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Results for "

TYRO3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) c-Met/HGFR (4) FLT3 (2) Small Interfering RNA (siRNA) (1) TAM Receptor (10)
By Research Areas:	Cancer (11) Inflammation/Immunology (1)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124502

UNC4203	TAM Receptor FLT3	Cancer
UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC₅₀s of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively .

HY-12494

LDC1267 5+ Cited Publications	TAM Receptor	Inflammation/Immunology Cancer
LDC1267 is a highly selective *TAM (Tyro3, Axl and Mer)* kinase inhibitor with IC₅₀s of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively .

HY-117596

UNC569 1 Publications Verification	TAM Receptor	Cancer
UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC₅₀ of 2.9 nM and a K_i of 4.3 nM. UNC569 also inhibits Axl and *Tyro3* with IC₅₀s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research

HY-15797

UNC2250 1 Publications Verification	TAM Receptor	Cancer
UNC2250 is a potent and selective Mer inhibitor with an IC₅₀ of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

HY-RS15308

TYRO3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TYRO3 Human Pre-designed siRNA Set A contains three designed siRNAs for TYRO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TYRO3 Human Pre-designed siRNA Set A TYRO3 Human Pre-designed siRNA Set A

HY-147218

TAM&Met-IN-1	c-Met/HGFR TAM Receptor	Cancer
TAM&Met-IN-1 is a potent TAM and c-Met kinase inhibitor with IC₅₀ values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. TAM&Met-IN-1 can be used for researching anticancer .

HY-125510

UNC2541 1 Publications Verification	TAM Receptor	Others
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC₅₀ of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC₅₀, 510 nM) .

HY-132200

UNC5293	TAM Receptor Anaplastic lymphoma kinase (ALK) FLT3	Cancer
UNC5293 is a MERTK-selective and potent inhibitor (K_i=190 pM). UNC5293 inhibits MERTK (IC₅₀=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research .

HY-116000

Glumetinib 1 Publications Verification Gumarontinib; SCC244	c-Met/HGFR	Cancer
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .

HY-12076

BMS 777607 Maximum Cited Publications 10 Publications Verification BMS 817378	c-Met/HGFR TAM Receptor	Cancer
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and *Tyro3* with IC₅₀s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases .

HY-147695

c-Met-IN-12	c-Met/HGFR	Cancer
c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC₅₀ of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and *TYRO3* kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy .

HY-117548

UNC1062 1 Publications Verification	TAM Receptor	Cancer
UNC1062 is a MERTK-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC₅₀=1.1 nM, Morrison K_i=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC₅₀=60 nM, AXL IC₅₀=85 nM) .

HY-162085

Axl-IN-17

TAM Receptor Cancer

Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC₅₀ value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy .

Axl-IN-17	TAM Receptor	Cancer
Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC₅₀ value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy .

Recombinant Proteins Recommended:

TYRO3

Species:	Human (2) Mouse (3)
Tag:	His (2) Fc (2) Flag (1)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70043

	TYRO3/DTK Protein, Mouse (HEK293, hFc) rMuTYROsine-protein kinase receptor TYRO3/DTK, Fc; TYROsine-protein kinase receptor TYRO3; Etk2; TYRO3; TK19-2; TYROsine-protein kinase DTK; TYROsine-protein kinase RSE; TYROsine-protein kinase TIF	Mouse	HEK293
	TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation. Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules. TYRO3/DTK Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TYRO3/DTK Protein, Mouse (HEK293, hFc) is 388 a.a., with molecular weight of 90-120 kDa.

HY-P70057

	TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) rHuTYROsine-protein kinase receptor TYRO3/TYRO3, His; TYROsine-protein kinase receptor TYRO3; TYROsine-protein kinase BYK; TYROsine-protein kinase DTK; TYROsine-protein kinase RSE; TYROsine-protein kinase SKY; TYROsine-protein kinase TIF; TYRO3; BYK; DTK; RSE; SKY; TIF	Mouse	HEK293
	TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as TULP1 or GAS6. TYRO3 is activated by ligand binding and regulates cell survival, migration, and differentiation, leading to dimerization and intracellular autophosphorylation to create docking sites for downstream signaling molecules. TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is 388 a.a., with molecular weight of 55-70 kDa.

HY-P78657

	TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) TYRO3; BYK; DTK; RSE; SKY; TIF	Human	HEK293
	The TYRO3/DTK protein is a tyrosine kinase receptor. TYRO3 transduces signals from the extracellular matrix by activating the PI3K/AKT/ NF-kappa-B pathway. TYRO3 plays an important role in inhibiting Toll-like receptor (TLRs) mediated innate immune response by activating STAT1. TYRO3 has the function of promoting tumor cell survival and/or proliferation, metastasis and chemotherapy resistance. TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is the recombinant human-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is 388 a.a., with molecular weight of 85-120 kDa.

HY-P702702

	TYRO3 Protein, Human (Biotinylated, sf9, Flag) TYRO3; TYRO3 protein TYROsine kinase; RSE; TYROsine-protein kinase receptor TYRO3; Brt; Dtk; Sky; Tif; TYROsine-protein kinase DTK; TYROsine-protein kinase RSE; TYROsine-protein kinase SKY; TYROsine-protein kinase byk; BYK; FLJ16467	Human	Sf9 insect cells

HY-P77863

	TYRO3/DTK Protein, Mouse (HEK293, His) BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse	Mouse	HEK293
	TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation. Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules. TYRO3/DTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-His labeled tag. The total length of TYRO3/DTK Protein, Mouse (HEK293, His) is 389 a.a., with molecular weight of 60-75 kDa.


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