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Results for "

SphK2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Autophagy (3) LPL Receptor (3) Small Interfering RNA (siRNA) (3) SphK (14)
By Research Areas:	Cancer (13) Cardiovascular Disease (5) Inflammation/Immunology (6) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS13667

SPHK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SPHK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPHK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPHK2 Human Pre-designed siRNA Set A SPHK2 Human Pre-designed siRNA Set A

HY-RS13668

Sphk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sphk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk2 Mouse Pre-designed siRNA Set A Sphk2 Mouse Pre-designed siRNA Set A

HY-RS13669

Sphk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sphk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk2 Rat Pre-designed siRNA Set A Sphk2 Rat Pre-designed siRNA Set A

HY-151350

SphK2-IN-1	SphK	Cardiovascular Disease Inflammation/Immunology Cancer
SphK2-IN-1 is a *SphK2* inhibitor (IC₅₀: 0.359 μM). SphK2-IN-1 can be used in the research of cancer, inflammation, neurological and cardiovascular disorders .

HY-151351

SphK2-IN-2

SphK Cancer

SphK2-IN-2 (21g) is a potent and selective SphK2 inhibitor with an IC₅₀ value of 0.23 μM .

SphK2-IN-2	SphK	Cancer
SphK2-IN-2 (21g) is a potent and selective *SphK2* inhibitor with an IC₅₀ value of 0.23 μM .

HY-147282

Amgen-23	SphK	Cancer
Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC₅₀ values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer .

HY-15779

K145	SphK Apoptosis	Cancer
K145 is a selective, substrate-competitive and orally active *SphK2* inhibitor with an IC₅₀ of 4.3 µM and a K_i of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity .

HY-15779A

K145 hydrochloride 5+ Cited Publications	SphK Apoptosis	Cancer
K145 hydrochloride is a selective, substrate-competitive and orally active *SphK2* inhibitor with an IC₅₀ of 4.3 µM and a K_i of 6.4 µM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity .

HY-W019781

Biotinylated sphingosine Biotinyl-Sph	SphK	Metabolic Disease
Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 .

HY-148707

SphK1&2-IN-1

SphK Cardiovascular Disease Inflammation/Immunology Cancer

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability ^[2].

SphK1&2-IN-1	SphK	Cardiovascular Disease Inflammation/Immunology Cancer
SphK1&2-IN-1 is a *SphK* inhibitor targeting to *SphK1* and *SphK2. SphK*1&2-IN-1 has thermal stability ^[2].

HY-19794

MP-A08	SphK	Cancer
MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.

HY-120268A

SLM6031434 hydrochloride	SphK	Inflammation/Immunology Cancer
SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with K_is of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research ^[2].

HY-150513

SLP9101555	SphK	Cancer
SLP9101555 (compound 14c) is a potent and selective *SphK2* (sphingosine kinase 2) inhibitor (K_i=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels .

HY-150615

SphK1-IN-2	SphK Apoptosis	Cancer
SphK1-IN-2 is a potent, selective *SphK1* inhibitor with IC₅₀ values of 19.81 nM and ＞10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research .

HY-15425

PF-543 Maximum Cited Publications 7 Publications Verification Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy ^[2] .

HY-15425B

PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy ^[2] .

HY-15425A

PF-543 Citrate Maximum Cited Publications 7 Publications Verification Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy ^[2] .

HY-12892

SKI-178
SKI-178 is a potent sphingosine kinase-1 (SphK1) and *SphK2* inhibitor. SKI-178 is cytotoxic at IC₅₀ concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines ^[2].

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SphK2

Inhibitors & Agonists