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Results for "

Thiazole

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Bacterial (5) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (1) Cholinesterase (ChE) (1) DNA Stain (1) DNA/RNA Synthesis (3) Drug Metabolite (1) EGFR (4) Endogenous Metabolite (2) Fluorescent Dye (1) Glucosidase (1) Lipoxygenase (1) P-glycoprotein (1) Parasite (2) PARP (1) Phosphodiesterase (PDE) (3) β-catenin (4)
By Research Areas:	Cancer (13) Infection (8) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0150

Thiazole Orange 1 Publications Verification	Fluorescent Dye	Others
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange can be used for reticulocyte analysis. λEx/λEm (including DNA) of Thiazole Orange =510/527 nm .

HY-69015

Thiazole-5-carboxyaldehyde Thiazole-5-carboxaldehyde; 5-FormylThiazole	Biochemical Assay Reagents	Others
Thiazole-5-carboxyaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W003182

6-Bromobenzo[d]thiazole	Biochemical Assay Reagents	Others
6-Bromobenzo[d]thiazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-148180

Antimycobacterial agent-4	Bacterial Parasite	Infection
Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line .

HY-W158239

*4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid*	Drug Metabolite	Others
4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838) .

HY-U00094

INO5042

Others Inflammation/Immunology

INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .
HY-145921

ChemR23-IN-3

Others Inflammation/Immunology

ChemR23-IN-3 is a potent thiazole-based ChemR23 inhibitor with an IC₈₀ value of 12 nM.
HY-W015695

4-Methyl-5-thiazoleethanol

Endogenous Metabolite Infection

4-Methyl-5-thiazoleethanol, a natural sulfur-containing flavor compound, is a thiazole precursor .
HY-156372

AChE-IN-44

Cholinesterase (ChE) Neurological Disease

AChE-IN-44 (Compound Tap4) is an AChE inhibitor. AChE-IN-44 can be converted into the thiazole salt AChE inhibitor Tat2 .
HY-153679

β-Catenin modulator-2

β-catenin Cancer

β-Catenin modulator-2 (compound IIa-130), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
HY-153680

β-Catenin modulator-3

β-catenin Cancer

β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
HY-153682

β-Catenin modulator-5

β-catenin Cancer

β-Catenin modulator-5 (compound IIa-84), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .
HY-153681

β-Catenin modulator-4

β-catenin Cancer

β-Catenin modulator-4 (compound IIa-92), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

INO5042	Others	Inflammation/Immunology
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .

ChemR23-IN-3	Others	Inflammation/Immunology
ChemR23-IN-3 is a potent thiazole-based ChemR23 inhibitor with an IC₈₀ value of 12 nM.

4-Methyl-5-thiazoleethanol	Endogenous Metabolite	Infection
4-Methyl-5-thiazoleethanol, a natural sulfur-containing flavor compound, is a thiazole precursor .

AChE-IN-44	Cholinesterase (ChE)	Neurological Disease
AChE-IN-44 (Compound Tap4) is an AChE inhibitor. AChE-IN-44 can be converted into the thiazole salt AChE inhibitor Tat2 .

β-Catenin modulator-2	β-catenin	Cancer
β-Catenin modulator-2 (compound IIa-130), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

β-Catenin modulator-3	β-catenin	Cancer
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

β-Catenin modulator-5	β-catenin	Cancer
β-Catenin modulator-5 (compound IIa-84), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

β-Catenin modulator-4	β-catenin	Cancer
β-Catenin modulator-4 (compound IIa-92), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

HY-B0990

Thiostrepton 10+ Cited Publications	Bacterial Antibiotic	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

HY-153846

RNA Aptamer Mango I sodium	Others	Others
RNA Aptamer Mango Ⅰ (sodium) consists of 39 nucleotides and has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore). RNA Aptamer Mango Ⅰ (sodium) can be used to visualize RNA expression or localization in live cells.

