Search Result

Pathways Recommended:	TGF-beta/Smad

Results for "

Smad

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-beta/Smad (31) Akt (1) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (2) Apoptosis (8) Autophagy (1) Bacterial (1) c-Myc (1) DNA/RNA Synthesis (1) DYRK (1) Endogenous Metabolite (6) ERK (2) Fungal (1) Glucosidase (1) HIF/HIF Prolyl-Hydroxylase (1) Integrin (2) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (2) NOD-like Receptor (NLR) (4) p38 MAPK (1) PD-1/PD-L1 (1) PI3K (1) Potassium Channel (5) Prostaglandin Receptor (1) PROTACs (1) Protease Activated Receptor (PAR) (2) Proton Pump (1) Reactive Oxygen Species (6) ROS Kinase (1) Small Interfering RNA (siRNA) (8) STAT (1) TGF-β Receptor (17) VEGFR (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (13) Endocrinology (3) Infection (5) Inflammation/Immunology (19) Metabolic Disease (12) Neurological Disease (2)

By Targets:

TGF-beta/Smad (31)

Akt (1)

Anaplastic lymphoma kinase (ALK) (2)

Antibiotic (2)

Apoptosis (8)

Autophagy (1)

Bacterial (1)

c-Myc (1)

DNA/RNA Synthesis (1)

DYRK (1)

Endogenous Metabolite (6)

ERK (2)

Fungal (1)

Glucosidase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Integrin (2)

Isotope-Labeled Compounds (1)

JNK (1)

Keap1-Nrf2 (1)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

NF-κB (2)

NOD-like Receptor (NLR) (4)

p38 MAPK (1)

PD-1/PD-L1 (1)

PI3K (1)

Potassium Channel (5)

Prostaglandin Receptor (1)

PROTACs (1)

Protease Activated Receptor (PAR) (2)

Proton Pump (1)

Reactive Oxygen Species (6)

ROS Kinase (1)

Small Interfering RNA (siRNA) (8)

STAT (1)

TGF-β Receptor (17)

VEGFR (1)

By Research Areas:

Cancer (29)

Cardiovascular Disease (13)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (19)

Metabolic Disease (12)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

SMAD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD2 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD3 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD4 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD5 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD6 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD7 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD9 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP signaling agonist sb4 3 Publications Verification	TGF-β Receptor	Cancer
BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC₅₀ value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding, Id1 and Id3) canonical BMP signaling .

SB-431542	TGF-β Receptor	Neurological Disease Cancer
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling .

Methacycline hydrochloride 2 Publications Verification	Bacterial Antibiotic	Infection
Methacycline hydrochloride is a tetracycline antibiotic and can inhibits bacterial protein synthesis. Methacycline hydrochloride is a potent epithelial-mesenchymal transition (EMT) inhibitor. Methacycline hydrochloride blocks EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. Methacycline hydrochloride is an antimicrobial and has the potential for pulmonary fibrosis .

Chebulinic acid 1 Publications Verification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

Myristoyl tetrapeptide-12	TGF-beta/Smad	Metabolic Disease
Myristoyl tetrapeptide-12 directly activates *SMAD2* and induces the linking of SMAD3 with DNA. Myristoyl tetrapeptide-12 is capable of stimulating hair growth, especially at the level of eyelashes .

BT173	DYRK	Cancer
BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway .

(E/Z)-SIS3 free base	TGF-beta/Smad	Inflammation/Immunology
E/Z-SIS3 free base exhibits an inhibitory efficacy against *smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad*3 signaling pathway .

SIS3 Maximum Cited Publications 72 Publications Verification	TGF-beta/Smad	Inflammation/Immunology
(E)-SIS3 is a potent and selective inhibitor of *Smad3* with an IC₅₀ of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .

Asiaticoside 5+ Cited Publications	TGF-beta/Smad Reactive Oxygen Species Apoptosis Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses *TGF-β/Smad* signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

TP0427736	TGF-β Receptor	Cancer
TP0427736 is a selective inhibitor of ALK5 with an IC₅₀ of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells .

SIS3 free base Maximum Cited Publications 72 Publications Verification
SIS3 free base is a potent and selective inhibitor of *Smad3* phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .

Luspatercept ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits *Smad2/3* signaling. Luspatercept can be used for the research of anemia .

MY-673	Microtubule/Tubulin Apoptosis ERK TGF-beta/Smad	Cancer
MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. MY-673 inhibits the ERK signaling pathway, which in turn affects SMAD4 protein expression levels in the TGF-β/SMAD pathway. MY-673 inhibited cell proliferation, migration and induced apoptosis in vivo and in vitro .

ML347 5 Publications Verification LDN 193719	TGF-β Receptor	Cancer
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC₅₀ values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1 .

