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Results for "

U251

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (3) Apoptosis (4) ATM/ATR (1) Autophagy (4) Biochemical Assay Reagents (1) c-Fms (1) CDK (1) Chloride Channel (2) DGK (1) DNA-PK (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug-Linker Conjugates for ADC (1) Ephrin Receptor (2) ERK (1) Fluorescent Dye (1) Furin (2) HSP (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Mixed Lineage Kinase (1) Monoamine Oxidase (1) Mps1 (1) Necroptosis (2) NF-κB (1) Oct3/4 (1) PKA (2) PKC (2) Ribosomal S6 Kinase (RSK) (2) RIP kinase (1) ROCK (2) SGK (2) Topoisomerase (5)
By Research Areas:	Cancer (34) Infection (2) Metabolic Disease (1) Neurological Disease (3)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Akt (3)

Apoptosis (4)

ATM/ATR (1)

Autophagy (4)

Biochemical Assay Reagents (1)

c-Fms (1)

CDK (1)

Chloride Channel (2)

DGK (1)

DNA-PK (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug-Linker Conjugates for ADC (1)

Ephrin Receptor (2)

ERK (1)

Fluorescent Dye (1)

Furin (2)

HSP (1)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Mixed Lineage Kinase (1)

Monoamine Oxidase (1)

Mps1 (1)

Necroptosis (2)

NF-κB (1)

Oct3/4 (1)

PKA (2)

PKC (2)

Ribosomal S6 Kinase (RSK) (2)

RIP kinase (1)

ROCK (2)

SGK (2)

Topoisomerase (5)

By Research Areas:

Cancer (34)

Infection (2)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-156418

KY386	DNA/RNA Synthesis	Cancer
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC₅₀ of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC₅₀ of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .

HY-N10871

Neocryptomerin

Others Cancer

Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

Neocryptomerin	Others	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

HY-129932

Pyrrolidine ricinoleamide	Others	Cancer
Pyrrolidine ricinoleamide ((R)-5d) is a fatty acid amide that exhibits effective antiproliferative activity against a series of cancer cells, including human glioma U251 cells. Pyrrolidine ricinoleamide can be used in cancer research .

HY-13768S1

Topotecan-d6	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87[1][2].

HY-155532

10m/ZS44	Biochemical Assay Reagents	Cancer
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Others	Cancer
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-147637

EphA2 agonist 1	Ephrin Receptor	Cancer
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation .

HY-144828

RIP1/RIP3/MLKL activator 1	RIP kinase Mixed Lineage Kinase Necroptosis	Cancer
RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability .

HY-146141

EphA2 agonist 2

Ephrin Receptor Cancer

EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB .
HY-162002

WSD0628

ATM/ATR Cancer

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect .

EphA2 agonist 2	Ephrin Receptor	Cancer
EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB .

WSD0628	ATM/ATR	Cancer
WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect .

HY-124242

(S)-α-Methylbenzyl ricinoleamide	Others	Cancer
(S)-α-Methylbenzyl ricinoleamide (compound (R,S)-3d) is a fatty acid amide. (S)-α-Methylbenzyl ricinoleamide shows antiproliferative activity .

HY-163385

ALKBH1-IN-1	Others	Cancer
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC₅₀ of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA .

HY-13768

Topotecan SKF 104864A; NSC 609669	Topoisomerase Autophagy Apoptosis	Cancer
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .

HY-B0380A

Trimebutine maleate	Oct3/4 ERK Akt Apoptosis	Metabolic Disease Cancer
Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome .

HY-13768C

Topotecan hydrochloride hydrate SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate	Topoisomerase Apoptosis Autophagy	Cancer
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .

HY-N9292

Friedelin-3,4-lactone

Others Cancer

Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .

Friedelin-3,4-lactone	Others	Cancer
Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .

HY-12768B

Sotuletinib dihydrochloride BLZ945 dihydrochloride	c-Fms	Neurological Disease Cancer
Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC₅₀=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research .

HY-163290

HDAC-MB	Fluorescent Dye Monoamine Oxidase	Cancer
HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis .

HY-154988

MARK4 inhibitor 4	Others	Neurological Disease Cancer
MARK4 inhibitor 4 is a MARK4 inhibitor with an IC₅₀ of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .

HY-12401A

Mps1-IN-3 hydrochloride 1 Publications Verification	Mps1	Cancer
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC₅₀ value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model .

HY-148174

JNJ-3790339	DGK	Cancer
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC₅₀ of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation .

HY-110147A

SSM3 tetraTFA	Furin	Infection
SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

HY-146320

ANO1-IN-1	Chloride Channel	Cancer
ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC₅₀ of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells .

HY-146321

ANO1-IN-2	Chloride Channel	Cancer
ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC₅₀ of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells .

HY-110147B

SSM3 tetraTFA hydrate	Furin	Infection
SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

HY-160649

MC-Gly-Gly-Phe-Gly-GABA-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC₅₀ of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo .

HY-161385

Topoisomerase I inhibitor 16	Topoisomerase	Cancer
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI₅₀ 39 nM .

HY-19939S

VX-984 4 Publications Verification M9831	DNA-PK	Cancer
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals .

HY-113916

Onalespib lactate AT13387 lactate	HSP	Cancer
Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an K_d value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-116107

AG311

Necroptosis Cancer

AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

AG311	Necroptosis	Cancer
AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

HY-132302

Hu7691	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

HY-132302A

Hu7691 free base	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 free base is an orally active, selective Akt inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice .

HY-147409

Ulecaciclib	CDK	Cancer
Ulecaciclib is an orally activitive inhibitor of cyclin-dependent kinase (CDK), with K_i values of 0.62 μM (CDK2/Cyclin A), 0.2 nM (CDK4/Cyclin D1), 3 nM (CDK6/Cyclin D3), and 0.63 μM (CDK7/Cyclin H), respectively. Ulecaciclib can cross blood brain barrier and has good pharmacokinetic characteristics .

HY-14543

Sertindole 2 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N10871

Neocryptomerin	Structural Classification Flavonoids Source classification Taxodiaceae Plants Cunninghamia lanceolata var. konishii Biflavones	Others
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-N9292

Friedelin-3,4-lactone	Triterpenes Structural Classification Terpenoids Source classification Euphorbiaceae Plants Garcia parviflora Lundell	Others
Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .

Cat. No.	Product Name	Chemical Structure

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87[1][2].

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