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THZ-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-80013
    THZ1
    Maximum Cited Publications
    73 Publications Verification

    		 CDK Cancer
    THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression [1] .
    <em>THZ1</em>
  • HY-80013A
    THZ1 Hydrochloride
    Maximum Cited Publications
    73 Publications Verification

    		 CDK Cancer
    THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression [1] .
    <em>THZ1</em> Hydrochloride
  • HY-19988
    THZ1-R
    3 Publications Verification

    		 CDK Cancer
    THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.
    <em>THZ1</em>-R
  • HY-128867
    bio-THZ1

    		CDK Cancer
    bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM [1].
    bio-<em>THZ1</em>
  • HY-80013B
    (E/Z)-THZ1 dihydrochloride

    		CDK Cancer
    (E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect [1] .
    (E/Z)-<em>THZ1</em> dihydrochloride
  • HY-116871
    YKL-1-116

    		CDK Cancer
    YKL-1-116 is a selective and covalent inhibitor of Cdk7. YKL-1-116 does not target Cdk9, Cdk12, or Cdk13. YKL-1-116 is more potent than THZ1 (HY-80013) toward both Cdk7 WT and Cdk7 as, although Cdk7 as is relatively resistant to this compound as well [1].
    YKL-<em>1</em>-116

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