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Results for "

UCB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (1) AMPK (1) Calcium Channel (2) CCR (1) Dan family (1) DNA Methyltransferase (4) Drug Derivative (2) GABA Receptor (4) Glutaminase (1) Histamine Receptor (6) HIV (1) iGluR (4) Integrin (2) Interleukin Related (3) Isotope-Labeled Compounds (5) JAK (1) Lipoxygenase (1) MHC (1) Parasite (3) PI3K (2) PI4K (1) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (9) Synaptic Vesicle Proteins (5) Tau Protein (1) TNF Receptor (4) α-synuclein (3)
By Research Areas:	Cancer (8) Endocrinology (5) Infection (3) Inflammation/Immunology (18) Metabolic Disease (1) Neurological Disease (30)

By Targets:

Adenylate Cyclase (1)

AMPK (1)

Calcium Channel (2)

CCR (1)

Dan family (1)

DNA Methyltransferase (4)

Drug Derivative (2)

GABA Receptor (4)

Glutaminase (1)

Histamine Receptor (6)

HIV (1)

iGluR (4)

Integrin (2)

Interleukin Related (3)

Isotope-Labeled Compounds (5)

JAK (1)

Lipoxygenase (1)

MHC (1)

Parasite (3)

PI3K (2)

PI4K (1)

Radionuclide-Drug Conjugates (RDCs) (1)

Reference Standards (9)

Synaptic Vesicle Proteins (5)

Tau Protein (1)

TNF Receptor (4)

α-synuclein (3)

By Research Areas:

Cancer (8)

Endocrinology (5)

Infection (3)

Inflammation/Immunology (18)

Metabolic Disease (1)

Neurological Disease (30)

Inhibitors & Agonists

Inhibitory Antibodies

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99280

Bimekizumab 1 Publications Verification CDP4940; UCB-4940	Interleukin Related	Inflammation/Immunology
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation .

HY-B0106

Levetiracetam 2 Publications Verification UCB L059	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-133122

UCB-9260 3 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar K_d of 13 nM .

HY-P99643

Ginisortamab UCB6114	Dan family	Cancer
Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC₅₀ values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors .

HY-B0585

Piracetam 1 Publications Verification UCB-6215	iGluR	Neurological Disease
Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

HY-P9979

Rozanolixizumab 1 Publications Verification UCB7665	TNF Receptor	Inflammation/Immunology
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases .

HY-P99471

Bepranemab UCB 0107	Tau Protein	Neurological Disease
Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease .

HY-156454

UCB-6876	TNF Receptor	Inflammation/Immunology
UCB-6876 is a TNFα inhibitor. UCB-6876 specifically binds to the asymmetric crystalline form of TNF-α trimer with a K_D of 22 μM. UCB-6876 is applicable to research related to autoimmune diseases (rheumatoid arthritis and Crohn's disease) .

HY-109009

Padsevonil 2 Publications Verification UCB-0942	GABA Receptor	Neurological Disease
Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABA_AR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models .

HY-B0106A

Etiracetam UCB 6474	Drug Derivative	Neurological Disease
Etiracetam is a racetam-class nootropic agent. Etiracetam enhances learning and memory in both normal and amnesic rats. Etiracetam can be used in studies related to memory retrieval disorders and amnesic diseases such as Alzheimer's disease .

HY-P99512

Zampilimab UCB-7858	Glutaminase	Endocrinology
Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab inhibits TG2 crosslinking transamidation activity with an IC₅₀ of 0.25 nM and a K_d of <50 pM. Zampilimab improves renal fibrosis .

HY-112613

UCB9608 1 Publications Verification	PI4K	Inflammation/Immunology
UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC₅₀ of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent .

HY-145580

Minzasolmin UCB0599; (R)-NPT200-11	α-synuclein	Neurological Disease
Minzasolmin (UCB0599; (R)-NPT200-11) is an orally active, blood-brain-permeable α-synuclein (α-Syn) inhibitor that selectively binds to α-Syn misfolded intermediates (such as oligomers) and inhibits aggregation and fibril formation by regulating their conformational stability. Minzasolmin can reduce the generation of pathological oligomers and block neurotoxic signaling, thereby reducing the abnormal accumulation of α-Syn in the brain. Minzasolmin significantly improved motor deficits, reduced neuroinflammatory markers, and α-Syn-related pathological deposition in transgenic mouse models .

