human	E. coli
	SPR proteins play a key role in tetrahydrobiopterin biosynthesis by catalyzing the final one or two reductions required to form 5,6,7,8-tetrahydrobiopterin. This enzyme activity is critical for the production of tetrahydrobiopterin, a cofactor involved in various biochemical pathways, including neurotransmitter synthesis and nitric oxide production. SPR Protein, Human is the recombinant human-derived SPR protein, expressed by E. coli , with tag free. The total length of SPR Protein, Human is 261 a.a., .

	SPR Protein, Human (His) SPR; Sepiapterin reductase; SPR	Human	E. coli
	SPR proteins play a key role in tetrahydrobiopterin biosynthesis by catalyzing the final one or two reductions required to form 5,6,7,8-tetrahydrobiopterin. This enzyme activity is critical for the production of tetrahydrobiopterin, a cofactor involved in various biochemical pathways, including neurotransmitter synthesis and nitric oxide production. SPR Protein, Human (His) is the recombinant human-derived SPR protein, expressed by E. coli , with N-6*His labeled tag. The total length of SPR Protein, Human (His) is 261 a.a., .

Cat. No.	Product Name	Chemical Structure

Homovanillic acid-d5
Homovanillic acid-d₅ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid-d3
Homovanillic acid-d₃ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid-d2
Homovanillic acid-d₂ is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

Homovanillic acid-13C6,18O
Homovanillic acid- ¹³C₆, ¹⁸O is the ¹³C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

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