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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

Ubiquitin activating enzyme

" in MCE Product Catalog:

By Targets:	E1/E2/E3 Enzyme (5) Apoptosis (3) NF-κB (1)
By Research Areas:	Cancer (5)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Targets Recommended: E1/E2/E3 Enzyme NEDD8-activating Enzyme Angiotensin-converting Enzyme (ACE) FLAP Platelet-activating Factor Receptor (PAFR) ATF6 IRE1 TET Protein

Cat. No.	Product Name	Target	Research Areas

HY-114304

COH000	E1/E2/E3 Enzyme	Cancer
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC₅₀ of 0.2 μM for SUMOylation in vitro.

HY-13296

PYR-41 5+ Cited Publications	E1/E2/E3 Enzyme Apoptosis	Cancer
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

HY-100487

TAK-243 Maximum Cited Publications 23 Publications Verification MLN7243	E1/E2/E3 Enzyme NF-κB Apoptosis	Cancer
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC₅₀=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.

HY-13297

PYZD-4409 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC₅₀ of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.

HY-13811

NSC697923 1 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library	240 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 240 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Ubiquitination Compound Library

240 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 240 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Product Name	Species	Source

HY-P71395

UBA5 Protein, Human (His)

Ubiquitin-like modifier-activating enzyme 5; ThiFP1; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1; UBE1DC1; UBA5
Human E. coli
HY-P74485

UBA1 Protein, Human (sf9, His-GST)

Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1
Human Sf9 insect cells

Cat. No.	Product Name	Application	Reactivity

HY-P80559

ATG7 Antibody hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L	WB	Human, Mouse, Rat
ATG7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to ATG7. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80365

Ubiquitin-like modifier-activating enzyme 1 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse
Ubiquitin-like modifier-activating enzyme 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 118 kDa, targeting to Ubiquitin-like modifier-activating enzyme 1. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

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