Sphingomyelin

By Targets:	Antibiotic (1) Endogenous Metabolite (6) Fluorescent Dye (3) HCV (1) Isotope-Labeled Compounds (1) Liposome (1) LPL Receptor (2) Phospholipase (4)
By Research Areas:	Cancer (2) Endocrinology (2) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113498

*Sphingomyelin*	Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease .

HY-D1584

C12 NBD Sphingomyelin	Phospholipase	Others
C12 NBD sphingomyelin is an active derivative of sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .

HY-P2936

Sphingomyelin phosphodiesterase, Streptomyces sp.	Phospholipase	Metabolic Disease
Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .

HY-112016A

Sphingomyelin C20:2 SM C20:2	Others	Neurological Disease
Sphingomyelin C20:2 (SM C20:2) is a sphingomyelin biomarker metabolite. Sphingomyelin C20:2 can be used in Alzheimer's disease (AD) research .

HY-141629

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0	Liposome Endogenous Metabolite	Others
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-D1574

C6 NBD Sphingomyelin	Fluorescent Dye	Others
C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane .

HY-141629S

N-Palmitoyl-D-sphingomyelin-d31

Isotope-Labeled Compounds Endogenous Metabolite Others

N-Palmitoyl-D-sphingomyelin-d₃₁ is deuterium labeled N-Palmitoyl-D-sphingomyelin.

*N-Palmitoyl-D-sphingomyelin-d31*	Isotope-Labeled Compounds Endogenous Metabolite	Others
N-Palmitoyl-D-sphingomyelin-d₃₁ is deuterium labeled N-Palmitoyl-D-sphingomyelin.

HY-145520

(±)-2'-hydroxy Ceramide (d18:0/18:0) (±)-2'-hydroxy Cer(d18:0/18:0)	Endogenous Metabolite	Neurological Disease
(±)-2'-hydroxy Ceramide (d18:0/18:0) is a sphingomyelin that can be isolated from mammalian platelets stimulation by ADP .

HY-148388

N-Stearoylsphingomyelin N-Stearoyl-D-Sphingomyelin	Phospholipase	Cancer
N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) is a sphingolipid, which can inhibit Phospholipase Cδ1 (PLCδ1) .

HY-102041

SMS2-IN-1	Others	Inflammation/Immunology
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC₅₀ of 6.5 nM and a K_d of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC₅₀ of 1000 nM) .

HY-N8518

Malabaricone C

Others Metabolic Disease

Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC₅₀s of 3 and 1.5 μM for SMS 1 and 2, respectively .
HY-114307

Ly93

1 Publications Verification

Others Inflammation/Immunology

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC₅₀ of 91 nM .
HY-150559

SMS2-IN-3

Others Infection Others Cancer

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels .

Malabaricone C	Others	Metabolic Disease
Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC₅₀s of 3 and 1.5 μM for SMS 1 and 2, respectively .

Ly93 1 Publications Verification	Others	Inflammation/Immunology
Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC₅₀ of 91 nM .

SMS2-IN-3	Others	Infection Others Cancer
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels .

HY-Y1242

Choline hydroxide, 44 wt.% in water
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .

HY-112713

SMS2-IN-2	Others	Inflammation/Immunology
SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC₅₀s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity .

HY-135642

SMS1-IN-1	Others	Inflammation/Immunology
SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC₅₀ value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dye	Others
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

HY-155111

nSMase2-IN-1	Phospholipase	Neurological Disease
nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC₅₀ value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research .

HY-100353

C12-Ceramide N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine
C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease .

HY-108496

Sphingosine-1-phosphate 5 Publications Verification S1P	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-W356116

C6 NBD Ceramide Nbd-ceramide	Fluorescent Dye	Others
C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism .

HY-N6798

Myriocin 4 Publications Verification Thermozymocidin; ISP-I	HCV Antibiotic	Infection
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC₅₀ of 3.5 µg/mL for inhibiting HCV infection .

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d₇	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

Cat. No.	Product Name	Type

HY-D1584

C12 NBD Sphingomyelin	Fluorescent Dyes/Probes
C12 NBD sphingomyelin is an active derivative of sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .

HY-D1574

C6 NBD Sphingomyelin	Fluorescent Dyes/Probes
C6 NBD Sphingomyelin is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). Chlamydia trachomatis acquires C6 NBD Sphingomyelin endogenously synthesizes from C6-NBD-ceramide and transportes to the chlamydial inclusion. C6 NBD Sphingomyelin can incorporate into the plasma membrane .

HY-W356116

C6 NBD Ceramide Nbd-ceramide	Dyes
C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism .

C6 NBD Ceramide

Nbd-ceramide

Dyes

C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dyes/Probes
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

Cat. No.	Product Name	Type

HY-141629

N-Palmitoyl-D-sphingomyelin

Sphingomyelin 16:0
Drug Delivery

N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0	Drug Delivery
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113498

*Sphingomyelin*	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease .

HY-N8518

Malabaricone C	Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Disease Research Fields	Others
Malabaricone C is a natural sphingomyelin synthase (SMS) inhibitor with IC₅₀s of 3 and 1.5 μM for SMS 1 and 2, respectively .

HY-108496

Sphingosine-1-phosphate 5 Publications Verification S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids .

HY-141629

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Liposome Endogenous Metabolite
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-145520

(±)-2'-hydroxy Ceramide (d18:0/18:0) (±)-2'-hydroxy Cer(d18:0/18:0)	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)-2'-hydroxy Ceramide (d18:0/18:0) is a sphingomyelin that can be isolated from mammalian platelets stimulation by ADP .

HY-N6798

Myriocin 4 Publications Verification Thermozymocidin; ISP-I	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	HCV Antibiotic
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC₅₀ of 3.5 µg/mL for inhibiting HCV infection .

Species:	Human (4) Mouse (1)
Tag:	His (4) Fc (1)
Source:	HEK293 (1) E. coli Cell-free (2) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73632

	Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthase 2; SGMS2; SMS2	Human	HEK293
	The sphingomyelin synthase 2 (SGMS2) protein plays a crucial role in plasma membrane sphingomyelin synthesis. It catalyzes the reversible transfer of the phosphocholine moiety in sphingomyelin biosynthesis to form ceramide phosphocholine. Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is the recombinant human-derived Sphingomyelin Synthase 2/SGMS2 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is 79 a.a., with molecular weight of ~35.7 kDa.

HY-P76710

	SMPD1 Protein, Human (sf9, His) Sphingomyelin phosphodiesterase; Acid Sphingomyelinase; ASMase; Smpd1; Asm	Human	Sf9 insect cells
	SMPD1 protein converts sphingomyelin to ceramide in lysosomes and has phospholipase C activity. SMPD1 Protein, Human (sf9, His) is the recombinant human-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SMPD1 Protein, Human (sf9, His) is 628 a.a., with molecular weight of ~66.3 KDa.

HY-P76134

	SMPD1 Protein, Mouse (sf9, His) Sphingomyelin phosphodiesterase; Acid Sphingomyelinase; ASMase; Smpd1; Asm	Mouse	Sf9 insect cells
	The SMPD1 protein converts sphingomyelin to ceramide through two enzymatic forms, one targeted to endolysosomes and the other released extracellularly. Lysosomal exocytosis becomes a significant source of the secretory form during stress responses. SMPD1 also exports cholesterol from intraendolysosomal membranes and exhibits phospholipase C activities. Its role in stress-induced apoptosis modulation is mediated through ceramide production. SMPD1 Protein, Mouse (sf9, His) is the recombinant mouse-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SMPD1 Protein, Mouse (sf9, His) is 626 a.a., with molecular weight of ~63 KDa.

HY-P702447

	SMPD2 Protein, Human (Cell-Free, His) Sphingomyelin phosphodiesterase 2; Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral Sphingomyelinase; N-SMase; nSMase; nSMase1	Human	E. coli Cell-free
	In vitro experiments have demonstrated that the sphingomyelin phosphodiesterase 2 (SMPD2) protein plays a key role in catalyzing the hydrolysis of sphingomyelin, leading to the formation of ceramide and phosphocholine. Furthermore, SMPD2 exhibits its enzymatic activity by hydrolyzing 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (hemolytic platelet-activating factor) in vivo. SMPD2 Protein, Human (Cell-Free, His) is the recombinant human-derived SMPD2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SMPD2 Protein, Human (Cell-Free, His) is 423 a.a., with molecular weight of 49.1 kDa.

HY-P702433

	SGMS1 Protein, Human (Cell-Free, His) Phosphatidylcholine:ceramide cholinephosphotransferase 1; Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23	Human	E. coli Cell-free
	The SGMS1 protein is a key sphingomyelin synthase located in the Golgi apparatus and promotes sphingomyelin biosynthesis by transferring the phosphocholine moiety. This reversible reaction involves the conversion of phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol. SGMS1 Protein, Human (Cell-Free, His) is the recombinant human-derived SGMS1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SGMS1 Protein, Human (Cell-Free, His) is 413 a.a., with molecular weight of 51.4 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-141629S

N-Palmitoyl-D-sphingomyelin-d31

N-Palmitoyl-D-sphingomyelin-d₃₁ is deuterium labeled N-Palmitoyl-D-sphingomyelin.

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

Cat. No.	Product Name		Classification

HY-129084

Propargylcholine bromide		Alkynes
Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells . Propargylcholine (bromide) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry