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Pathways Recommended:	Metabolic Enzyme/Protease Antibody-drug Conjugate/ADC Related

Results for "

Ubiquitin conjugating enzyme

" in MCE Product Catalog:

By Targets:	E1/E2/E3 Enzyme (3) Apoptosis (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Targets Recommended: E1/E2/E3 Enzyme Angiotensin-converting Enzyme (ACE) NEDD8-activating Enzyme IRE1 TET Protein

Cat. No.	Product Name	Target	Research Areas

HY-15301

CC0651	E1/E2/E3 Enzyme	Cancer
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC₅₀=1.72 μM) inhibits the ubiquitination of p27^Kip1, as confirmed by dose-response analysis.

HY-103046

UbcH5c-IN-1	E1/E2/E3 Enzyme	Inflammation/Immunology
UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a K_d of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent.

HY-13811

NSC697923	E1/E2/E3 Enzyme Apoptosis	Cancer
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library	220 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 220 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Ubiquitination Compound Library

220 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 220 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Species:	Human (22)
Tag:	His (9) T7 (1) Tag Free (2) GST (9)
Source:	HEK293 (1) E. coli (21)

Cat. No.	Product Name	Species	Source

HY-P71405

UBE2K Protein, Human (GST) Ubiquitin-conjugating enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG	Human	E. coli

HY-P71408

UBE2S Protein, Human (GST) Ubiquitin-conjugating enzyme E2 S; E2-EPF; Ubiquitin Carrier Protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-Protein Ligase S; UBE2S; E2EPF	Human	E. coli

HY-P71402

UBE2H Protein, Human (GST)
Ubiquitin-conjugating enzyme E2 H; UbcH2; Ubiquitin Carrier Protein H; Ubiquitin-conjugating enzyme E2-20K; Ubiquitin-Protein Ligase H; UBE2H
Human E. coli
HY-P71404

UBE2J2 Protein, Human (GST)
Ubiquitin-conjugating enzyme E2 J2; Non-Canonical Ubiquitin-conjugating enzyme 2; NCUBE-2; UBE2J2; NCUBE2
Human E. coli
HY-P71412

UBE2Z Protein, Human (His)
Ubiquitin-conjugating enzyme E2 Z; Uba6-Specific E2 conjugating enzyme 1; Use1; Ubiquitin Carrier Protein Z; Ubiquitin-Protein Ligase Z; UBE2Z; HOYS7
Human E. coli

HY-P70998

UBE2D3 Protein, Human Ubiquitin-conjugating enzyme E2 D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.	Human	E. coli

HY-P71403

UBE2I Protein, Human (GST) SUMO-conjugating enzyme UBC9; SUMO-Protein Ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9	Human	E. coli

HY-P71407

UBE2R2 Protein, Human (His) Ubiquitin-conjugating enzyme E2 R2; Ubiquitin Carrier Protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-Protein Ligase R2; UBE2R2; CDC34B; UBC3B	Human	E. coli

HY-P71398

UBE2B Protein, Human (HEK293, His) Ubiquitin-conjugating enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B	Human	HEK293

HY-P77272

UBE2W Protein, Human (His)
Ubiquitin-conjugating enzyme E2 W; UBC-16; Ubiquitin-protein ligase W; UBC16
Human E. coli

HY-P71399

UBE2D1 Protein, Human (GST) Ubiquitin-conjugating enzyme E2 D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1; SFT; UBC5A; UBCH5; UBCH5A	Human	E. coli

HY-P71406

UBE2M Protein, Human
NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;
Human E. coli
HY-P71401

UBE2G2 Protein, Human (GST)
Ubiquitin-conjugating enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2
Human E. coli
HY-P71409

UBE2T Protein, Human (His)
Ubiquitin-conjugating enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; UBE2T
Human E. coli
HY-P71400

UBE2D4 Protein, Human (GST)
Ubiquitin-conjugating enzyme E2 D4; HBUCE1; Ubiquitin Carrier Protein D4; Ubiquitin-Protein Ligase D4; UBE2D4; UBCH5D
Human E. coli
HY-P71397

UBE2A Protein, Human (GST-His)
Ubiquitin-conjugating enzyme E2 A; RAD6 Homolog A; HR6A; hHR6A; Ubiquitin Carrier Protein A; Ubiquitin-Protein Ligase A; UBE2A; RAD6A
Human E. coli
HY-P77271

UBE2G1 Protein, Human
Ubiquitin-conjugating enzyme E2 G1; E217K; UBC7; UBE2G1; UBE2G
Human E. coli
HY-P71410

UBE2V1 Protein, Human (His)
Ubiquitin-conjugating enzyme E2 Variant 1; UEV-1; CROC-1; TRAF6-Regulated IKK Activator 1 Beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19
Human E. coli

HY-P71411

UBE2V2 Protein, Human (His) Ubiquitin-conjugating enzyme E2 Variant 2; DDVit 1; Enterocyte Differentiation-Associated Factor 1; EDAF-1; Enterocyte Differentiation-Promoting Factor 1; EDPF-1; MMS2 Homolog; Vitamin D3-Inducible Protein; UBE2V2; MMS2; UEV2	Human	E. coli

HY-P71020

UBE2L6 Protein, Human (His) Ubiquitin/ISG15-conjugating enzyme E2 L6; Retinoic Acid-Induced Gene B Protein; RIG-B; UbcH8; Ubiquitin Carrier Protein L6; Ubiquitin-Protein Ligase L6; UBE2L6; UBCH8	Human	E. coli

HY-P7617

ATG3 Protein, Human rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L	Human	E. coli
ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.

HY-P7616

ATG10 Protein, Human (His-T7) rHuATG10, His, N-T7; Ubiquitin-Like-conjugating enzyme ATG10; Autophagy-Related Protein 10; APG10-Like; ATG10	Human	E. coli
ATG10 Protein, Human (His-T7) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a His tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation.

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