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Results for "

Ubiquitin ligase

" in MCE Product Catalog:

By Targets:	E1/E2/E3 Enzyme (19) E3 Ligase Ligand-Linker Conjugates (32) Ligands for E3 Ligase (22) ADC Linker (12) Apoptosis (10) Aryl Hydrocarbon Receptor (1) Autophagy (2) Bacterial (1) Bcl-2 Family (2) Bcr-Abl (1) Btk (1) c-Myc (1) CDK (2) Endogenous Metabolite (1) Epigenetic Reader Domain (3) Estrogen Receptor/ERR (3) FKBP (3) Histone Methyltransferase (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Ligands for Target Protein for PROTAC (6) MDM-2/p53 (7) Molecular Glues (8) NF-κB (2) Parasite (2) PROTAC Linkers (69) PROTACs (16) Sirtuin (1) SNIPERs (3) STAT (1) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (163) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (8) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (6) TCO (18) DBCO (2) PROTAC Synthesis (7) Azide (1) Alkynes (29)

173

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjugates E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas

HY-143346

CCW16

Others Cancer

CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders.

CCW16	Others	Cancer
CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders.

HY-44432

Navitoclax-piperazine ABT-263-piperazine	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604).

HY-10949

SMER3	E1/E2/E3 Enzyme	Cancer
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)^Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF^Met30.

HY-W595340

*E3 ubiquitin* ligase binder-1**	Ligands for E3 Ligase	Cancer
E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder. E3 ubiquitin ligase binder-1 is a ligand for E3 Ligase.

HY-143715

Cereblon inhibitor 1	Ligands for E3 Ligase	Cancer
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

HY-130683

Lenalidomide-propargyl-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312).

HY-49444

EN450	E1/E2/E3 Enzyme NF-κB	Cancer
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the *E2 ubiquitin* ligase UBE2D*. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase* and proteasome-dependent mechanism.

HY-130682

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312).

HY-W062696

BC-1382	E1/E2/E3 Enzyme	Inflammation/Immunology
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC₅₀≈ 5 nM).Anti-inflammatory activity.

HY-43722

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602).

HY-134417

NSC2805	Others	Cancer
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC₅₀ of 0.38 μM. NSC2805 can be used for the research of cancer.

HY-130815A

MAK683-CH2CH2COOH hydrochloride	Ligands for Target Protein for PROTAC Histone Methyltransferase	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).

HY-130815

MAK683-CH2CH2COOH	Histone Methyltransferase Ligands for Target Protein for PROTAC	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615).

HY-108640

HLI373	MDM-2/p53 Parasite Apoptosis	Cancer Infection
HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents. Antimalarial activity.

HY-108640A

HLI373 dihydrochloride	MDM-2/p53 Parasite Apoptosis	Cancer Infection
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents. Antimalarial activity.

HY-123967

RNF5 inhibitor inh-02	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 inhibitor inh-02 is a potent inhibitor of *E3 ubiquitin* ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC₅₀**=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research.

HY-128756

SIAIS178	PROTACs Bcr-Abl	Cancer
SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC₅₀ of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity.

HY-133046

VHL Ligand-Linker Conjugates 17	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader.

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate.

HY-153357

NRX-0492	Btk	Cancer
NRX-0492 is an orally active and potent degrader of BTK. NRX-0492 catalyzes ubiquitylation and proteasomal degradation of BTK with DC₅₀≤0.2 nM and DC₉₀≤0.5 nM, respectively. NRX-0492 inhibits B-cell receptor (BCR)-mediated signaling, transcriptional programs, and chemokine secretion. Moreover, NRX-0492 also links a noncovalent BTK-binding domain to Cereblon. Cereblon is an adaptor protein of the E3 ubiquitin ligase complex.

HY-120929

BI8622

3 Publications Verification

E1/E2/E3 Enzyme Cancer

BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC₅₀ of 3.1 μM.
HY-120204

BI8626

E1/E2/E3 Enzyme Cancer

BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC₅₀ of 0.9 μM.

BI8622 3 Publications Verification	E1/E2/E3 Enzyme	Cancer
BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC₅₀ of 3.1 μM.

BI8626	E1/E2/E3 Enzyme	Cancer
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC₅₀ of 0.9 μM.

HY-128807

E3 ligase Ligand 10	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-129653

E3 ligase Ligand 18	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-128811

E3 ligase Ligand 14	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-43961

E3 ligase Ligand 8 3 Publications Verification	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-128810

E3 ligase Ligand 13	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-128806

E3 ligase Ligand 9	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-111879

Biotin-BS	SNIPERs	Cancer
Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.

HY-144983

E3 ligase Ligand 22

Ligands for E3 Ligase Cancer

E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.
HY-144980

E3 ligase Ligand 21

Ligands for E3 Ligase Cancer

E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.

E3 ligase Ligand 22	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.

E3 ligase Ligand 21	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.

HY-111878

BzNH-BS	SNIPERs	Cancer
BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.

HY-144985

E3 ligase Ligand 23	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.

HY-152859

Brigimadlin

BI 907828
E1/E2/E3 Enzyme Cancer

Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent.

Brigimadlin BI 907828	E1/E2/E3 Enzyme	Cancer
Brigimadlin (BI 907828) is an *E3 ubiquitin-protein ligase* MDM-2** inhibitor. Brigimadlin serves as an antineoplastic agent.

HY-110204

Heclin	E1/E2/E3 Enzyme	Others
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits several HECT ligases in tissue culture cells (IC₅₀s=6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively).

HY-130270

AhR Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 57	E3 Ligase Ligand-Linker Conjugates	Cancer
AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) incorporates an IAP ligand for the E3 ubiquitin ligase, and a SNIPER linker. AhR Ligand-Linker Conjugates 1 can be used to design SNIPER.

