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Results for "

Sotorasib

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114277
    Sotorasib
    40+ Cited Publications

    AMG-510

    		 Ras Cancer
    Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors .
    <em>Sotorasib</em>
  • HY-114277A
    Sotorasib racemate

    AMG-510 racemate

    		 Ras p38 MAPK Cancer
    Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research .
    <em>Sotorasib</em> racemate
  • HY-114277B
    Sotorasib isomer

    AMG-510 isomer

    		 Others Others
    Sotorasib (AMG-510) isomer is the less active isomer of Sotorasib (AMG-510). AMG-510 is a potent KRAS G12C covalent inhibitor.
    <em>Sotorasib</em> isomer
  • HY-114277S
    Sotorasib-d7

    AMG-510-d7

    		 Ras Cancer
    Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib (HY-114277). Sotorasib is an orally active covalent inhibitor of KRAS G12C. Sotorasib can lead to the regression of KRAS G12C tumors .
    <em>Sotorasib</em>-d7
  • HY-161234
    KRAS ligand 3

    		Others Cancer
    KRAS ligand 3 (compound 1) is BTX-6654 target-binding ligand that can bind KRAS inhibitor and diaplay synergistic tumor growth inhibiton .
    KRAS ligand 3

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