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Isoforms Recommended:	TLR3

Results for "

TLR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (4) ATM/ATR (1) Bacterial (1) Bcl-2 Family (1) HSP (1) Interleukin Related (1) Nucleoside Antimetabolite/Analog (1) Phosphatase (1) PKD (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (19)
By Research Areas:	Cancer (7) Infection (5) Inflammation/Immunology (16) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108473

CU-CPT 4a 1 Publications Verification TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .

HY-150746

ODN 24991	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24991, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a *TLR3, TLR7* and *TLR9* (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 24991 disrupts TLR3-, TLR7- and TLR9-mediated immune cell immune responses. ODN 24991 sequence: 5'-C-C-T-G-G-C-c7rGm-G-G-G-3' .

HY-RS14583

TLR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TLR3 Human Pre-designed siRNA Set A contains three designed siRNAs for TLR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TLR3 Human Pre-designed siRNA Set A TLR3 Human Pre-designed siRNA Set A

HY-RS14584

Tlr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tlr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tlr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tlr3 Mouse Pre-designed siRNA Set A Tlr3 Mouse Pre-designed siRNA Set A

HY-RS14585

Tlr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tlr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tlr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tlr3 Rat Pre-designed siRNA Set A Tlr3 Rat Pre-designed siRNA Set A

HY-148980

Polyinosinic acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .

HY-148980A

Polyinosinic acid sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Polyinosinic acid sodium is the sodium form of Polyinosinic acid (HY-148980). Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation .

HY-101929

CU-CPT17e 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates *TLR3, TLR8, and TLR9*.

HY-150739A

ODN 21158 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21158 sodium is a potent G-modified *TLR3* and *TLR9* inhibitor. ODN 21158 sodium inhibits IFN-α secretion in a dose dependent manner .

HY-150739

ODN 21158	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21158 is a potent G-modified *TLR3* and *TLR9* inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 inhibits IFN-α secretion in a dose dependent manner .

HY-150738

ODN 2088	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 2088 is a potent *TLR3, TLR7* and *TLR9* inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 ^[3].

HY-150738C

ODN 2088 sodium	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
ODN 2088 sodium is a potent *TLR3, TLR7* and *TLR9* inhibitor. ODN 2088 sodium shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 ^[3].

HY-135748

Polyinosinic-polycytidylic acid sodium Maximum Cited Publications 13 Publications Verification Poly(I:C) sodium	Toll-like Receptor (TLR) Apoptosis	Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .

HY-134958

Polyinosinic-polycytidylic acid potassium Poly(I:C) potassium	Toll-like Receptor (TLR) Apoptosis	Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis ^[3].

HY-150738A

Biotin-labeled ODN 2088 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Biotin-labeled ODN 2088 (sodium) is a potent *TLR3, TLR7* and *TLR9* inhibitor. Biotin-labeled ODN 2088 (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150738B

FITC-labeled ODN 2088 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
FITC-labeled ODN 2088 (sodium) is a potent *TLR3, TLR7* and *TLR9* inhibitor. FITC-labeled ODN 2088 (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-116961

TH1020 4 Publications Verification	Toll-like Receptor (TLR) Bacterial	Infection Inflammation/Immunology
TH1020 is a potent and selective *toll-like receptor 5 (TLR5)/flagellin complex* antagonist with an IC₅₀ of 0.85 μM. TH1020 inhbits flagellin-induced *TLR5* signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8 .

HY-107202A

Poly (I:C):Kanamycin (1:1) Maximum Cited Publications 13 Publications Verification	Toll-like Receptor (TLR)	Infection
Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Kanamycin is positively charged (poly-NH3) and can thus neutralize the negative charge of Poly I:C and thereby stabilized the molecule.

HY-135748A

Poly (I:C):Kanamycin (1:1) (sodium) Maximum Cited Publications 13 Publications Verification	Toll-like Receptor (TLR) Apoptosis	Infection Cancer
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a *TLR3* and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia ^[3] .

HY-107202

Polyinosinic-polycytidylic acid Maximum Cited Publications 13 Publications Verification Poly(I:C)	Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related	Infection Inflammation/Immunology Cancer
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .

