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Results for "

TNF-R1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (9) Apoptosis (4) Bacterial (1) Flavivirus (3) NF-κB (3) SARS-CoV (1) Ser/Thr Protease (3)
By Research Areas:	Cancer (5) Infection (4) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990008

Atrosab	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated apoptosis induction and IL-6 and IL-8 production. Atrosab can be used for research of inflammatory disease ^[1].

HY-111255

SPD304 4 Publications Verification	TNF Receptor	Cancer
SPD304 is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α ^[1] .

HY-P9970

Infliximab 5+ Cited Publications Avakine; CT-P13	TNF Receptor Bacterial	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] .

HY-111255A

SPD304 dihydrochloride 4 Publications Verification	TNF Receptor	Inflammation/Immunology
SPD304 dihydrochloride is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α ^[1] .

HY-B0190

Nafamostat	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall ^[1] ^3] .

HY-B0190B

Nafamostat hydrochloride	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall ^[1] ^3] .

HY-133807

Benpyrine 1 Publications Verification	TNF Receptor	Inflammation/Immunology
Benpyrine is a highly specific and orally active *TNF-α* inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to *TNF-α* and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 µM. Benpyrine has the potential for *TNF-α* mediated inflammatory and autoimmune disease research ^[1].

HY-B0190A

Nafamostat mesylate Maximum Cited Publications 10 Publications Verification FUT-175	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall ^[1] ^3] .

HY-134471

TNF-α-IN-2 1 Publications Verification	TNF Receptor	Inflammation/Immunology
TNF-α-IN-2 is a potent and orally active inhibitor of *tumor necrosis factor alpha (TNFα), with an IC₅₀* of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis ^[1].

HY-133807B

(R)-Benpyrine	Others	Inflammation/Immunology
(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active *TNF-α* inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to *TNF-α* and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 μM. Benpyrine has the potential for *TNF-α* mediated inflammatory and autoimmune disease research ^[1].

HY-D1270

Direct Violet 1	SARS-CoV	Infection
Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC₅₀s of 1.47-2.63 μM ^[1] .

Cat. No.	Product Name	Type

HY-D1270

Direct Violet 1	Dyes
Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC₅₀s of 1.47-2.63 μM ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P990008

Atrosab	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated apoptosis induction and IL-6 and IL-8 production. Atrosab can be used for research of inflammatory disease ^[1].

HY-P9970

Infliximab 5+ Cited Publications Avakine; CT-P13	TNF Receptor Bacterial	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] .

Species:	Human (5) Mouse (3) Rat (2) Cynomolgus (1)
Tag:	His (5) Tag Free (2) GST (1) Fc (3)
Source:	HEK293 (7) CHO (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72443

	TNF RI/TNFRSF1A Protein, Mouse Tumor necrosis factor receptor superfamily member 1A; TNF-R1; CD120a; TNFrsf1a	Mouse	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse is expressed by E. coli and has a transmembrane region (I22-A212).

HY-P700838

	TNFRSF1A Protein, Cynomolgus (HEK293, His) TNF-R1; TNF-RI; FPF; TBP1; TNF-R55; TNFAR; TNFR60; p55; p60; MS5; p55-R; TNFR1-d2	Cynomolgus	HEK293
	TNFRSF1A Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. TNFRSF1A Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TNFRSF1A protein, expressed by HEK293 , with C-His labeled tag. The total length of TNFRSF1A Protein, Cynomolgus (HEK293, His) is 182 a.a., with molecular weight of 32-42 kDa.

HY-P73450

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (M1-A212) with a His tag at the C-terminus.

HY-P73449

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (M1-A212) with a Fc tag at the C-terminus.

HY-P74505

	TNFRSF1A Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, Fc) is expressed by HEK293 and has a transmembrane region (M1-A211) with a Fc tag at the C-terminus.

HY-P74504

	TNFRSF1A Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus.

HY-P70801

	TNFRSF1A Protein, Human (His) Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (His) is expressed by E. coli and has a transmembrane region (I22-T211) with a 6*His tag at the N-terminus.

HY-P700263

	TNFR-1/CD120a Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, His) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-8*His labeled tag. The total length of TNFR-1/CD120a Protein, Human (HEK293, His) is 182 a.a., with molecular weight of 28-38 kDa.

HY-P700264

	TNFR-1/CD120a Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, Fc) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TNFR-1/CD120a Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of 55-70 kDa.

HY-P702570

	TRADD Protein, Human (GST) TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein	Human	E. coli
	TRADD protein acts as an adapter for TNFRSF1A/TNFR1, mediating its interaction with FADD. TRADD induces TNF-induced responses: apoptosis and NF-kappa-B activation. The nuclear form of TRADD functions as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A. Stimulation of TNFRSF1A forms plasma membrane-bound complex I, promoting cell survival. Subsequently, TRADD dissociates to form cytoplasmic complex II, inducing apoptosis. TRADD interacts with various proteins in these complexes, emphasizing its multifaceted role in cellular processes. TRADD Protein, Human (GST) is the recombinant human-derived TRADD protein, expressed by E. coli, with N-GST labeled tag. The total length of TRADD Protein, Human (GST) is 312 a.a., with molecular weight of 61.2 kDa.

HY-P7305

	TNFRSF1A Protein, Human (CHO) rHuTNFRI; TNFRSF1A; TNFAR; CD120a	Human	CHO
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (CHO) is expressed by CHO and has a transmembrane region (D41-N201) .


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Cat. No.	Product Name	Application	Reactivity

HY-P82531

TRADD Antibody (YA2276)

AA930854; TNFR1 associated DEATH domain protein; tradd
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

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