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Isoforms Recommended:	TrkB

Results for "

TrkB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adrenergic Receptor (4) Akt (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (3) c-Kit (2) Discoidin Domain Receptor (2) EGFR (1) Endogenous Metabolite (3) ERK (1) FGFR (1) FLT3 (3) Histamine Receptor (4) IGF-1R (1) Insulin Receptor (1) JAK (1) mAChR (4) RIP kinase (1) Serotonin Transporter (4) Sodium Channel (4) Trk Receptor (29) VEGFR (3)
By Research Areas:	Cancer (16) Endocrinology (1) Inflammation/Immunology (2) Neurological Disease (19)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective *TrkB* inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced *TrkB* activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-153189

TrkB-IN-1	Trk Receptor	Neurological Disease
TrkB-IN-1 is a potent and orally active *TrkB* agonist and has favorable PK properties. TrkB-IN-1 reverses the cognitive defects in an AD mouse model and can be used for alzheimer’s disease research .

HY-152472

ENT-C225	Trk Receptor	Neurological Disease
ENT-C225 is an effective activator of *TrkB* neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties .

HY-12327

Trk-IN-1	Trk Receptor	Neurological Disease Cancer
Trk-IN-1 (example 9), a potent tropomyosin-related kinase (Trk) inhibitor, shows potency against TrkA (3.7 nM) and TrkB (94 nM), respectively .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective *TrkB* inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced *TrkB* activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-137465

CG428	Trk Receptor	Cancer
CG428 is a potent and selective tropomyosin receptor kinase (TRK) degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 (TPM3)-TRKA fusion protein in KM12 colorectal carcinoma cells (DC₅₀ = 0.36 nM) and inhibits downstream PLCγ1phosphorylation (IC₅₀ = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (K_d = 1 nM, 28 nM and 4.2 nM, respectively). In addition, CG428 effectively inhibits KM12 cell growth (IC₅₀ = 2.9 nM) .

HY-104047

LM22B-10 10+ Cited Publications	Trk Receptor Akt ERK	Neurological Disease
LM22B-10 is an activator of *TrkB/TrkC* neurotrophin receptor, and can induce *TrkB, TrkC, AKT* and ERK activation in vitro and in vivo.

HY-16961

Sitravatinib 1 Publications Verification MGCD516; MG-516	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-16961A

Sitravatinib malate MGCD516 malate; MG-516 malate	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-107854

N-Acetyl-5-hydroxytryptamine 2 Publications Verification N-Acetylserotonin; Normelatonin; O-Demethylmelatonin	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate *TrkB* receptor.

HY-17603

Belizatinib 1 Publications Verification TSR-011	Anaplastic lymphoma kinase (ALK) Trk Receptor	Cancer
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC₅₀ of 0.7 nM for wild-type recombinant ALK kinase.

HY-101446

HIOC
HIOC is a potent and selective activator of *TrkB* (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates *TrkB/ERK* pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration .

HY-12497

ANA-12 Maximum Cited Publications 26 Publications Verification	Trk Receptor	Neurological Disease
ANA-12 is a potent and selective *TrkB* antagonist with IC₅₀s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.

HY-W013372

7,8-Dihydroxyflavone 10+ Cited Publications	Trk Receptor Apoptosis	Neurological Disease
7,8-Dihydroxyflavone is a potent and selective *TrkB* agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .

HY-112437

PF-06737007	Trk Receptor	Neurological Disease
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC₅₀s of 7.7 nM, 15 nM and 3.9 nM for TrkA, *TrkB* and TrkC, respectively . Anti-hyperalgesic effect .

HY-112434

PF-06733804	Trk Receptor	Neurological Disease
PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC₅₀s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, *TrkB* and TrkC, respectively . Anti-hyperalgesic effect .

HY-13034

Gandotinib 3 Publications Verification LY2784544	JAK FLT3 FGFR VEGFR	Cancer
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC₅₀ of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC₅₀ of 4, 25, 32, 44, and 95 nM.

HY-112436

PF-6683324 Trk-IN-4	Trk Receptor	Neurological Disease
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC₅₀s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, *TrkB* and TrkC, respectively . Anti-hyperalgesic effect .

HY-15590

AZ-23 3 Publications Verification AZ23; AZ 23	Trk Receptor	Cancer
AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC₅₀s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.

HY-107854S

N-Acetyl-5-hydroxytryptamine-d3 N-Acetylserotonin-d₃; Normelatonin-d₃; O-Demethylmelatonin-d₃	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine-d₃ is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].

HY-151948

TrkA-IN-3	Trk Receptor	Neurological Disease
TrkA-IN-3 is a potent, subselective and allosteric TrkA inhibitor, with an IC₅₀ of 22.4 nM. TrkA-IN-3 shows more than 8000-fold selectivity for TrkA over TrkB and TrkC. TrkA-IN-3 can be used for the research of pain .

HY-107854R

N-Acetyl-5-hydroxytryptamine (Standard) N-Acetylserotonin (Standard); Normelatonin (Standard); O-Demethylmelatonin (Standard)	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate *TrkB* receptor.

HY-163366

TRK-IN-28	Trk Receptor	Cancer
TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK ^WT, TRK ^G595R and TRK ^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA ^WT, Ba/F3-ETV6-TRKB ^WT, Ba/F3-LMNA-TRK ^G595R and Ba/F3-LMNA-TRKA ^G667C, respectively .

HY-13491

GNF-5837 3 Publications Verification	Trk Receptor	Cancer
GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC₅₀ values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, *Tel-TrkB* and Tel-TrkA, respectively) .

HY-119933

RIPK1-IN-7	RIP kinase	Cancer
RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K_d of 4 nM and an enzymatic IC₅₀ of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model .

