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Isoforms Recommended:	TNKS2/PARP5B

Results for "

TNKS2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bcr-Abl (1) CDK (1) Cyclin G-associated Kinase (GAK) (1) Ferroptosis (1) LIM Kinase (LIMK) (1) MAP4K (1) MAPKAPK2 (MK2) (1) PARP (20) PROTACs (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (4) Tyrosinase (3) ULK (1) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-23338

TNKS-2-IN-1

PARP Others

TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC₅₀s of 259 nM and 1100 nM .

TNKS-2-IN-1	PARP	Others
TNKS-2-IN-1 (Compound 13g) is a *TNKS-2* inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC₅₀s of 259 nM and 1100 nM .

HY-RS14843

TNKS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNKS2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNKS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNKS2 Human Pre-designed siRNA Set A TNKS2 Human Pre-designed siRNA Set A

HY-RS14844

Tnks2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnks2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnks2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnks2 Mouse Pre-designed siRNA Set A Tnks2 Mouse Pre-designed siRNA Set A

HY-RS14845

TNKS2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNKS2 Rat Pre-designed siRNA Set A contains three designed siRNAs for TNKS2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNKS2 Rat Pre-designed siRNA Set A TNKS2 Rat Pre-designed siRNA Set A

HY-156332

TNKS-2-IN-2

PARP Cancer

TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC₅₀ of 22 nM .
HY-143338

ART-IN-1

PARP Cancer

ART-IN-1 (compound 7) is a selective PARP inhibitor with IC₅₀s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively .

TNKS-2-IN-2	PARP	Cancer
TNKS-2-IN-2 is a potent and selective inhibitor of *TNKS2* with an IC₅₀ of 22 nM .

ART-IN-1	PARP	Cancer
ART-IN-1 (compound 7) is a selective PARP inhibitor with IC₅₀s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively .

HY-12418

Stenoparib 1 Publications Verification E7449; 2X-121	PARP	Cancer
Stenoparib (E7449) is a potent PARP1 and *PARP2* inhibitor and also inhibits TNKS1 and *TNKS2, with IC₅₀s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2*, respectively, using ³²P-NAD ⁺ as substrate.

HY-121719

TIQ-A

PARP Cardiovascular Disease Cancer

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC₅₀ of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent .
HY-12438

G007-LK

5+ Cited Publications

PARP Cancer

G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC₅₀s of 46 nM and 25 nM, respectively.

TIQ-A	PARP	Cardiovascular Disease Cancer
TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC₅₀ of 24 nM for *TNKS2*. TIQ-A is a potential anti-ischemic agent .

G007-LK 5+ Cited Publications	PARP	Cancer
G007-LK is a potent and selective inhibitor of TNKS1 and *TNKS2, with IC₅₀*s of 46 nM and 25 nM, respectively.

HY-16910

WIKI4 2 Publications Verification	PARP β-catenin	Cancer
WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for *TNKS2. WIKI4 potently inhibits Wnt/β-catenin* signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of *TNKS2* ^[2]. WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM .

HY-13990

*NVP-TNKS656* TNKS656	PARP Apoptosis	Cancer
NVP-TNKS656 is a highly potent, selective, and orally active *TNKS2* inhibitor with IC₅₀ of 6 nM, and is > 300 fold selectivity against PARP1 and *PARP2*.

HY-U00422

K-756	PARP	Cancer
K-756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP-ribosylation activity of TNKS1 and *TNKS2* with IC₅₀s of 31 and 36 nM, respectively.

HY-15147

XAV-939 Maximum Cited Publications 115 Publications Verification	β-catenin PARP	Cancer
XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC₅₀ values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation ^[2] .

HY-19351

MN-64 3 Publications Verification	PARP	Cancer
MN-64 is a potent tankyrase 1 inhibitor, with IC₅₀s of 6 nM, 72 nM, 19.1 μM, and 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively.

HY-153332

Tankyrase-IN-5	PARP	Cancer
Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and *TNKS2* inhibitor with IC₅₀s of 2.3 nM and 7.9 nM, respectively .

HY-146336

*PARP1/2/TNKS1/2-IN-1*	PARP Apoptosis	Cancer
PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, *PARP-2, TNKS1* and *TNKS2* inhibitor with IC₅₀ values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis .

HY-147886

PARP1-IN-11	PARP	Cancer
PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with IC₅₀ value of 0.082 µM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2 .

HY-126248

Tankyrase-IN-2	PARP	Cancer
Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC₅₀s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model .

HY-12975

AZ6102 1 Publications Verification	PARP	Cancer
AZ6102 is a potent dual TNKS1 and *TNKS2* inhibitor, with IC₅₀s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC₅₀s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively.

HY-123851

MSC2504877 M2912	PARP	Cancer
MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC₅₀s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity .

HY-145111

TNK2-IN-1

Tyrosinase Cancer

TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer .

TNK2-IN-1	Tyrosinase	Cancer
TNK2-IN-1 is a *TNK2* inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer .

HY-RS14838

TNK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNK2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNK2 Human Pre-designed siRNA Set A TNK2 Human Pre-designed siRNA Set A

HY-15811

XMD8-87

ACK1-B19
Tyrosinase Cancer

XMD8-87 is a potent TNK2 inhibitor with IC₅₀ values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
HY-101243

XMD16-5

Tyrosinase Cancer

XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

XMD8-87 ACK1-B19	Tyrosinase	Cancer
XMD8-87 is a potent *TNK2* inhibitor with IC₅₀ values of 38 and 113 nM for the D163E and R806Q mutations, respectively.

XMD16-5	Tyrosinase	Cancer
XMD16-5 is a potent *TNK2* inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

HY-153259

TNKS1/2-IN-2	PARP	Cancer
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC₅₀ values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC₅₀ values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer .

HY-145267

OM-153	PARP Wnt	Cancer
OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM ^[2].

HY-145266

OM-1700	PARP	Cancer
OM-1700 is a potent tankyrase inhibitor with IC₅₀s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI₅₀=650 nM) .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Others
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

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TNKS2

Inhibitors & Agonists