PLN-1474	Integrin	Inflammation/Immunology
PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.

ENMD-1068 hydrochloride 1 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting *TGF-β1/Smad* signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis .

ENMD-1068	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting *TGF-β1/Smad* signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis .

TP0427736 hydrochloride	TGF-β Receptor	Endocrinology
TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC₅₀ of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC₅₀=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC₅₀ value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) .

3,3-Dimethyl-1-butanol DMB; Neohexanol	TGF-beta/Smad NF-κB Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and *TGF-β1/Smad3*. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

Carotuximab TRC105; DE-122	TGF-beta/Smad	Cancer
Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions .

ALK5-IN-8	TGF-β Receptor	Cancer
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1) .

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

J-1048	Anaplastic lymphoma kinase (ALK)	Others
J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway .

ALK5-IN-25	TGF-β Receptor	Cancer
ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor with an IC₅₀ ≤10 nM.ALK5-IN-25 also inhibits ALK-2 (selectivity ALK2/ALK5≤10). ALK5-IN-25 can be used for the research of cancer .

ALK5-IN-26	Others	Cancer
ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 with an IC₅₀ value ≤10 nM. ALK5-IN-26 can be used for the research of cancer .

Mollugin 1 Publications Verification	NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc	Cancer
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .

Chromenone 1	TGF-β Receptor	Others
Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs .

Caerulomycin A 1 Publications Verification Cerulomycin; Caerulomycin	Fungal Antibiotic	Infection Inflammation/Immunology
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases .

Higenamine hydrochloride 1 Publications Verification Norcoclaurine hydrochloride	MDM-2/p53 ROS Kinase Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Higenamine hydrochloride is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

Mongersen GED-0301	TGF-beta/Smad	Inflammation/Immunology
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .

Oxymatrine 10+ Cited Publications	TGF-beta/Smad Apoptosis	Infection Inflammation/Immunology Cancer
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and *TGF-β/Smad* pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.

AZ12601011 1 Publications Verification	TGF-β Receptor	Cancer
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC₅₀ of 18 nM and a K_d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth .

Trabedersen sodium AP 12009 sodium	TGF-beta/Smad	Cancer
Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

Trabedersen AP 12009	TGF-beta/Smad	Cancer
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

Hydrochlorothiazide 2 Publications Verification HCTZ	TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease Cancer
Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming *TGF-β/Smad* signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

Butaprost	Prostaglandin Receptor TGF-beta/Smad	Endocrinology
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering *TGF-β/Smad2* signalling .

R-268712	TGF-β Receptor TGF-beta/Smad Anaplastic lymphoma kinase (ALK)	Cardiovascular Disease Inflammation/Immunology Cancer
R-268712 is an orally active and selective ALK-5 inhibitor, with an IC₅₀ of 2.5 nM. R-268712 inhibits the phosphorylation of *Smad3* in a dose-dependent manner with an IC₅₀ of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer .

Hydrochlorothiazid-d2 HCTZ-d₂	TGF-beta/Smad Potassium Channel	Cardiovascular Disease Metabolic Disease
Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

223 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 223 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L103

Anti-Colorectal Cancer Compound Library

1618 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 1618 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-10431G

SB-431542 (GMP)	Fluorescent Dye
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling .

Cat. No.	Product Name	Type

HY-10431G

SB-431542 (GMP)	Biochemical Assay Reagents
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling .

Cat. No.	Product Name	Target	Research Area

HY-W108953

Myristoyl tetrapeptide-12	TGF-beta/Smad	Metabolic Disease
Myristoyl tetrapeptide-12 directly activates *SMAD2* and induces the linking of SMAD3 with DNA. Myristoyl tetrapeptide-12 is capable of stimulating hair growth, especially at the level of eyelashes .

Cat. No.	Product Name	Target	Research Area

HY-P99720

Luspatercept ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits *Smad2/3* signaling. Luspatercept can be used for the research of anemia .

HY-P99494

Carotuximab TRC105; DE-122	TGF-beta/Smad	Cancer
Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions .

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

Species:	Human (5) Mouse (3) Rat (1)
Tag:	His (7) SUMO (1) Tag Free (2) GST (3) Flag (1)
Source:	Sf9 insect cells (4) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P74540

	SMAD5 Protein, Mouse (sf9) Mothers against decapentaplegic homolog 5; Dwarfin-C; Smad 5	Mouse	Sf9 insect cells
	SMAD5 (dwarfin C, JV5-1, MAD5) is a receptor activated Smad (R-Smad) belonging to the dwarfin/SMAD family. SMAD5 protein is activated by TGF-β receptor type I and binds to SMAD4 to form a trimer active form. SMAD5 is involved in BMP signaling pathway, regulates osteogenesis and is related to embryonic development. SMAD5 can up-regulate Runx2 expression and target osteocalcin and alkaline phosphatase (ALP) to function. SMAD5 Protein, Mouse (sf9) has 464 amino acids expressed by sf9 insect cells with tag free.

