UVA

By Targets:	Akt (1) Apoptosis (4) Bacterial (1) Biochemical Assay Reagents (7) Estrogen Receptor/ERR (2) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Melanocortin Receptor (2) MMP (3) NF-κB (1) Reactive Oxygen Species (4) Tyrosinase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Inflammation/Immunology (5) Metabolic Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3925

Ganoderol A	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .

HY-W127530

α-Tocopherol phosphate disodium 3 Publications Verification alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium	Apoptosis Reactive Oxygen Species	Cardiovascular Disease
α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .

HY-16182A

Ecamsule disodium	Biochemical Assay Reagents	Others
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .

HY-109654

Ensulizole	Reactive Oxygen Species	Metabolic Disease
Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .

HY-126956

Porphyra 334	Reactive Oxygen Species MMP	Inflammation/Immunology
Porphyra 334 is an antioxidative and anti-photoaging agent. Porphyra 334 suppresses ROS production and the expression of MMPs following UVA irradiation .

HY-16182

Ecamsule	Biochemical Assay Reagents	Others
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-109656

Diethylamino hydroxybenzoyl hexyl benzoate

DHHB
Others Others

Diethylamino hydroxybenzoyl hexyl benzoate is a photostable UV-A absorber.
HY-B0966

Dioxybenzone

Benzophenone-8; UV-24
Biochemical Assay Reagents Others

Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays.

Diethylamino hydroxybenzoyl hexyl benzoate DHHB	Others	Others
Diethylamino hydroxybenzoyl hexyl benzoate is a photostable UV-A absorber.

Dioxybenzone Benzophenone-8; UV-24	Biochemical Assay Reagents	Others
Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays.

HY-B0897

Bisoctrizole 1 Publications Verification	Biochemical Assay Reagents	Others
Bisoctrizole is a broad-spectrum UV absorber that absorbs UVB and UVA rays while reflecting and scattering UV rays.

HY-B1162

Sulisobenzone Benzophenone-4	Biochemical Assay Reagents	Others
Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light.

HY-N1190

DL-Syringaresinol (±)-Syringaresinol
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-W749966

Octocrylene-d10	Isotope-Labeled Compounds	Metabolic Disease
Octocrylene-d10 is the deuterium labeled Octocrylene. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths .

HY-B0966R

Dioxybenzone (Standard) Benzophenone-8 (Standard); UV-24 (Standard)	Biochemical Assay Reagents	Others
Dioxybenzone (Standard) is the analytical standard of Dioxybenzone. This product is intended for research and analytical applications. Dioxybenzone is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation.

HY-P5252

Diaminopropionoyl tripeptide-33	Tyrosinase	Metabolic Disease
Diaminopropionoyl tripeptide-33isa bioactive peptide with protects skin cells from UVA-induced DNA damages and has been reported used as a cosmetic ingredient .

HY-B0316

Avobenzone	Estrogen Receptor/ERR Apoptosis	Others
Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist .

HY-W745164

3,3′-Bisdemethylpinoresinol	MMP	Inflammation/Immunology
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

HY-A0087

Octocrylene 2 Publications Verification	Biochemical Assay Reagents	Others
Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. Octocrylene has the potential for using in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation .

HY-109654R

Ensulizole (Standard)	Reactive Oxygen Species	Metabolic Disease
Ensulizole (Standard) is the analytical standard of Ensulizole. This product is intended for research and analytical applications. Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .

HY-B0316S

Avobenzone-13C,d3	Isotope-Labeled Compounds Estrogen Receptor/ERR Apoptosis	Others
Avobenzone- ¹³C,d₃ is the ¹³C- and deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2].

HY-P0097A

Nonapeptide-1 acetate salt 2 Publications Verification Melanostatine-5 acetate salt	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P0097

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-N1326

Santamarine Santamarin; Balchanin	Keap1-Nrf2	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Inflammation/Immunology Cancer
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

Cat. No.	Product Name	Type

HY-W127530

α-Tocopherol phosphate disodium 3 Publications Verification alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium	Biochemical Assay Reagents
α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .

α-Tocopherol phosphate disodium

3 Publications Verification

alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

Biochemical Assay Reagents

α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P0097A

Nonapeptide-1 acetate salt 2 Publications Verification Melanostatine-5 acetate salt	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P5252

Diaminopropionoyl tripeptide-33	Tyrosinase	Metabolic Disease
Diaminopropionoyl tripeptide-33isa bioactive peptide with protects skin cells from UVA-induced DNA damages and has been reported used as a cosmetic ingredient .

HY-P0097

Nonapeptide-1 Melanostatine-5	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3925

Ganoderol A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Metabolic Disease Plants Disease Research Fields Inflammation/Immunology	Bacterial
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .

HY-N3387

Licoricidin	Natural Products Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Apoptosis NF-κB Akt MMP
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-126956

Porphyra 334	Structural Classification Classification of Application Fields Animals Sunscreen Ketones, Aldehydes, Acids Source classification Metabolic Disease Amino acids Cosmetic Research Disease Research Fields	Reactive Oxygen Species MMP
Porphyra 334 is an antioxidative and anti-photoaging agent. Porphyra 334 suppresses ROS production and the expression of MMPs following UVA irradiation .

HY-W745164

3,3′-Bisdemethylpinoresinol	Structural Classification Source classification Lignans Rubiaceae Morinda citrifolia Linn. Phenylpropanoids Plants	MMP
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L.	Keap1-Nrf2
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

Cat. No.	Product Name	Chemical Structure

HY-W749966

Octocrylene-d10

Octocrylene-d10 is the deuterium labeled Octocrylene. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths .

Octocrylene-d10
Octocrylene-d10 is the deuterium labeled Octocrylene. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths .

HY-B0316S

Avobenzone-13C,d3
Avobenzone- ¹³C,d₃ is the ¹³C- and deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2].

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Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

UVA

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products