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Isoforms Recommended:	SIRT2

Results for "

Sirt2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (10) Autophagy (6) c-Myc (1) CMV (1) Dihydroorotate Dehydrogenase (3) Endogenous Metabolite (2) HBV (2) HDAC (1) Histone Demethylase (1) HSP (3) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (3) Microtubule/Tubulin (1) Organoid (1) Parasite (2) Phosphatase (2) Phospholipase (1) PROTACs (1) Reverse Transcriptase (2) SARS-CoV (3) Sirtuin (52) Small Interfering RNA (siRNA) (3) Topoisomerase (2)
By Research Areas:	Cancer (36) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (11)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

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Products

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS12940

SIRT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SIRT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIRT2 Human Pre-designed siRNA Set A SIRT2 Human Pre-designed siRNA Set A

HY-RS12941

Sirt2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt2 Mouse Pre-designed siRNA Set A Sirt2 Mouse Pre-designed siRNA Set A

HY-RS12942

Sirt2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sirt2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sirt2 Rat Pre-designed siRNA Set A Sirt2 Rat Pre-designed siRNA Set A

HY-119857

AGK7 Sirt2 Inhibitor,Inactive Control	Sirtuin	Neurological Disease
AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease .

HY-162252

SIRT2-IN-12

Sirtuin Others

SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC₅₀ value of 50 μM .
HY-115979

Sirt2-IN-5

Sirtuin Neurological Disease Cancer

Sirt2-IN-5 is a potent SIRT2 inhibtor .

SIRT2-IN-12	Sirtuin	Others
SIRT2-IN-12 (Compound 3) is a *SIRT2* inhibitor with a IC₅₀ value of 50 μM .

Sirt2-IN-5	Sirtuin	Neurological Disease Cancer
Sirt2-IN-5 is a potent *SIRT2* inhibtor .

HY-151185

Sirt2-IN-7	Sirtuin	Cancer
Sirt2-IN-7 (compound 22) is a selective inhibitor of *SIRT2. Sirt2-IN-7 inhibits SIRT2* with an IC₅₀ value and a K_i value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer .

HY-107660

SIRT2-IN-8

Sirtuin Neurological Disease

SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research .
HY-145958

Sirt2-IN-6

Sirtuin Cancer

Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC₅₀ of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer .

SIRT2-IN-8	Sirtuin	Neurological Disease
SIRT2-IN-8 is a potent *SIRT2* inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research .

Sirt2-IN-6	Sirtuin	Cancer
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of *SIRT2, with an IC₅₀* of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer .

HY-151522

SIRT2-IN-10	Sirtuin	Neurological Disease Cancer
SIRT2-IN-10 (Compound 12) is a potent *SIRT2* inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease .

HY-112427

Sirt2-IN-1

Sirtuin Inflammation/Immunology Cancer

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC₅₀ of 163 nM .
HY-112428

Sirt2-IN-2

Sirtuin Inflammation/Immunology

Sirt2-IN-2 (Compound 10) is a selective Sirt2 inhibitor with an IC₅₀ of 0.118 μM .
HY-160617

SIRT2-IN-14

Sirtuin Neurological Disease

SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC₅₀ of 0.196 μM .

Sirt2-IN-1	Sirtuin	Inflammation/Immunology Cancer
Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC₅₀ of 163 nM .

Sirt2-IN-2	Sirtuin	Inflammation/Immunology
Sirt2-IN-2 (Compound 10) is a selective *Sirt2* inhibitor with an IC₅₀ of 0.118 μM .

SIRT2-IN-14	Sirtuin	Neurological Disease
SIRT2-IN-14 (Compound 78) is a selectve inhibitor for *SIRT2* with an IC₅₀ of 0.196 μM .

HY-148408

SIRT2-IN-11	Sirtuin	Cancer
SIRT2-IN-11 (AEM1) is a selective *SIRT2* inhibitor with an IC₅₀ value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers .

HY-151519

SIRT2-IN-9	Sirtuin	Cancer
SIRT2-IN-9 (compound 12) is a selective inhibitor of *SRIT2* with an IC₅₀ value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer .

HY-123194

SIRT2/6-IN-1	Histone Demethylase Sirtuin	Metabolic Disease
SIRT2/6-IN-1 (Compound 5) is a *SIRT6/SIRT2* inhibitor, with IC₅₀s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells .

HY-103636

*PROTAC Sirt2* Degrader-1**	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a *Sirt2* degrader, composed of a highly potent and isotype-selective *Sirt2* inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM) .

HY-149637

*HSP70/SIRT2-IN-1*	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC₅₀ of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity .

HY-149638

*HSP70/SIRT2-IN-2*	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC₅₀ of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity .

HY-118343

AC-93253

Sirtuin Cancer

AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC₅₀ value of 6 μM. AC93253 can be used for the research of tumors .
HY-147233

MIND4-19

Sirtuin Neurological Disease

MIND4-19 is a potent SIRT2 inhibitor with an IC₅₀ value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease .
HY-139144

YM-08

Sirtuin HSP Neurological Disease Cancer

YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC₅₀ of 19.9 μM. YM-08 also is inhibitor of Hsp70 .