HY-10200

BMS-754807 5+ Cited Publications	IGF-1R Insulin Receptor	Endocrinology Cancer
BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively .

HY-20878

Tyrphostin AG 879 1 Publications Verification AG 879	Trk Receptor EGFR Apoptosis	Cancer
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity .

HY-B0527A

Amitriptyline hydrochloride 3 Publications Verification	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease Cancer
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and *TrkB* receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

HY-144069

Pan-Trk-IN-3	Trk Receptor Apoptosis	Cancer
Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC₅₀ values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, *TrkB, TrkC, TrkA ^G595R, TrkA ^G667C, TrkA ^G667S, TrkA ^F589L* and TrkC ^G623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis .

HY-B0527AS

Amitriptyline-d6 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-135096

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and *TrkB* receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

HY-143557

Trk-IN-7	Trk Receptor	Cancer
Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC₅₀s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC₅₀<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC₅₀=5-50 nM) .

HY-B0527AR

Amitriptyline hydrochloride (Standard)	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease Cancer
Amitriptyline (hydrochloride) (Standard) is the analytical standard of Amitriptyline (hydrochloride). This product is intended for research and analytical applications. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and *TrkB* receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

Cat. No.	Product Name	Target	Research Area

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective *TrkB* inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced *TrkB* activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective *TrkB* inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced *TrkB* activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

N-Acetyl-5-hydroxytryptamine 2 Publications Verification N-Acetylserotonin; Normelatonin; O-Demethylmelatonin	Alkaloids Monophenols Source classification Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite Trk Receptor
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate *TrkB* receptor.

7,8-Dihydroxyflavone 10+ Cited Publications	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Plants Umbelliferae Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Trk Receptor Apoptosis
7,8-Dihydroxyflavone is a potent and selective *TrkB* agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .

N-Acetyl-5-hydroxytryptamine (Standard) N-Acetylserotonin (Standard); Normelatonin (Standard); O-Demethylmelatonin (Standard)	Alkaloids Structural Classification Monophenols Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite Trk Receptor
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate *TrkB* receptor.

Recombinant Proteins Recommended:

TrkB

Species:	Human (3) Rat (3) Mouse (2) Canine (2)
Tag:	His (7) Flag (1) Fc (3)
Source:	HEK293 (9) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73461

	TrkB Protein, Canine (HEK293, His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, His) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Canine (HEK293, His) is 399 a.a., with molecular weight of ~60-78 kDa.

HY-P73574

	TrkB Protein, Rat (HEK293, His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, His) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Rat (HEK293, His) is 398 a.a., with molecular weight of ~67 kDa.

HY-P702763

	*NTRK2/TrkB* Protein, Human (Biotinylated, sf9, Flag)** NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; trk-B; GP145-TrkB/GP95-TrkB; TrkB tyrosine kinase; Neural receptor protein-tyrosine kinase (TrkB); Tkrb; TrkB; TrkB1; RATTrkB1	Human	Sf9 insect cells

HY-P73575

	TrkB Protein, Rat (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkB Protein, Rat (HEK293, Fc) is 429 a.a., with molecular weight of ~120 kDa.

HY-P73576

	TrkB Protein, Canine (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkB Protein, Canine (HEK293, Fc) is 430 a.a., with molecular weight of ~71.2 kDa.

HY-P73462

	TrkB Protein, Human (HEK293, His-Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-hFc, C-His, C-10*His labeled tag. The total length of TrkB Protein, Human (HEK293, His-Fc) is 399 a.a., with molecular weight of 95-130 kDa.

HY-P70793

	TrkB Protein, Human (HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B; NTRK2; TrkB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TrkB Protein, Human (HEK293, His) is 399 a.a., with molecular weight of 60-105 kDa.

HY-P73463

	TrkB Protein, Mouse (429a.a, HEK293, His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (429a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (429a.a, HEK293, His) is 429 a.a., with molecular weight of 75-85 kDa.

HY-P72436

	TrkB Protein, Mouse (398a.a, HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; NTRK2; TrkB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (398a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (398a.a, HEK293, His) is 398 a.a., with molecular weight of 60-90 kDa.

HY-P73574A

	TrkB Protein, Rat (HEK293, C-His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TrkB	Rat	HEK293
	TrkB, a pivotal receptor tyrosine kinase, orchestrates diverse neuronal processes in the central and peripheral nervous systems. Serving as a receptor for BDNF and NTF4, it modulates survival through NTF3. Upon ligand binding, TrkB undergoes activation, initiating downstream cascades. It recruits effectors like SHC1, FRS2, SH2B1, SH2B2, and PLCG1, regulating pathways for differentiation, growth, survival, and synaptic plasticity. TrkB's role in learning involves short-term synaptic function, long-term potentiation, and PLCG1-mediated suppression of anoikis. Additionally, it contributes to neurotrophin-dependent calcium signaling in glial cells. TrkB Protein, Rat (HEK293, C-His) is the recombinant rat-derived TrkB protein, expressed by HEK293, with C-6*His labeled tag. The total length of TrkB Protein, Rat (HEK293, C-His) is 398 a.a., with molecular weight of ~62-85 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80862

Phospho-TrkA/B (Tyr490/Tyr516) Antibody NTRK2; TrkB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B	WB	Human, Mouse, Rat
Phospho-TrkA/B (Tyr490/Tyr516) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to Phospho-TrkA/B (Tyr490/Tyr516). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80360

TrkB Antibody	WB, IHC-P	Mouse, Rat
TrkB Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to TrkB. It can be used for WB,IHC-P assays with tag free, in the background of Mouse, Rat.

HY-P80923

Trk B Antibody TrkB	WB	Rat
Trk B Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to Trk B. It can be used for WB assays with tag free, in the background of Rat.

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TrkB

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