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Squalene

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (7) Apoptosis (1) Bacterial (5) Farnesyl Transferase (3) Ferroptosis (1) Fungal (9) HCV (2) Isotope-Labeled Compounds (5) Parasite (1) PI3K (1) PTEN (1)
By Research Areas:	Cancer (4) Infection (11) Metabolic Disease (13)

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1214

*Squalene* Super Squalene; trans-Squalene; AddaVax
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N1214S

Squalene-d6 Super Squalene-d₆; trans-Squalene-d₆; AddaVax-d₆	Isotope-Labeled Compounds	Others
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-149405

Squalene synthase-IN-1	Others	Metabolic Disease
Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity .

HY-163452

Squalene synthase-IN-2	Others	Metabolic Disease
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC₅₀ values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Apoptosis	Cancer
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-W015635

Diallyl disulfide	Others	Cancer
Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC₅₀ of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities .

HY-103087

FIN56 5+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-N9777

Procyanidin B-5 3,3'-di-O-gallate	Others	Metabolic Disease
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

HY-B0348

Liranaftate Piritetrate; M-732	Fungal	Infection
Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation .

HY-100313A

YM-53601 2 Publications Verification	Farnesyl Transferase HCV	Infection Metabolic Disease
YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-N7113

Squalane	Others	Cancer
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-100313

YM-53601 free base	Farnesyl Transferase HCV	Metabolic Disease
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-160093

SQLE-IN-1	PTEN Akt PI3K	Metabolic Disease
SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of PTEN and inhibits PI3K and AKT .

HY-17395

Terbinafine hydrochloride 5+ Cited Publications TDT 067 hydrochloride	Fungal Bacterial Antibiotic	Infection
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17395A

Terbinafine 5+ Cited Publications TDT 067	Fungal Bacterial Antibiotic	Infection
Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17395B

Terbinafine lactate TDT 067 lactate	Antibiotic Fungal Bacterial	Infection
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100299

RPR107393 free base	Farnesyl Transferase	Metabolic Disease
RPR107393 free base is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC₅₀ of 0.8 nM.

HY-100303A

FR194738 2 Publications Verification	Others	Metabolic Disease
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-100303

FR194738 free base 2 Publications Verification	Others	Metabolic Disease
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-116290

Zaragozic acid A

Squalestatin S1
Others Others

Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .

Zaragozic acid A Squalestatin S1	Others	Others
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .

HY-16274

Lapaquistat acetate TAK-475	Others	Metabolic Disease
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .

HY-17396

Butenafine Hydrochloride 1 Publications Verification KP363 Hydrochloride	Fungal Antibiotic	Infection
Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-N3955

Alnusenone Glutinone; Glutinone	Others	Others
Alnusenone (Glutinone) is a stabilised intermediate int he biogenesis of friedelin (XV) from squalene. Alnusenone is the major natural compound in fractions .

HY-135625

BPH-1218	Parasite	Infection
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC₅₀ of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent .

HY-17396S

Butenafine-13C,d3 hydrochloride KP363-¹³C,d₃ hydrochloride	Isotope-Labeled Compounds Fungal Antibiotic	Infection
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-N7113S

Squalane-d62	Isotope-Labeled Compounds	Cancer
Squalane-d₆₂ is the deuterium labeled Squalane[1]. Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities[2].

HY-16343C

NB-598 Maleate Maximum Cited Publications 11 Publications Verification	Others	Metabolic Disease
NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16343

NB-598 Maximum Cited Publications 11 Publications Verification	Others	Metabolic Disease
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16343A

NB-598 hydrochloride	Others	Metabolic Disease
NB-598 hydrochloride is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114518

Butenafine KP363	Fungal	Infection
Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as tinea pedis, tinea cruris, tinea versicolor .

HY-17395S

Terbinafine-d3 hydrochloride TDT 067-d₃ hydrochloride	Isotope-Labeled Compounds Fungal Bacterial Antibiotic	Infection
Terbinafine-d₃ (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

HY-17395AS

Terbinafine-d7 TDT 067-d₇	Isotope-Labeled Compounds Fungal Bacterial Antibiotic	Infection
Terbinafine-d₇ is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015635

Diallyl disulfide	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Cancer	Others
Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC₅₀ of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities .

HY-N7113

Squalane	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Cancer	Others
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Structural Classification Natural Products Animals Source classification	Apoptosis
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-N9777

Procyanidin B-5 3,3'-di-O-gallate	Structural Classification Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants	Others
Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC₅₀ of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity .

HY-100313

YM-53601 free base	Structural Classification Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-116290

Zaragozic acid A Squalestatin S1	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Others
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .

HY-N3955

Alnusenone Glutinone; Glutinone	Triterpenes Structural Classification Terpenoids Source classification Polyporaceae Plants	Others
Alnusenone (Glutinone) is a stabilised intermediate int he biogenesis of friedelin (XV) from squalene. Alnusenone is the major natural compound in fractions .

	FDFT1 Protein, Human (His) DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; SQS; Squalene synthase; Squalene synthetase; SS	Human	E. coli
	FDFT1 is a key enzyme in cellular metabolism responsible for coordinating the condensation of two farnesyl pyrophosphate (FPP) molecules, a key step in sterol biosynthesis. The process proceeds in two distinct steps: First, two FPP molecules react to form the stable squalene diphosphate intermediate (PSQPP), releasing protons and inorganic diphosphate. FDFT1 Protein, Human (His) is the recombinant human-derived FDFT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FDFT1 Protein, Human (His) is 416 a.a., with molecular weight of ~52 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-N1214S

Squalene-d6
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-N7113S

Squalane-d62
Squalane-d₆₂ is the deuterium labeled Squalane[1]. Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities[2].

HY-17395S

Terbinafine-d3 hydrochloride

Terbinafine-d₃ (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

HY-17396S

Butenafine-13C,d3 hydrochloride
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-17395AS

Terbinafine-d7
Terbinafine-d₇ is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].

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Squalene

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products