HY-134581

Enpatoran 3 Publications Verification M5049	Toll-like Receptor (TLR)	Inflammation/Immunology
Enpatoran (M5049) is a potent, orally active and dual *TLR7/8* inhibitor with IC₅₀s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo. Enpatoran can be used for both innate and adaptive autoimmunity blocking research .

HY-134581A

Enpatoran hydrochloride 3 Publications Verification M5049 hydrochloride	Toll-like Receptor (TLR)	Inflammation/Immunology
Enpatoran (M5049) hydrochloride is a potent, orally active and dual *TLR7/8* inhibitor with IC₅₀s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research .

HY-N12110

SMU-CX1	Toll-like Receptor (TLR) SARS-CoV	Infection
SMU-CX1 is a specific TLR3 inhibitor (IC₅₀: 0.11 μM) with IC₅₀ ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC₅₀ of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .

HY-103241

Ro 90-7501 1 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner ^[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

SMU-CX1	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants	Toll-like Receptor (TLR) SARS-CoV
SMU-CX1 is a specific TLR3 inhibitor (IC₅₀: 0.11 μM) with IC₅₀ ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC₅₀ of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .

Species:	Human (1) Mouse (3) Cynomolgus (1)
Tag:	His (5)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77859

	TLR3 Protein, Human (HEK293, His) TLR3; CD283; IIAE2	Human	HEK293
	The TLR3 Protein, a pivotal Toll-like receptor family member, plays an essential role in the innate immune system's recognition of pathogen-associated molecular patterns, particularly viral double-stranded RNA. Its study enhances understanding of immune responses, offering potential applications in vaccine development and antiviral therapies. TLR3's classification within the Toll-like receptor family underscores its unique contributions to host defense against viral infections. Further exploration promises to enhance our knowledge of its role in both normal immune surveillance and pathological conditions. TLR3 Protein, Human (HEK293, His) is the recombinant human-derived TLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of TLR3 Protein, Human (HEK293, His) is 681 a.a., with molecular weight of 90-115 kDa.

HY-P73587

	TLR3 Protein, Mouse (sf9, His) Toll-like receptor 3; CD283; TLR3	Mouse	Sf9 insect cells
	TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (sf9, His) is the recombinant mouse-derived TLR3 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TLR3 Protein, Mouse (sf9, His) is 677 a.a., with molecular weight of 75-80 kDa.

HY-P73588

	TLR3 Protein, Mouse (705a.a, HEK293, His) Toll-like receptor 3; CD283; TLR3	Mouse	HEK293
	TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (705a.a, HEK293, His) is the recombinant mouse-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TLR3 Protein, Mouse (705a.a, HEK293, His) is 705 a.a., with molecular weight of 100-110 kDa.

HY-P78362

	TLR3 Protein, Mouse (681a.a, HEK293, His) TLR3; CD283; IIAE2	Mouse	HEK293
	TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (681a.a, HEK293, His) is the recombinant mouse-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TLR3 Protein, Mouse (681a.a, HEK293, His) is 681 a.a., with molecular weight of 85-110 kDa.

HY-P700835

	TLR3 Protein, Cynomolgus (681a.a, HEK293, His) TLR3; CD283; IIAE2	Cynomolgus	HEK293
	TLR3 Protein, part of the Toll-like receptor family, is vital in innate immunity, specifically detecting viral double-stranded RNA. Its recognition initiates a signaling cascade, leading to pro-inflammatory cytokine production and immune cell activation. Predominantly expressed in immune cells like dendritic cells, TLR3's activation is crucial for antiviral defense. Dysregulated TLR3 signaling links to autoimmune and inflammatory diseases, highlighting its potential therapeutic relevance, warranting further research to fully comprehend its immune response role. TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is the recombinant cynomolgus-derived TLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is 681 a.a., with molecular weight of 95-115 kDa.


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Toll-Like Receptor 3 Antibody (YA659) CD283; CD283 antigen; IIAE2; TLR 3; TLR3; TLR3_HUMAN; Toll Like Receptor 3; Toll-like receptor 3.	WB	Transfected
Toll-Like Receptor 3 Antibody (YA659) is a non-conjugated and Mouse origined monoclonal antibody about 104 kDa, targeting to Toll-Like Receptor 3 (2F10). It can be used for WB assays with tag free, in the background of Transfected.

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