HY-P74539

	SMAD5 Protein, Mouse (sf9, His-GST) Mothers against decapentaplegic homolog 5; Dwarfin-C; Smad 5	Mouse	Sf9 insect cells
	SMAD5 (dwarfin C, JV5-1, MAD5) is a receptor activated Smad (R-Smad) belonging to the dwarfin/SMAD family. SMAD5 protein is activated by TGF-β receptor type I and binds to SMAD4 to form a trimer active form. SMAD5 is involved in BMP signaling pathway, regulates osteogenesis and is related to embryonic development. SMAD5 can up-regulate Runx2 expression and target osteocalcin and alkaline phosphatase (ALP) to function. SMAD5 Protein, Mouse (sf9, His-GST) has 464 amino acids expressed by sf9 insect cells with N-terminal His- and GST-tag.

HY-P71323

	SMAD3 Protein, Human (Flag-His) 1 Publications Verification Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; Smad family member 3; Smad 3; Smad3; hSmad3; Smad3; MADH3	Human	E. coli
	The SMAD3 protein acts as a receptor-regulated SMAD (R-SMAD), transducing signals from TGF-β and activin type 1 receptor kinase. After being activated by antigen-presenting cells, SMAD3 binds to the TRE element in the gene promoter and forms a complex with SMAD4 to activate transcription. SMAD3 Protein, Human (Flag-His) is the recombinant human-derived SMAD3 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of SMAD3 Protein, Human (Flag-His) is 424 a.a., with molecular weight of 50-60 kDa.

HY-P71324

	SMAD4 Protein, Human (His) Mothers Against Decapentaplegic Homolog 4; MAD Homolog 4; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; Smad Family Member 4; Smad 4; Smad4; hSmad4; Smad4; DPC4; MADH4	Human	E. coli
	SMAD4 is a class of common mediator SMAD (Co-SMAD), which belongs to the dwarfin/SMAD family. It conducts cell signals through the SMAD4/TGF-β pathway and plays an important role in promoting bone development and tissue homeostasis. SMAD4 induces chondrogenesis of human bone marrow mesenchymal stem cells, and specifically targets stem cells to participate in self-renewal of hematopoietic stem cells. SMAD4 can also protect cell apoptosis and inhibit epithelial cell proliferation, showing antitumor effects. SMAD4 Protein, Human (His) has the 552 a.a. sequence (M1-D552), produced in E.coli with C-terminal 6*His-tag.

HY-P73636

	SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) Mothers against decapentaplegic homolog 3; mMad3; Smad3; Madh3	Rat	Sf9 insect cells
	The SMAD3 protein is an R-SMAD that acts as an intracellular signal transducer activated by TGF-β and activin type 1 receptor kinase. It binds TRE elements and regulates TGF-β target genes. SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is the recombinant rat-derived SMAD3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is 425 a.a., with molecular weight of ~75.9 kDa.

HY-P71536

	SMAD2 Protein, Human (His-SUMO) Drosophila, homolog of, MADR2; hMAD-2; HSmad2; JV18; JV18-1; JV181; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers against DPP homolog 2; OTTHUMP00000163489; Sma- and Mad-related protein 2 MAD; Smad 2; Smad family member 2; Smad2; Smad2_HUMAN	Human	E. coli
	SMAD2 protein, an R-SMAD, acts as a transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds TRE elements, regulating TGF-beta target genes. Forming a complex with SMAD4, it promotes transcription, positively regulating PDPK1 and showing potential tumor suppressor functions in colorectal carcinoma. SMAD2 interacts with various proteins, participating in signal transduction and transcriptional regulation. SMAD2 Protein, Human (His-SUMO) is the recombinant human-derived SMAD2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of SMAD2 Protein, Human (His-SUMO) is 466 a.a., with molecular weight of ~68.2 kDa.

HY-P73637

	SMAD2 Protein, Mouse (sf9, His-GST) Mothers against decapentaplegic homolog 2; MAD homolog 2; hMAD-2; Smad2; MADH2; MADR2	Mouse	Sf9 insect cells
	SMAD2 protein interacts with multiple partners, such as CREB-binding protein (CBP), EP300, SNON, and others. These interactions contribute to diverse cellular processes, including TGF-beta signaling and transcriptional regulation. SMAD2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived SMAD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SMAD2 Protein, Mouse (sf9, His-GST) is 466 a.a., with molecular weight of ~90 kDa.

