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Results for "

TTR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Transthyretin (TTR) (20) 5-HT Receptor (1) COX (1) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (9)
By Research Areas:	Cancer (1) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (4) Neurological Disease (17)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Transthyretin (TTR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153577

WT-TTR inhibitor 1

Transthyretin (TTR) Neurological Disease

WT-TTR inhibitor 1 (Compound 21) is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM .

*WT-TTR* inhibitor 1**	Transthyretin (TTR)	Neurological Disease
WT-TTR inhibitor 1 (Compound 21) is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM .

HY-RS15238

TTR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TTR Human Pre-designed siRNA Set A contains three designed siRNAs for TTR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TTR Human Pre-designed siRNA Set A TTR Human Pre-designed siRNA Set A

HY-RS15239

Ttr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ttr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ttr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttr Mouse Pre-designed siRNA Set A Ttr Mouse Pre-designed siRNA Set A

HY-RS15240

Ttr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ttr Rat Pre-designed siRNA Set A contains three designed siRNAs for Ttr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ttr Rat Pre-designed siRNA Set A Ttr Rat Pre-designed siRNA Set A

HY-160612

Transthyretin-IN-2	Transthyretin (TTR)	Neurological Disease
Transthyretin-IN-2 (Compound 36) is a transthyretin (TTR) amyloidsis inhibitor, with IC₅₀ and pIC₅₀ values of 1.31 μM and 5.88 μM. Transthyretin-IN-2 can be used for the research of TTR amyloidosis diseases .

HY-132609

Patisiran sodium	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the *transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR* amyloidosis .

HY-132608

Inotersen sodium ISIS-420915 sodium	Transthyretin (TTR)	Neurological Disease
Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy .

HY-148089

Eplontersen	Transthyretin (TTR)	Neurological Disease
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-148089A

Eplontersen sodium	Transthyretin (TTR)	Neurological Disease
Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-14852

Tafamidis 1 Publications Verification	Transthyretin (TTR)	Neurological Disease
Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC₅₀s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis .

HY-14852A

Tafamidis meglumine 1 Publications Verification Fx-1006A	Transthyretin (TTR)	Neurological Disease
Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC₅₀s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis .

HY-14852S

Tafamidis-d3	Transthyretin (TTR) Isotope-Labeled Compounds	Neurological Disease
Tafamidis-d₃ is deuterium labeled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].

HY-153609

AS-Patisiran sodium	Transthyretin (TTR) Small Interfering RNA (siRNA)	Neurological Disease
AS-Patisiran sodium is an antisense strand of Patisiran. Patisiran is a double-stranded small interfering RNA that targets a sequence within the *transthyretin (TTR) messenger RNA. Patisiran specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran can be used for the research of hereditary TTR* amyloidosis .

HY-113950

Dichlorophenyl-ABA	Transthyretin (TTR)	Neurological Disease
Dichlorophenyl-ABA is an inhibitor of *transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR* L55P-expressing cells .

HY-132590A

Revusiran sodium ALN-TTRSC sodium	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Revusiran sodium is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran sodium can be used for transthyretin (TTR)-mediated amyloidosis research .

HY-132590

Revusiran ALN-TTRSC	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research .

HY-112974

Inotersen

GSK-2998728; ISIS-420915
Transthyretin (TTR) Others

Inotersen is an antisense oligonucleotide that inhibits hepatic production of transthyretin (TTR).

Inotersen GSK-2998728; ISIS-420915	Transthyretin (TTR)	Others
Inotersen is an antisense oligonucleotide that inhibits hepatic production of transthyretin (TTR).

HY-147366

RBP4 ligand-1	Others	Metabolic Disease
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4_SPA IC₅₀ and RBP4–TTR FRET IC₅₀ values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively .

HY-155299

PITB	Transthyretin (TTR)	Neurological Disease
PITB is a selective and orally active transthyretin (TTR) aggregation inhibitor. PITB can be used for transthyretin amyloidosis (ATTR) disease research .

HY-132589A

Vutrisiran sodium ALN-TTRsc02 sodium	Small Interfering RNA (siRNA)	Neurological Disease
Vutrisiran sodium is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. Vutrisiran sodium can be used for transthyretin (TTR)-mediated amyloidosis research .

HY-146137

Transthyretin-IN-1	Transthyretin (TTR)	Neurological Disease
Transthyretin-IN-1 (Compound 1d) is a transthyretin (TTR) fibril formation inhibitor. Transthyretin-IN-1 can be used for Alzheimer’s disease research .

