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Results for "

Smoothened

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Smo (32) Apoptosis (4) Autophagy (1) Endogenous Metabolite (2) Gli (1) Hedgehog (12) Organoid (1)
By Research Areas:	Cancer (33) Inflammation/Immunology (1) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Smo

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108508

SMANT hydrochloride	Smo Hedgehog	Cancer
SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo .

HY-18287A

MRT-83 hydrochloride	Smo	Cancer
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .

HY-16391A

Glasdegib maleate PF-04449913 maleate	Smo	Cancer
Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable *smoothened* inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC₅₀value of 4 nM .

HY-120499

AZD8542	Hedgehog Smo	Cancer
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a? Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .

HY-162372

Hedgehog IN-6	Hedgehog Smo	Cancer
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity .

HY-13242

Taladegib

1 Publications Verification

LY2940680
Smo Cancer

Taladegib (LY2940680) is an antagonist of the smoothened receptor.
HY-15108

Purmorphamine

10+ Cited Publications

Organoid Smo Autophagy Neurological Disease Cancer

Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM.
HY-100535

KAAD-Cyclopamine

Cyclopamine-KAAD

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist .
HY-16587

Saridegib

IPI-926; Patidegib
Smo Cancer

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
HY-18636

LEQ506

NVP-LEQ506
Smo Cancer

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.
HY-147744

AZD7254

Smo Cancer

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .
HY-147743

SMO-IN-1

Smo Cancer

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .
HY-153499

SMO-IN-4

Smo Cancer

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity .

Taladegib 1 Publications Verification LY2940680	Smo	Cancer
Taladegib (LY2940680) is an antagonist of the *smoothened* receptor.

Purmorphamine 10+ Cited Publications	Organoid Smo Autophagy	Neurological Disease Cancer
Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM.

KAAD-Cyclopamine Cyclopamine-KAAD
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a *smoothened* antagonist .

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

LEQ506 NVP-LEQ506	Smo	Cancer
LEQ506 is a second-generation inhibitor of *smoothened* (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively.

AZD7254	Smo	Cancer
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 1.0 nM against sonic Hh protein (shh) .

SMO-IN-1	Smo	Cancer
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh) .

SMO-IN-4	Smo	Cancer
SMO-IN-4 (Compound 24) is a potent and orally active *smoothened* antagonist (IC₅₀: 24 nM). SMO-IN-4 has antitumor activity .

HY-16391

Glasdegib 4 Publications Verification PF-04449913	Smo	Cancer
Glasdegib (PF-04449913) is a potent and orally bioavailable *smoothened* inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC₅₀ of 4 nM .

HY-12848S

SAG-d3

Smo Cancer

SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

SAG-d3	Smo	Cancer
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

HY-13809

BMS-833923 XL-139	Smo Apoptosis	Cancer
BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC₅₀ of 21 nM .

HY-148440

RL-0070933	Hedgehog Smo	Cancer
RL-0070933 is a potent smo cilial modulator with an EC₅₀ value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway .

HY-12848

SAG Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848B

SAG hydrochloride Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848C

SAG dihydrochloride Maximum Cited Publications 18 Publications Verification	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-15108G

Purmorphamine	Smo	Neurological Disease Cancer
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM .

HY-117407

ALLO-2	Smo	Cancer
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM .

HY-150564

SMO-IN-2	Smo Hedgehog	Cancer
SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-150567

SMO-IN-3	Smo Hedgehog	Cancer
SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC₅₀ value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity .

HY-12316

20(S)-Hydroxycholesterol 1 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cancer
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the *oncoprotein smoothened* (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀** of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-145387

MRT-81	Smo	Cancer
MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC₅₀ value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer .

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-18366A

RU-SKI 43 hydrochloride	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-108507

MRT-10	Smo	Cancer
MRT-10 is a seven-transmembrane *receptor smoothened* (Smo) antagonist with an IC₅₀** of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .

HY-113965

CUR61414 1 Publications Verification	Hedgehog Smo Apoptosis	Inflammation/Immunology
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC₅₀ =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a K_i value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells .

HY-100036

MK-4101	Smo Apoptosis Hedgehog	Cancer
MK-4101 is a Smoothened (SMO) antagonist (IC₅₀ of 1.1 µM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC₅₀ of 1.5 µM for mouse cells; IC₅₀ of 1 µM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 20α-Hydroxycholesterol (Standard)	Smo Endogenous Metabolite	Cancer
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the *oncoprotein smoothened* (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀** of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-12317

GSA-10	Smo Hedgehog	Cancer
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .

Purmorphamine (GMP)	Fluorescent Dye
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM .

Purmorphamine (GMP)	Biochemical Assay Reagents
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12316

20(S)-Hydroxycholesterol 1 Publications Verification 20α-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the *oncoprotein smoothened* (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀** of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 20α-Hydroxycholesterol (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the *oncoprotein smoothened* (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀** of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

Cat. No.	Product Name	Chemical Structure

HY-12848S

SAG-d3

SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

SAG-d3
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

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Smoothened

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products