HY-P701512

	SMURF2 Protein, Human (His) SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; Smad ubiquitination regulatory factor 2; Smad-specific E3 ubiquitin-protein ligase 2	Human	E. coli
	SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human (His) is the recombinant human-derived SMURF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SMURF2 Protein, Human (His) is 747 a.a., .

HY-P701513

	SMURF2 Protein, Human SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; Smad ubiquitination regulatory factor 2; Smad-specific E3 ubiquitin-protein ligase 2	Human	E. coli
	SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human is the recombinant human-derived SMURF2 protein, expressed by E. coli , with tag free. The total length of SMURF2 Protein, Human is 747 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-B0252S

Hydrochlorothiazid-d2

Hydrochlorothiazid-d₂ is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

HY-B0252S2

Hydrochlorothiazide-13C6

Hydrochlorothiazide- ¹³C₆ is the ¹³C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].

HY-116084S

Trimethylamine N-oxide-d9

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-B0252S1

Hydrochlorothiazid-13C,d2

Hydrochlorothiazid- ¹³C,d₂ is the ¹³C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P80324

Smad2 Antibody	WB, ICC, IHC-P, IP, FC	Human, Mouse, Rat
Smad2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Smad2. It can be used for WB,ICC,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80325

Smad3 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
Smad3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 58 kDa, targeting to Smad3. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80326

Smad4 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
Smad4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to Smad4. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80323

Smad1 Antibody	WB, ICC/IF, IHC-P	Human, Mouse
Smad1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Smad1. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80327

Smad5 Antibody	WB, ICC, IHC-P, FC	Human, Mouse
Smad5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Smad5. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80854

*Phospho-Smad3 (Ser423/425) Antibody* Smad3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; Smad family member 3; Smad 3; Smad3; hSmad3	WB, IHC-P, ICC/IF	Human, Mouse
Phospho-Smad3 (Ser423/425) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 48 kDa, targeting to Phospho-Smad3 (Ser423/425). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P80893

Smad2/3 Antibody Smad2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; Smad family member 2; Smad 2; Smad2; hSmad2	WB, ICC/IF, FC, IP, ChIP	Human, Mouse, Rat
Smad2/3 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 52 kDa, targeting to Smad2/3. It can be used for WB,ICC/IF,FC,IP,ChIP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80853

*Phospho-Smad2 (Ser250) Antibody* Smad2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; Smad family member 2; Smad 2; Smad2; hSmad2	WB	Human, Mouse, Rat, Hamster
Phospho-Smad2 (Ser250) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Phospho-Smad2 (Ser250). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P80852

*Phospho-Smad1 (Ser463/Ser465) Antibody* Smad1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; Smad family member 1; Smad 1; Smad1; hSmad1; Transforming growth factor-beta-signaling protein	WB, IP	Human, Rat
Phospho-Smad1 (Ser463/Ser465) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Phospho-Smad1 (Ser463/Ser465). It can be used for WB,IP assays with tag free, in the background of Human, Rat.

HY-P83093

*Phospho-Smad5 (Ser463/465) Antibody (YA2838)* DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad 5; hSmad5; JV5 1; JV5-1; MAD homolog 5; MAD mothers against decapentaplegic homolog 5; MAD; mothers against decapentaplegic homolog 5; MADH 5; MADH5; Mothers against decapentaplegic homolog 5; Mothers against DPP homolog 5; MusMLP; SMA and MAD related protein 5; Smad 5; Smad family member 5; Smad mothers against DPP homolog 5; Smad5; Smad5; Smad5_HUMAN.	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P81129

SMAD7 Antibody MAD (mothers against decapentaplegic Drosophila) homolog 7; MAD; Mad homolog 7; MAD mothers against decapentaplegic homolog 7; MADH 7; MADH 8; MADH8; Mothers Against Decapentaplegic Drosophila Homolog of 7; Mothers against decapentaplegic homolog 7; Mothers against decapentaplegic homolog 8; Mothers against DPP homolog 7; Mothers against DPP homolog 8; SMA- AND MAD-RELATED PROTEIN 7; Smad 7; Smad; Smad family member 7; Smad, mothers against DPP homolog 7 (Drosophila); Smad, mothers against DPP homolog 7; Smad7_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Pig, Cow)
SMAD7 Antibody is an unconjugated, approximately 46 kDa, rabbit-derived, anti-SMAD7 polyclonal antibody. SMAD7 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: pig, cow background without labeling.

HY-P83309

GARS Antibody (YA3054)

HMN5; CMT2D; DSMAV; GlyRS; Smad1
WB, IHC-P Human, Mouse, Rat

HY-P80477

*Phospho-Smad3 (Ser423/Ser425) Antibody*	WB, ICC/IF, IHC-P	Human, Mouse
Phospho-Smad3 (Ser423/Ser425) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to Phospho-Smad3(S423/S425). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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