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Results for "

Sperm Inhibitors

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Peptides

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17519
    Novaluron

    		Insecticide Infection
    Novaluron is a chemical with insecticide properties, an insect growth regulator, and has adverse effects on mouse sperm .
    Novaluron
  • HY-137814
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride

    NPGB hydrochloride

    		 Ser/Thr Protease Endocrinology
    4-Nitrophenyl 4-guanidinobenzoate (NPGB) hydrochloride is a potent sperm acrosin inhibitor, and also a trypsin substrate .
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • HY-104013
    Aminopurvalanol A
    1 Publications Verification

    		 CDK Apoptosis Cancer
    Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization .
    Aminopurvalanol A
  • HY-W040129
    Chromomycin A3
    1 Publications Verification

    		 Bacterial Fungal Apoptosis Antibiotic Infection Cancer
    Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg 2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor .
    Chromomycin A3
  • HY-125913
    Benzamidine

    		Ser/Thr Protease Infection
    Benzamidine is a reversible competitive trypsin inhibitor with a Ki of 19 μM . Benzamidine shows inhibitory activity against homogeneous boar sperm acrosin with a Ki of 4 μM .
    Benzamidine
  • HY-135438
    Mollugogenol A

    		Fungal Infection
    Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity .
    Mollugogenol A
  • HY-126476
    Justicisaponin I

    		Others Others
    Justicisaponin I can be used as an anti-fertility agent. Justicisaponin I stabilizes the acrosome membrane of sperm, and inhibits the release of acid hydrolase and sperm proteins .
    Justicisaponin I
  • HY-119793
    Tolnidamine

    		Others Others
    Tolnidamine is an orally active sperm production inhibitor .
    Tolnidamine
  • HY-164911
    VU0546110

    		Potassium Channel Endocrinology
    VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K + currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential .
    VU0546110
  • HY-164032
    Dimethandrolone undecanoate

    7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate

    		 GnRH Receptor Endocrinology
    Dimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives .
    Dimethandrolone undecanoate
  • HY-N13214
    Maca Extract (10:1)

    		Others Metabolic Disease
    Maca Extract is a maca extract. Maca Extract has the potential to improve fertility and sexual function, and can improve non-obstructive azoospermia. The polysaccharide part is its active ingredient. Maca Extract can alleviate seminiferous tubule vacuolation and testicular lesions. It improves sperm quantity and quality by promoting the recovery of seminiferous epithelium, inhibiting stromal cell proliferation, and increasing serum testosterone levels. .
    Maca Extract (10:1)
  • HY-P10817
    Corza6

    		Proton Pump Reactive Oxygen Species Metabolic Disease
    Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .
    Corza6

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