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Isoforms Recommended:	TRPA

Results for "

TRPA1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Endogenous Metabolite (3) Fungal (1) GPR119 (1) NADPH Oxidase (1) RAR/RXR (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1) TRP Channel (40)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (16) Metabolic Disease (2) Neurological Disease (20)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153711

TRPA1-IN-2	TRP Channel	Inflammation/Immunology
TRPA1-IN-2 (compound 1) is a potent and orally active *TRPA1* inhibitor with an IC₅₀ value of 0.04 µM. TRPA1-IN-2 shows anti-inflammation activity ^[1].

HY-139904

TRPA1 Antagonist 3

TRP Channel Others

TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel.

TRPA1 Antagonist 3	TRP Channel	Others
TRPA1 Antagonist 3 is a photoswitchable *TRPA1* agonist that enables optical control of the TRPA1 channel.

HY-111494

TRPA1 Antagonist 1	TRP Channel	Neurological Disease
TRPA1 Antagonist 1 is a methylene phosphate proagent which converts to its active parent agent, a *TRPA1* antagonist with an IC₅₀ of 8 nM.

HY-RS15103

TRPA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPA1 Human Pre-designed siRNA Set A TRPA1 Human Pre-designed siRNA Set A

HY-142214

TRPA1-IN-1

TRP Channel Others

TRPA1-IN-1 is a potent, selective, and orally bioavailable TRPA1 small molecule antagonist.
HY-120689

PF-04745637

TRP Channel Inflammation/Immunology

PF-04745637 is a potent and selective TRPA1 antagonist with an IC₅₀ of 17 nM for human TRPA1 ^[1].

TRPA1-IN-1	TRP Channel	Others
TRPA1-IN-1 is a potent, selective, and orally bioavailable *TRPA1* small molecule antagonist.

PF-04745637	TRP Channel	Inflammation/Immunology
PF-04745637 is a potent and selective *TRPA1* antagonist with an IC₅₀ of 17 nM for human TRPA1 ^[1].

HY-12809

Optovin 1 Publications Verification	TRP Channel	Neurological Disease
Optovin is a reversible photoactivated *TRPA1* ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues ^[1].

HY-115877

GDC-0334	TRP Channel	Others
GDC-0334 is a selective *TRPA1* antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma ^[1] .

HY-135013

Umbellulone	TRP Channel	Neurological Disease
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism ^[1].

HY-156684

GDC-6599

TRP Channel Others

GDC-6599 (Example 8) is an orally active TRPA1 inhibitor. GDC-6599 can be used to study TRPA1-mediated diseases such as pain ^[1].

GDC-6599	TRP Channel	Others
GDC-6599 (Example 8) is an orally active *TRPA1* inhibitor. GDC-6599 can be used to study TRPA1-mediated diseases such as pain ^[1].

HY-108463

A-967079 5+ Cited Publications	TRP Channel	Inflammation/Immunology
A-967079 is a selective *TRPA1* receptor antagonist with IC₅₀s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS.

HY-18779

PF-4840154 1 Publications Verification	TRP Channel	Inflammation/Immunology
PF-4840154 is a potent, selective agonist of the rat and human *TrpA1* channel with EC₅₀s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse ^[1].

HY-121636

Resolvin D2 4 Publications Verification RvD2	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of *TRPV1* (IC₅₀ = 0.1 nM) and *TRPA1* (IC₅₀ = 2 nM) in primary sensory neurons ^[1] .

HY-121539

Supercinnamaldehyde	TRP Channel	Neurological Disease
Supercinnamaldehyde is a potent transient receptor potential ankyrin 1 (TRPA1) activator with an EC₅₀ value of 0.8 μM. Supercinnamaldehyde activates TRPA1 ion channels through covalent modification of cysteines ^[1].

HY-111132

JT010

1 Publications Verification

TRP Channel Cancer

JT010 is a potent agonist of TRPA1 with an EC₅₀ of 0.65 nM.

JT010 1 Publications Verification	TRP Channel	Cancer
JT010 is a potent agonist of *TRPA1* with an EC₅₀ of 0.65 nM.

HY-W014421

AP-18	TRP Channel	Neurological Disease
AP-18, a potent and selective *TRPA1* inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC₅₀ of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 reverses complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC₅₀ of 10.3 μM ^[1] .

HY-15065

Chembridge-5861528 TCS 5861528	TRP Channel	Neurological Disease Metabolic Disease Inflammation/Immunology
Chembridge-5861528 (TCS 5861528) is a potent *TRPA1* channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC₅₀ values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities ^[1].

HY-N7965

Methyl kakuol

TRP Channel Neurological Disease

Methyl kakuol shows agonistic activity against TRPA1 with an EC₅₀ of 0.27 µM ^[1].
HY-N2318

Podocarpic acid

TRP Channel Neurological Disease

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

Methyl kakuol	TRP Channel	Neurological Disease
Methyl kakuol shows agonistic activity against *TRPA1* with an EC₅₀ of 0.27 µM ^[1].