HY-W015695R

4-Methyl-5-thiazoleethanol (Standard)	Endogenous Metabolite	Infection
4-Methyl-5-thiazoleethanol (Standard) is the analytical standard of 4-Methyl-5-thiazoleethanol. This product is intended for research and analytical applications. 4-Methyl-5-thiazoleethanol, a natural sulfur-containing flavor compound, is a thiazole precursor .

HY-153847

RNA Aptamer Mango ΙΙ sodium	Others	Others
RNA Aptamer Mango Ⅱ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅱ (sodium) has markedly improved fluorescent properties, binding affinities, and salt dependencies.

HY-153848

RNA Aptamer Mango Ⅳ sodium	Others	Others
RNA Aptamer Mango Ⅳ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅳ has markedly improved fluorescent properties, binding affinities, and salt dependencies.

HY-153849

RNA Aptamer Mango Ⅲ sodium	Others	Others
RNA Aptamer Mango Ⅲ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅲ has markedly improved fluorescent properties, binding affinities, and salt dependencies.

HY-101511

TTT-28	P-glycoprotein	Cancer
TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1 .

HY-148134

5-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .

HY-147948

DNA Gyrase-IN-4	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC₅₀ of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively .

HY-147818

DNA Gyrase-IN-2	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .

HY-147819

DNA Gyrase-IN-3	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-3 (Compound 28) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity .

HY-113752

MMV019313	Parasite	Infection
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC₅₀ of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .

HY-146122

ATX inhibitor 19

Phosphodiesterase (PDE) Cancer

ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 156 nM .

ATX inhibitor 19	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 156 nM .

HY-151158

EGFR/HER2-IN-7	EGFR	Cancer
EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC₅₀s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC₅₀=0.907 μM) .

HY-151154

EGFR/HER2/DHFR-IN-1	EGFR	Cancer
EGFR/HER2/DHFR-IN-1 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2/DHFR-IN-1 is a multiple inhibitor of EGFR/HER2 kinase and DHFR, with IC₅₀s of 0.153 μM, 0.108 μM, 0.291 μM, respectively. EGFR/HER2/DHFR-IN-1 arrests cell cycle at G1/S and induces cells apoptosis .

HY-155372

α-Glucosidase-IN-39	Glucosidase	Metabolic Disease
α-Glucosidase-IN-39 is a potent inhibitor of α-glucosidase enzyme with an IC₅₀ of 869.06 ppm. α-Glucosidase-IN-39 can used in study antidiabetic .

HY-151161

EGFR/HER2-IN-8	EGFR	Cancer
EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC₅₀s of 0.45, 0.244 and 5.669 μM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer .

HY-151156

EGFR/HER2-IN-6	EGFR Apoptosis	Cancer
EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC₅₀s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer .

HY-146124

ATX inhibitor 21

Phosphodiesterase (PDE) Cancer

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM .

ATX inhibitor 21	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM .

HY-D0996

LDS-751	DNA Stain	Others
Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751 .

HY-147514

Anticancer agent 64	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC₅₀ of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization .

HY-146123

ATX inhibitor 20

Phosphodiesterase (PDE) Cancer

ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM .

ATX inhibitor 20	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM .

Thiazole Orange 1 Publications Verification	Fluorescent Dyes/Probes
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange can be used for reticulocyte analysis. λEx/λEm (including DNA) of Thiazole Orange =510/527 nm .

LDS-751	DNA Stain
Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751 .

Thiazole-5-carboxyaldehyde Thiazole-5-carboxaldehyde; 5-FormylThiazole	Biochemical Assay Reagents
Thiazole-5-carboxyaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

6-Bromobenzo[d]thiazole	Biochemical Assay Reagents
6-Bromobenzo[d]thiazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Thiostrepton 10+ Cited Publications	Bacterial Antibiotic	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

4-Methyl-5-thiazoleethanol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Methyl-5-thiazoleethanol, a natural sulfur-containing flavor compound, is a thiazole precursor .

Thiostrepton 10+ Cited Publications	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .

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Thiazole

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products