AC-93253	Sirtuin	Cancer
AC-93253 is a selective, potent *SIRT2* inhibitor. AC93253 can inhibit SIRT2 with an IC₅₀ value of 6 μM. AC93253 can be used for the research of tumors .

MIND4-19	Sirtuin	Neurological Disease
MIND4-19 is a potent *SIRT2* inhibitor with an IC₅₀ value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease .

YM-08	Sirtuin HSP	Neurological Disease Cancer
YM-08 (Compounds 7a) is a brain-penetrant inhibitors of *SIRT2*,with the IC₅₀ of 19.9 μM. YM-08 also is inhibitor of Hsp70 .

HY-107453

SirReal1-O-propargyl PROTAC Sirt2-binding moiety 1	Ligands for Target Protein for PROTAC	Cancer
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC₅₀ of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155392

Mz325	HDAC Sirtuin	Cancer
Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC₅₀ of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration .

HY-101278

Thiomyristoyl

5 Publications Verification

Sirtuin Cancer

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC₅₀ of 28 nM.

Thiomyristoyl 5 Publications Verification	Sirtuin	Cancer
Thiomyristoyl is a potent and specific *SIRT2* inhibitor with an IC₅₀ of 28 nM.

HY-111522

RK-9123016	Sirtuin c-Myc	Cancer
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC₅₀ value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression .

HY-16691

AK-7

1 Publications Verification

Sirtuin Neurological Disease

AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC₅₀ of 15.5 μM.
HY-101073

Salermide

2 Publications Verification

Sirtuin Apoptosis Cancer

Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
HY-101465

AK-1

Sirtuin Neurological Disease

AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC₅₀ of 12.5 μM.

AK-7 1 Publications Verification	Sirtuin	Neurological Disease
AK-7 is a selective cell- and brain-permeable *SIRT2* inhibitor, with an IC₅₀ of 15.5 μM.

Salermide 2 Publications Verification	Sirtuin Apoptosis	Cancer
Salermide is an inhibitor of *Sirt1* and *Sirt2*; can cause strong cancer-specific apoptotic cell death.

AK-1	Sirtuin	Neurological Disease
AK-1 is a potent, specific and cell-permeable *SIRT2* inhibitor, with an IC₅₀ of 12.5 μM.

HY-133998

SIRT-IN-3 1 Publications Verification	Sirtuin	Cancer
SIRT-IN-3 is a potent *SIRT* inhibitor, with an IC₅₀ of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC₅₀ of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) .

HY-15145A

SRT 1720 dihydrochloride 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and *SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀* of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-15145

SRT 1720 monohydrochloride 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 monohydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .

HY-100578

AGK2 5+ Cited Publications	Sirtuin Apoptosis	Cancer
AGK2 is a selective *SIRT2* inhibitor with an IC₅₀ of 3.5 μM. AGK2 inhibits *SIRT1* and *SIRT3* with IC₅₀s of 30 and 91 μM, respectively.

HY-108986

JFD00244

Sirtuin SARS-CoV Cancer

JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2 ^[2].

JFD00244	Sirtuin SARS-CoV	Cancer
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against *SARS-CoV-2* ^[2].

HY-100732

Cambinol 1 Publications Verification	Sirtuin Apoptosis Phospholipase	Cancer
Cambinol is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) ^[2].

HY-N1926

Dihydrocoumarin Hydrocoumarin; Chroman-2-one
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and *SIRT2* with IC₅₀s of 208 μM and 295 μM, respectively .

HY-10532

SRT 1720 30+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 is a selective activator of human *SIRT1* with an EC_1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC_1.5s of 37 μM and > 300 μM, respectively.

HY-100591

SirReal2 2 Publications Verification
SirReal2 is a potent, isotype-selective *Sirt2* inhibitor with an IC₅₀ value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1 .

HY-N9892

Guttiferone G	Sirtuin	Others
Guttiferone G inhibits recombinant human *SIRT1* and *SIRT2* (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla ^[2].

HY-13423

Tenovin-1 3 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor ^[2].

HY-136199

SIRT1-IN-1 1 Publications Verification	Sirtuin CMV	Infection
SIRT1-IN-1 is a selective *SIRT1* inhibitor with an IC₅₀ of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC₅₀ of 11.5 μM . SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity ^[2].

HY-B0150

Nicotinamide Maximum Cited Publications 36 Publications Verification Niacinamide; Nicotinic acid amide	Organoid Endogenous Metabolite Sirtuin HBV	Cancer
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits *SIRT2* activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity ^[2] .

HY-124037

SRT 1460 1 Publications Verification	Sirtuin	Cancer
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues .

HY-B0150A

Nicotinamide Hydrochloride Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride
Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits *SIRT2* activity (IC₅₀: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD₊, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity ^[2] .

HY-150568

SIRT1/2/3-IN-1	Sirtuin
SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of *SIRT1, SIRT2* and *SIRT3* with IC₅₀s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer .

HY-15510

Tenovin-6 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) ^[2].

HY-15510B

Tenovin-6 Hydrochloride 4 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) ^[2].

HY-107454

OSS_128167 10+ Cited Publications	Sirtuin HBV	Infection Metabolic Disease Inflammation/Immunology Cancer
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for *SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV* activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects ^[2].

HY-155729

Sirt1/2-IN-4	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC₅₀s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity .

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