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Results for "

TG2

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Inhibitory Antibodies

2

Recombinant Proteins

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Cat. No. Compare Product Name Species Source
  • HY-P78361
    TGM2/Transglutaminase 2 Protein, Mouse (His)

    Heart G alpha(h); TGM2; tTG; tTGase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase II; Transglutaminase-2; TG2; G-ALPHA-h; GNAH; HEL-S-45; C polypeptide; TGase-2; TGase-H; TGCGNAH

    		 Mouse E. coli
    TGM2/Transglutaminase 2 protein, a calcium-dependent acyltransferase, catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, leading to the cross-linking or amination of proteins. Involved in diverse biological processes such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification, and apoptosis, TGM2 acts as a protein-glutamine gamma-glutamyltransferase. It mediates the cross-linking of proteins, including ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1, and WDR54. The protein cross-linking activity is inhibited under physiological conditions by GTP, and this inhibition is relieved by Ca(2+) in response to various stresses. In addition to its role in apoptosis by promoting cytoskeletal protein cross-linking and mediating the formation of extracellular matrix scaffolds, TGM2 can use monoamine substrates to catalyze diverse protein post-translational modifications. It plays a crucial role in chromatin organization by mediating serotonylation and dopaminylation of histone H3, contributing to neurotransmission-independent functions in ventral tegmental area (VTA) neurons. Furthermore, TGM2 acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity, highlighting its involvement in signaling pathways beyond its acyltransferase activity. TGM2/Transglutaminase 2 Protein, Mouse (His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by E. coli , with N-His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (His) is 685 a.a., with molecular weight of ~78.2 kDa.
  • HY-P76114
    TGM2/Transglutaminase 2 Protein, Human (sf9, His)

    Protein-glutamine gamma-glutamyltransferase 2; Transglutaminase C; TGase-2

    		 Human Sf9 insect cells
    In summary, TGM2 is a multifunctional enzyme that plays crucial roles in various cellular processes. It acts as a protein-glutamine gamma-glutamyl transferase, mediating the cross-linking of proteins involved in cellular functions. TGM2/Transglutaminase 2 Protein, Human (sf9, His) is the recombinant human-derived TGM2/Transglutaminase 2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Human (sf9, His) is 687 a.a., with molecular weight of ~80 kDa.

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