HY-75385

Zaurategrast ethyl ester CDP323; UCB1184197	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758 , is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders .

HY-147045

UCB-5307	TNF Receptor	Inflammation/Immunology
UCB-5307 is a potent TNF signaling inhibitor with a K_D of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex .

HY-16754

Seletalisib 2 Publications Verification UCB5857	PI3K	Inflammation/Immunology
Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC₅₀ of 12 nM.

HY-B1032

Dropropizine (±)-Dropropizine; UCB-196	Histamine Receptor	Neurological Disease
Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .

HY-P990741

Galvokimig UCB-9741	Interleukin Related	Inflammation/Immunology
Galvokimig is an anti-IL13/IL17A/ALB/IL17B monoclonal antibody .

HY-167830

SDM-8	Radionuclide-Drug Conjugates (RDCs)	Neurological Disease
SDM-8 is a difluoro-analog of UCB-J (HY-136873).SDM-8 shows high SV2A binding affinity with a K_i of 0.58 nM. SDM-8 can be used in the study of Alzheimer's disease .

HY-119810

Seletracetam 1 Publications Verification UCB 44212	Synaptic Vesicle Proteins	Neurological Disease
Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy .

HY-125287

(Rac)-Minzasolmin (Rac)-UCB0599; NPT200-11	α-synuclein	Neurological Disease
(Rac)-Minzasolmin ((Rac)-UCB0599; NPT200-11) is a blood-brain barrier penetrated alpha-synuclein (ASYN) misfolding inhibitor. (Rac)-Minzasolmin acts on the early stage of ASYN aggregation process, by replacing the membrane-bound oligomers ASYN, allowing them to revert to the monomeric form, while preventing pathological aggregation. (Rac)-Minzasolmin effectively improves the ASYN deposition in the retina and the neuro-pathological indicators in two α-synuclein transgenic mouse models. (Rac)-Minzasolmin can be used for the studies of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) .

HY-A0075

Decloxizine dihydrochloride 1 Publications Verification UCB 1402 dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Decloxizine dihydrochloride(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.

HY-P99417

Abrezekimab UCB4144; VR 942	Interleukin Related	Inflammation/Immunology
Abrezekimab (UCB4144; VR 942) is a humanized, high-affinity, neutralizing anti-human-IL-13 antibody fragment that binds to IL-13. Abrezekimab prevents IL-13 binding to the IL-13 Rα1 subunit. Abrezekimab can be used for the research of asthma .

HY-B0106R

Levetiracetam (Standard) UCB L059 (Standard)	Reference Standards DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-145580A

(S)-Minzasolmin (S)-UCB0599; (S)-NPT200-11	α-synuclein	Neurological Disease
(S)-Minzasolmin is an isomer of minzasolmin (HY-145580), an inhibitor of α-synuclein oligomerization .

HY-19443

UCB-35440	Histamine Receptor Lipoxygenase	Inflammation/Immunology
UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 can be used for the research of dermatologic inflammatory conditions .

HY-170360

UCB9386	AMPK JAK	Cancer
UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC₅₀ of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM .

HY-136873

UCB-J	Synaptic Vesicle Proteins	Neurological Disease
UCB-J is a ligand for synaptic vesicle protein 2A (SV2A) with pIC₅₀ values for human and rat SV2A of 8.15 and 7.6 respectively. UCB-J can be used to display and quantify the total synaptic density throughout the brain .

HY-109009A

(S)-Padsevonil (S)-UCB-0942	GABA Receptor	Neurological Disease
(S)-Padsevonil is the S-enantiomer of Padsevonil (HY-109009).Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABA_AR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models .

HY-B1032R

Dropropizine (Standard) (±)-Dropropizine (Standard); UCB-196 (Standard)	Others Reference Standards	Neurological Disease
Dropropizine (Standard) is the analytical standard of Dropropizine. This product is intended for research and analytical applications. Dropropizine ((±)-Dropropizine) is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .

