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Toll

" in MedChemExpress (MCE) Product Catalog:

160

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12

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Cat. No. Compare Product Name Species Source
  • HY-P73586
    TLR4 Protein, Human (sf9, His)
    1 Publications Verification

    CD284; hToll; TLR-4; Toll like receptor 4 protein; Toll

    		 Human Sf9 insect cells
    TLR4 is a transmembrane receptor that recognizes PAMPs and DAMPs and cooperates with LY96 for LPS detection. TLR4 activates MYD88-dependent and independent signaling pathways and participates in TIRAP, TRAF6 and CD14-mediated endocytosis. TLR4 Protein, Human (sf9, His) is the recombinant human-derived TLR4 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR4 Protein, Human (sf9, His) is 608 a.a., with molecular weight of ~68 kDa.
  • HY-P71373
    TOLLIP Protein, Human (His)

    Toll-Interacting Protein; TollIP

    		 Human E. coli
    TOLLIP plays a key role in IL-1 and Toll-like receptor signaling, recruiting IRAK1 to the IL-1 receptor complex and inhibiting IRAK1 phosphorylation. It connects the ubiquitin pathway to autophagy, serving as a ubiquitin-ATG8 linker for autophagic clearance of ubiquitin conjugates. TOLLIP Protein, Human (His) is the recombinant human-derived TOLLIP protein, expressed by E. coli , with C-6*His labeled tag. The total length of TOLLIP Protein, Human (His) is 273 a.a., with molecular weight of ~31.0 kDa.
  • HY-P72270
    Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His)

    CD288; CD288 antigen; Toll like receptor 8

    		 Human P. pastoris
    The TLR8 protein is an endosomal receptor critical for innate and adaptive immunity. Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His) is the recombinant human-derived Toll-like receptor 8/TLR8 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His) is 801 a.a., with molecular weight of ~93.5 kDa.
  • HY-P73587
    TLR3 Protein, Mouse (sf9, His)

    Toll-like receptor 3; CD283; Tlr3

    		 Mouse Sf9 insect cells
    TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (sf9, His) is the recombinant mouse-derived TLR3 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TLR3 Protein, Mouse (sf9, His) is 677 a.a., with molecular weight of 75-80 kDa.
  • HY-P73589
    TLR2 Protein, Rat (sf9, His)

    CD282; TIL4; TLR2; Toll-like receptor 2

    		 Rat Sf9 insect cells
    TLR2 Protein cooperates with LY96 to initiate innate immune response against bacterial lipoproteins and microbial cell wall components. It also cooperates with TLR1 or TLR6 for the immune response to bacterial lipoproteins or lipopeptides. This involves NF-kappa-B activation, cytokine secretion, and induction of inflammatory response via MYD88 and TRAF6 signaling pathways. TLR2 Protein, Rat (sf9, His) is the recombinant rat-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR2 Protein, Rat (sf9, His) is 587 a.a., with molecular weight of ~60 kDa.
  • HY-P73590
    TLR2 Protein, Mouse (sf9, His)

    CD282; TIL4; TLR2; Toll-like receptor 2

    		 Mouse Sf9 insect cells
    The TLR2 protein cooperates with LY96 to initiate an immune response against bacterial lipoproteins and cell wall components. It cooperates with TLR1 or TLR6 to activate NF-kappa-B, induce cytokine secretion, and form activation clusters such as TLR2:TLR6:CD14:CD36. TLR2 Protein, Mouse (sf9, His) is the recombinant mouse-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR2 Protein, Mouse (sf9, His) is 587 a.a., with molecular weight of ~65 kDa.
  • HY-P73591
    TLR2 Protein, Human (sf9, His)

    CD282; TIL4; TLR2; Toll-like receptor 2

    		 Human Sf9 insect cells
    TLR2 is a protein that plays a critical role in recognizing and responding to various bacterial and mycobacterial pathogens. TLR2 Protein, Human (sf9, His) is the recombinant human-derived TLR2 protein, expressed by Sf9 insect cells , with C-10*His labeled tag. The total length of TLR2 Protein, Human (sf9, His) is 567 a.a., with molecular weight of ~65.5 kDa.
  • HY-P73588
    TLR3 Protein, Mouse (705a.a, HEK293, His)

    Toll-like receptor 3; CD283; Tlr3

    		 Mouse HEK293
    TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (705a.a, HEK293, His) is the recombinant mouse-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TLR3 Protein, Mouse (705a.a, HEK293, His) is 705 a.a., with molecular weight of 100-110 kDa.
  • HY-P74547
    SIGIRR Protein, Mouse (HEK293, His)

    Single Ig IL-1-related receptor; Toll/interleukin-1 receptor 8; TIR8

    		 Mouse HEK293
    SIGIRR protein negatively regulates the Toll-like pathway and IL-1R pathway by inhibiting the recruitment of TLR4. SIGIRR disrupts Il1R1 and IL1RAP heterodimerization through its extracellular domain. SIGIRR Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived SIGIRR protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of SIGIRR Protein, Mouse (HEK293, His-hFc) is 117 a.a., with molecular weight of 60-65 kDa.
  • HY-P76064
    SIGIRR Protein, Human (HEK293, Fc)

    Single Ig IL-1-related receptor; Toll/interleukin-1 receptor 8; TIR8

    		 Human HEK293
    SIGIRR Protein functions as a negative regulator of Toll-like and IL-1R receptor signaling pathways. It inhibits recruitment of signaling components to TLR4 receptor through TIR domain interaction. SIGIRR also hinders heterodimerization of Il1R1 and IL1RAP via its extracellular domain. It interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, TRAF6, and PALM3. Upon IL-1 stimulation, SIGIRR forms complex with IL1R1, SIGIRR, MYD88, IRAK1, and TRAF6. Similarly, upon LPC stimulation, SIGIRR is part of complex including TLR4, SIGIRR, MYD88, IRAK1, and TRAF6. SIGIRR Protein, Human (HEK293, Fc) is the recombinant human-derived SIGIRR protein, expressed by HEK293, with C-hFc labeled tag. The total length of SIGIRR Protein, Human (HEK293, Fc) is 118 a.a., with molecular weight of 50-70 kDa.
  • HY-P76065
    SIGIRR Protein, Human (HEK293, His)

    Single Ig IL-1-related receptor; Toll/interleukin-1 receptor 8; TIR8

    		 Human HEK293
    SIGIRR Protein functions as a negative regulator of Toll-like and IL-1R receptor signaling pathways. It inhibits recruitment of signaling components to TLR4 receptor through TIR domain interaction. SIGIRR also hinders heterodimerization of Il1R1 and IL1RAP via its extracellular domain. It interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, TRAF6, and PALM3. Upon IL-1 stimulation, SIGIRR forms complex with IL1R1, SIGIRR, MYD88, IRAK1, and TRAF6. Similarly, upon LPC stimulation, SIGIRR is part of complex including TLR4, SIGIRR, MYD88, IRAK1, and TRAF6. SIGIRR Protein, Human (HEK293, His) is the recombinant human-derived SIGIRR protein, expressed by HEK293, with C-His labeled tag. The total length of SIGIRR Protein, Human (HEK293, His) is 118 a.a., with molecular weight of ~22-35 kDa.
  • HY-P76311
    ECSIT Protein, Human (His)

    Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Protein SITPEC; ECSIT

    		 Human E. coli
    ECSIT protein is an adapter protein in Toll-like receptors, IL-1, and antiviral signaling that crucially activates NF-kappa-B by complexing with TRAF6 and TAK1/MAP3K7, leading to TAK1/MAP3K7 activation and subsequent IKK activation. Ubiquitinated ECSIT interacts with RELA and NFKB1 and translocates to induce NF-kappa-B-dependent gene expression. ECSIT Protein, Human (His) is the recombinant human-derived ECSIT protein, expressed by E. coli , with N-His labeled tag. The total length of ECSIT Protein, Human (His) is 186 a.a., with molecular weight of ~25 KDa.

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