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Results for "

Smo

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Smo (45) Apoptosis (4) Autophagy (1) Bacterial (1) c-Met/HGFR (2) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) Gli (2) Glucocorticoid Receptor (1) Hedgehog (11) iGluR (2) Isotope-Labeled Compounds (1) Organoid (1) Small Interfering RNA (siRNA) (3) TAM Receptor (2)
By Research Areas:	Cancer (44) Endocrinology (2) Infection (2) Inflammation/Immunology (2) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Smo

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150564

SMO-IN-2	Smo Hedgehog	Cancer
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-150567

SMO-IN-3	Smo Hedgehog	Cancer
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-147743

SMO-IN-1

Smo Cancer

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .
HY-153499

SMO-IN-4

Smo Cancer

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity .

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

SMO-IN-4	Smo	Cancer
SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity .

HY-RS13441

SMO Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMO Human Pre-designed siRNA Set A contains three designed siRNAs for SMO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMO Human Pre-designed siRNA Set A SMO Human Pre-designed siRNA Set A

HY-RS13442

Smo Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smo Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smo gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smo Mouse Pre-designed siRNA Set A Smo Mouse Pre-designed siRNA Set A

HY-RS13443

Smo Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smo Rat Pre-designed siRNA Set A contains three designed siRNAs for Smo gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smo Rat Pre-designed siRNA Set A Smo Rat Pre-designed siRNA Set A

HY-12848C

SAG dihydrochloride 15+ Cited Publications	Smo	Cancer
SAG dihydrochloride is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-145918

MRT-14	Smo	Cancer
MRT-14 is a potent antagonist of *Smo. Smo* is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling .

HY-131016

IHR-Cy3

Smo Cancer

IHR-Cy3 is a potent fluorescent Smo antagonist with an IC₅₀ of 100 nM .

IHR-Cy3	Smo	Cancer
IHR-Cy3 is a potent fluorescent *Smo* antagonist with an IC₅₀ of 100 nM .

HY-16391A

Glasdegib maleate PF-04449913 maleate	Smo	Cancer
Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable smoothened inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC₅₀value of 4 nM .

HY-18287A

MRT-83 hydrochloride	Smo	Cancer
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .

HY-13459

PF-5274857	Smo	Cancer
PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of *Smo, with an IC₅₀* of 5.8 nM and K_i of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-13459A

PF-5274857 hydrochloride	Smo	Cancer
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of *Smo, with an IC₅₀* of 5.8 nM and K_i of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway .

HY-108508

SMANT hydrochloride	Smo Hedgehog	Cancer
SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo .

HY-19642A

Glesatinib hydrochloride 2 Publications Verification MGCD265 hydrochloride	TAM Receptor c-Met/HGFR	Cancer
Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent *MET/SMO* dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-19642

Glesatinib MGCD265	TAM Receptor c-Met/HGFR	Cancer
Glesatinib (MGCD265) is an orally active, potent *MET/SMO* dual inhibitor. Glesatinib, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-16582A

Sonidegib 5 Publications Verification EriSmodegib; LDE225; NVP-LDE225	Smo	Cancer
Sonidegib (Erismodegib) is a potent and selective *Smo* antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-12317

GSA-10	Smo Hedgehog	Cancer
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .

HY-16582

Sonidegib diphosphate 5 Publications Verification EriSmodegib diphosphate; LDE225 diphosphate; NVP-LDE225 diphosphate	Smo	Cancer
Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective *Smo* antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-16582AS

Sonidegib-d4 EriSmodegib-d₄; LDE225-d₄; NVP-LDE225-d₄	Isotope-Labeled Compounds	Others
Sonidegib-d4 is a isotope of Sonidegib. Sonidegib is a potent and selective Smo antagonist with IC₅₀ of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively .

HY-13809

BMS-833923 XL-139	Smo Apoptosis	Cancer
BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC₅₀ of 21 nM .

HY-12848

SAG 15+ Cited Publications	Smo	Cancer
SAG is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848B

SAG hydrochloride 15+ Cited Publications	Smo	Cancer
SAG hydrochloride is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-15108

Purmorphamine

10+ Cited Publications

Organoid Smo Autophagy Neurological Disease Cancer

Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM.
HY-110240

IHR-1

Smo Others

IHR-1 is a cell membrane impermeable Smo antagonist .

Purmorphamine 10+ Cited Publications	Organoid Smo Autophagy	Neurological Disease Cancer
Purmorphamine is a *smoothened/Smo* receptor agonist with an EC₅₀** of 1 μM.

IHR-1	Smo	Others
IHR-1 is a cell membrane impermeable *Smo* antagonist .

HY-117407

ALLO-2	Smo	Cancer
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM .

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent *Smoothened (Smo) receptor* agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-15412

HhAntag

Smo Cancer

HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway .

HhAntag	Smo	Cancer
HhAntag is a specific, potent and orally active small molecule *SMO* antagonist of the Hh pathway .

HY-108507

MRT-10	Smo	Cancer
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC₅₀ of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .

HY-16587

Saridegib

IPI-926; Patidegib
Smo Cancer

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened *(Smo)*, a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-17024

Cyclopamine Maximum Cited Publications 33 Publications Verification 11-Deoxojervine	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective *Smo* inhibitor.

HY-18636

LEQ506

NVP-LEQ506
Smo Cancer

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.
HY-100515

Robotnikinin

3 Publications Verification

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo .
HY-147744

AZD7254

Smo Cancer

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .
HY-18287

MRT-83

Smo Cancer

MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

LEQ506 NVP-LEQ506	Smo	Cancer
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

Robotnikinin 3 Publications Verification
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo .

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

MRT-83	Smo	Cancer
MRT-83 is a potent antagonist of *Smo, with an IC₅₀* in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks *Smo* (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity .

HY-16391

Glasdegib 4 Publications Verification PF-04449913	Smo	Cancer
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human *SMO* (amino acids 181-787) with an IC₅₀ of 4 nM .

HY-12848S

SAG-d3

Smo Cancer

SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

SAG-d3	Smo	Cancer
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

HY-120499

AZD8542	Hedgehog Smo	Cancer
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a? Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .

HY-B0603

Fluticasone	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a *Smo* agonist with an IC₅₀ value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-N0247

Saikosaponin B1	Smo	Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting *SMO* .

HY-148440

RL-0070933	Hedgehog Smo	Cancer
RL-0070933 is a potent smo cilial modulator with an EC₅₀ value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway .

HY-15108G

Purmorphamine	Smo	Neurological Disease Cancer
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a *smoothened/Smo* receptor** agonist with an EC₅₀ of 1 μM .

HY-148828

LSP-GR3	iGluR
LSP-GR3 is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

HY-148828A

LSP-GR3 sodium	iGluR	Neurological Disease
LSP-GR3 sodium is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

HY-15483

DY131 2 Publications Verification GSK 9089	Estrogen Receptor/ERR Smo	Endocrinology Cancer
DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ . DY131 also inhibits *Smo* signaling .

HY-100224

SANT-1 2 Publications Verification
SANT-1, a potent *Smo* antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-12316

20(S)-Hydroxycholesterol 1 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cancer
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-162372

Hedgehog IN-6	Hedgehog Smo	Cancer
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .

Cat. No.	Product Name	Category	Target	Chemical Structure