HY-B0106S

Levetiracetam-d6 UCB L059-d₆	Isotope-Labeled Compounds DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-110225

Levetiracetam-d6 (ring-d6) UCB L059-d6 (ring-d6)	Others	Others
Levetiracetam-d6 (ring-d6) can be used as internal standard for the determination of Levetiracetam (HY-B0106) content in whole blood .

HY-17582

Decloxizine 1 Publications Verification UCB-1402; NSC289116	Histamine Receptor	Inflammation/Immunology Endocrinology
Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.

HY-75385A

Zaurategrast ethyl ester sulfate CDP323 sulfate; UCB1184197 sulfate	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758 , is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders .

HY-120547

UCB-11056	Adenylate Cyclase	Neurological Disease Metabolic Disease
UCB-11056 is a modulator of cyclic AMP generation. UCB-11056 can rapidly increase cyclic AMP levels in the rat brain in vivo and potentiate stimulated cyclic AMP formation in vitro. UCB-11056 does not stimulate cAMP formation on its own. UCB-11056 is a potential nootropic drug .

HY-151568

UCB7362	Parasite	Infection
UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth .

HY-B0106AR

Etiracetam (Standard) UCB 6474 (Standard)	Reference Standards Calcium Channel	Neurological Disease
Etiracetam (Standard) is the analytical standard of Etiracetam. This product is intended for research and analytical applications. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059) .

HY-156063

*(2R,4R)-UCB7362*	Parasite	Infection
(2R,4R)-UCB7362 is the (2R,4R) isomer of UCB7362 (HY-151568). UCB7362 is an inhibitor of plasma proteinase X (PMX) with antimalarial activity .

HY-119810A

Seletracetam lithium UCB 44212 lithium	HIV	Neurological Disease
Seletracetam (Ucb 44212) lithium, as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy .

HY-156063A

*(2R,4R)-UCB7362 hydrochloride*	Parasite	Infection
(2R,4R)-UCB7362 hydrochloride is the (2R,4R) isomer of UCB7362 (HY-151568). (2R,4R)-UCB7362 hydrochloride is an inhibitor of plasma proteinase X (PMX) with antimalarial activity .

HY-B0585R

Piracetam (Standard) 1 Publications Verification UCB-6215 (Standard)	Reference Standards iGluR	Neurological Disease
Piracetam (Standard) is the analytical standard of Piracetam. This product is intended for research and analytical applications. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

HY-119810B

Seletracetam lithium bromide UCB 44212 lithium bromide	Synaptic Vesicle Proteins	Neurological Disease
Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy .

HY-B0585S1

Piracetam-d6 UCB-6215-d₆	Isotope-Labeled Compounds iGluR	Neurological Disease
Piracetam-d₆ is deuterium labeled Piracetam. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

HY-B0106AS

Etiracetam-d3 UCB 6474-d₃	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Etiracetam-d₃ is the deuterium labeled Etiracetam. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059) .

HY-B0585S

Piracetam-d8	Isotope-Labeled Compounds iGluR	Neurological Disease
Piracetam-d₈ (UCB-6215-d₈) is the deuterium labeled Piracetam. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders .

HY-103360A

cis-J-113863 UCB35625	CCR	Inflammation/Immunology
cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC₅₀ values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively .

HY-17582R

Decloxizine (Standard) UCB-1402 (Standard); NSC289116 (Standard)	Reference Standards Histamine Receptor	Inflammation/Immunology Endocrinology
Decloxizine (Standard) is the analytical standard of Decloxizine. This product is intended for research and analytical applications. 0

HY-B0106S1

Levetiracetam-d3 UCB L059-d₃	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-W767656

Dropropizine-d4 (±)-Dropropizine-d₄; UCB-196-d₄	Isotope-Labeled Compounds Others	Neurological Disease
Dropropizine-d₄ ((±)-Dropropizine-d₄) is deuterium labeled Dropropizine. Dropropizine ((±)-Dropropizine) belongs to the phenylpiperazine group of organic compounds. Dropropizine is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .

HY-180554

UCB1244283	Synaptic Vesicle Proteins	Neurological Disease
UCB1244283 is a synaptic vesicle glycoprotein 2A (SV2A) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research .

Cat. No.	Product Name	Target	Research Area	Image