Podocarpic acid	TRP Channel	Neurological Disease
Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel *TRPA1* activator.

HY-N1500

Pulegone 1 Publications Verification	TRP Channel Endogenous Metabolite	Inflammation/Immunology
Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents ^[1]. The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .

HY-W106234

4-(Phenyldiazenyl)benzoic acid	TRP Channel	Others
4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable *TRPA1* agonist that can be used as pharmacological tools for study of pain signaling.

HY-N8264

Moringin	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities ^[1] .

HY-101907

ASP7663 1 Publications Verification	TRP Channel	Neurological Disease
ASP7663 is an orally active and selective *TRPA1* agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions ^[1] .

HY-100965

Diphenyleneiodonium chloride Maximum Cited Publications 32 Publications Verification DPI	TRP Channel NADPH Oxidase Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a *TRPA1* activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-W002116

Methyl syringate	TRP Channel	Inflammation/Immunology
Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a *TRPA1* agonist ^[1] .

HY-114524

(E)-4-Oxo-2-nonenal 4-ONE	TRP Channel	Cardiovascular Disease
(E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist ^[1] .

HY-107436

LE135 1 Publications Verification	RAR/RXR TRP Channel	Neurological Disease Cancer
LE135 is a potent RAR antagonist that binds selectively to RARα (K_i of 1.4 μM) and RARβ (K_i of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent *TRPV1* and TRPA1 receptors activator with EC₅₀s of 2.5 μM and 20 μM, respectively ^[1] .

HY-108329

AM-0902	TRP Channel	Neurological Disease Inflammation/Immunology
AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC₅₀s of 71 and 131 nM for *rTRPA1* and *hTRPA1*, respectively.

HY-N7117

1,4-Cineole	TRP Channel Endogenous Metabolite	Inflammation/Immunology Cancer
1,4-Cineole is a widely distributed, natural, oxygenated monoterpene ^[1]. 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human *TRPA1* .

HY-N12605

hTRPA1-IN-1	TRP Channel	Neurological Disease
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM ^[1].

HY-15064

HC-030031 15+ Cited Publications	TRP Channel	Neurological Disease
HC-030031 is a potent and selective *TRPA1* inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC₅₀s of 6.2±0.2 and 5.3±0.2 μM, respectively.

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	TRP Channel Endogenous Metabolite	Neurological Disease
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 µM, respectively. Hydroxy-α-sanshool can be used for pain research ^[1] .

HY-W002116S

Methyl syringate-d6	TRP Channel	Inflammation/Immunology
Methyl syringate-d₆ is the deuterium labeled Methyl syringate[1]. Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a TRPA1 agonist[2][3][4].

HY-134098

Diisopropyl adipate Adipic acid diisopropyl ester	TRP Channel	Others
Diisopropyl adipate is an alternative plasticizer and a *TRPA1* activator. Diisopropyl adipate activates TRPA1 and enhances FITC-induced contact hypersensitivity (CHS).Diisopropyl adipate also serves as an ingredient in cosmetics and drug formulations topically applied to the skin. Diisopropyl adipate can be used as an excipient, such as emollients, plasticizers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs ^[1] .

HY-N6810

Thymol 3 Publications Verification	Bacterial Fungal Apoptosis	Infection Inflammation/Immunology Cancer
Thymol is a *TRPA1* agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects ^[1].

HY-18662

RQ-00203078 2 Publications Verification	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels ^[1] .

HY-148236

BAY-390	TRP Channel	Inflammation/Immunology
BAY-390 is a selective, across species active and brain penetrating *TRPA1* inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC₅₀s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation ^[1].

HY-101507

Pico145 5+ Cited Publications HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 ^[1].

HY-121636S

Resolvin D2-d5 RvD2-d₅	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-107535

AS1269574	GPR119 TRP Channel	Metabolic Disease
AS1269574 is a potent, orally available GPR119 agonist, with an EC₅₀ of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes ^[1] .

HY-104061

AMG8788

TRP Channel Others

AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 63.2 nM ^[1].
HY-104062

AMG9678

TRP Channel Others

AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 31.2 nM ^[1].

AMG8788	TRP Channel	Others
AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 63.2 nM ^[1].

AMG9678	TRP Channel	Others
AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 31.2 nM ^[1].

Wasabi Receptor Toxin WaTx	Peptides	Neurological Disease
Wasabi Receptor Toxin (WaTx) active *TRPA1* by prolonged channel openings and decreased Ca ²⁺ permeability. Wasabi Receptor Toxin can be used in the research of acute and persistent pain ^[1].

Umbellulone	Other Monoterpenes Terpenoids Source classification Myrtaceae Plants Myrtus communis L.	TRP Channel
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism ^[1].

Species:	Human (2)
Tag:	His (1) MBP (1) Flag (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702566

	TRPA1 Protein, Human (HEK293, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor	Human	HEK293

HY-P701382

	TRPA1 Protein, Human (HEK293, His, MBP, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag. The total length of TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is 1118 a.a. .

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