HY-132589

Vutrisiran ALN-TTRsc02	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Vutrisiran (ALN-TTRsc02) is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. Vutrisiran can be used for transthyretin (TTR)-mediated amyloidosis research .

HY-109165

Acoramidis AG10	Transthyretin (TTR)	Metabolic Disease Endocrinology
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis .

HY-109165A

Acoramidis hydrochloride AG10 hydrochloride	Transthyretin (TTR)	Metabolic Disease Endocrinology
Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis .

HY-N1957

Gamma-Mangostin 1 Publications Verification γ-Mangostin	5-HT Receptor COX Transthyretin (TTR)	Metabolic Disease Inflammation/Immunology Cancer
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

Gamma-Mangostin 1 Publications Verification γ-Mangostin	Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Metabolic Disease Plants Disease Research Fields	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .

Species:	Human (3) Mouse (1) Cynomolgus (1)
Tag:	His (4) Myc (2) Fc (1)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P73455

	*Transthyretin/TTR* Protein, Human (147a.a, HEK293, His)** Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB	Human	HEK293
	The transthyretin/TTR protein is a thyroid hormone binder that may be critical for transporting thyroxine from the bloodstream to the brain. Its structure is a homotetramer, forming a dimer of dimers, and its central channel is suggested to play a role in thyroxine binding and transport. Transthyretin/TTR Protein, Human (147a.a, HEK293, His) is the recombinant human-derived Transthyretin/TTR protein, expressed by HEK293 , with C-His labeled tag. The total length of Transthyretin/TTR Protein, Human (147a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.98 kDa.

HY-P73580

	*Transthyretin/TTR* Protein, Mouse (HEK293, His)** Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB	Mouse	HEK293
	The transthyretin/TTR protein is a thyroid hormone binder that may transport thyroxine from the blood to the brain. It exists as a homotetramer forming a dimer of dimers with a ligand-regulated central channel suggested to play a role in thyroxine binding and transport. Transthyretin/TTR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transthyretin/TTR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Transthyretin/TTR Protein, Mouse (HEK293, His) is 127 a.a., with molecular weight of ~16.4 kDa.

HY-P70500

	*Transthyretin/TTR* Protein, Human (127a.a, HEK293, His)** Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB	Human	HEK293
	The transthyretin/TTR protein is a thyroid hormone binder that may be critical for transporting thyroxine from the bloodstream to the brain. Its structure is a homotetramer, forming a dimer of dimers, and its central channel is suggested to play a role in thyroxine binding and transport. Transthyretin/TTR Protein, Human (127a.a, HEK293, His) is the recombinant human-derived Transthyretin/TTR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Transthyretin/TTR Protein, Human (127a.a, HEK293, His) is 127 a.a., with molecular weight of (16-21) & (31-37) kDa, respectively.

HY-P71671

	*Transthyretin/TTR* Protein, Cynomolgus (HEK293, His)** TTR; QccE-10711; QccE-14396; Transthyretin; Prealbumin	Cynomolgus	HEK293
	Transthyretin (TTR) is a thyroid hormone-binding protein that may be involved in transporting thyroxine from the blood to the brain. As a homotetramer, TTR forms a dimer of dimers with a ligand-regulated central channel. Transthyretin/TTR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Transthyretin/TTR protein, expressed by HEK293 , with N-His, N-Myc labeled tag. The total length of Transthyretin/TTR Protein, Cynomolgus (HEK293, His) is 127 a.a., with molecular weight of ~18 kDa.

HY-P72026

	*Transthyretin/TTR* Protein, Human (HEK293, Fc-Myc)** ATTR Prealbumin; TBPA; PALB	Human	HEK293
	The transthyretin/TTR protein is a thyroid hormone binder that may be critical for transporting thyroxine from the bloodstream to the brain. Its structure is a homotetramer, forming a dimer of dimers, and its central channel is suggested to play a role in thyroxine binding and transport. Transthyretin/TTR Protein, Human (HEK293, Fc-Myc) is the recombinant human-derived Transthyretin/TTR protein, expressed by HEK293 , with C-hFc, C-Myc labeled tag. The total length of Transthyretin/TTR Protein, Human (HEK293, Fc-Myc) is 127 a.a., with molecular weight of ~47 kDa.


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Tafamidis-d3
Tafamidis-d₃ is deuterium labeled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].

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