HY-128842

PROTAC MDM2 Degrader-3	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

HY-128843

PROTAC MDM2 Degrader-4	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

HY-130988A

Ipatasertib-NH2 dihydrochloride GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride	Ligands for Target Protein for PROTAC	Cancer
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase.

HY-69220

7-Octynoic acid	PROTAC Linkers	Cancer
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-132288

Pom-8PEG	E3 Ligase Ligand-Linker Conjugates	Cancer
Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader.

HY-A0003B

Lenalidomide hemihydrate Maximum Cited Publications 29 Publications Verification CC-5013 hemihydrate	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer
Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a *ligand of ubiquitin* E3 ligase cereblon (CRBN)*, and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin* ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

HY-A0003

Lenalidomide Maximum Cited Publications 29 Publications Verification CC-5013	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer Inflammation/Immunology
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a *ligand of ubiquitin* E3 ligase cereblon (CRBN)*, and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin* ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

HY-A0003A

Lenalidomide hydrochloride CC-5013 hydrochloride	Ligands for E3 Ligase Molecular Glues	Cancer Inflammation/Immunology
Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a *ligand of ubiquitin* E3 ligase cereblon (CRBN)*, and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin* ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

HY-125906

VHL Ligand-Linker Conjugates 15 E3 ligase Ligand-Linker Conjugates 56	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs.

HY-131189

N-Boc-SBP-0636457-OH	Ligands for E3 Ligase	Cancer
N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1 (HY-131188).

HY-129395

Mezigdomide CC-92480	E1/E2/E3 Enzyme Molecular Glues Apoptosis	Cancer
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity.

HY-148130

Rugonersen RG6091; RO7248824	E1/E2/E3 Enzyme	Others
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch.

HY-128840

PROTAC MDM2 Degrader-1	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 is 15a of patent CN108610333A. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

HY-128822

cIAP1 Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 43	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 13 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 13 can be used to design SNIPERs.

HY-128813A

cIAP1 Ligand-Linker Conjugates 15 hydrochloride E3 ligase Ligand-Linker Conjugates 34 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs.

HY-128815

cIAP1 Ligand-Linker Conjugates 14 E3 ligase Ligand-Linker Conjugates 36	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs.

HY-128816A

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride E3 ligase Ligand-Linker Conjugates 37 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 Hydrochloride can be used to design SNIPERs.

HY-128820

cIAP1 Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 41	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs.

HY-128819

cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 40	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs.

HY-128826

cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 47	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 10 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs.

HY-128812A

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs.

HY-128813

cIAP1 Ligand-Linker Conjugates 15 E3 ligase Ligand-Linker Conjugates 34	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs.

HY-128824

cIAP1 Ligand-Linker Conjugates 9 E3 ligase Ligand-Linker Conjugates 45	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 9 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 9 can be used to design SNIPERs.

HY-128812

cIAP1 Ligand-Linker Conjugates 11 E3 ligase Ligand-Linker Conjugates 33	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs.

HY-128817

cIAP1 Ligand-Linker Conjugates 12 E3 ligase Ligand-Linker Conjugates 38	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs.

HY-128825

cIAP1 Ligand-Linker Conjugates 8 E3 ligase Ligand-Linker Conjugates 46	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 8 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 8 can be used to design SNIPERs.

HY-128823

cIAP1 Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 44	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 7 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 7 can be used to design SNIPERs.

HY-128818

cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs.

HY-128821

cIAP1 Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 42	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 4 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 4 can be used to design SNIPERs.

HY-128816

cIAP1 Ligand-Linker Conjugates 2 E3 ligase Ligand-Linker Conjugates 37	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 2 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 can be used to design SNIPERs.

HY-128814

cIAP1 Ligand-Linker Conjugates 6 hydrochloride E3 ligase Ligand-Linker Conjugates 35 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 6 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 6 hydrochloride can be used to design SNIPERs.

HY-108374

4-Azidobutylamine	PROTAC Linkers	Cancer
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-123937

THAL-SNS-032 1 Publications Verification	PROTACs CDK	Cancer
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

HY-128841

PROTAC MDM2 Degrader-2	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 is 15b of patent CN108610333A. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

HY-A0003S

Lenalidomide-d5 CC-5013-d₅	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer Inflammation/Immunology
Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

HY-N0170

Indole-3-carbinol 5+ Cited Publications I3C; 3-Indolemethanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-12025

Serdemetan 1 Publications Verification JNJ-26854165	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

HY-130988

Ipatasertib-NH2 GDC-0068-NH2; RG7440-NH2	Ligands for Target Protein for PROTAC	Cancer
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase.

HY-141432

Cbl-b-IN-3	E1/E2/E3 Enzyme	Cancer
Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC₅₀ of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.

HY-131232

Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557).

HY-129774

Phthalimide-PEG4-MPDM-OH	PROTAC Linkers	Cancer
Phthalimide-PEG4-MPDM-OH is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-MPDM-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-130715

tert-Butyl 11-aminoundecanoate	PROTAC Linkers	Cancer
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-129773

Phthalimide-PEG4-PDM-OTBS	PROTAC Linkers	Cancer
Phthalimide-PEG4-PDM-OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-PDM-OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-136163

(S,R,S)-AHPC-C2-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.

HY-135844

LS-102 2 Publications Verification	E1/E2/E3 Enzyme	Inflammation/Immunology
LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC₅₀ of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.

HY-133144

Lenalidomide-OH	Ligands for E3 Ligase	Cancer
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137).

HY-148671

(S,R,S)-AHPC-amido-C7-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.

HY-149316

Smurf1-IN-1	E1/E2/E3 Enzyme	Cardiovascular Disease
Smurf1-IN-1 is an orally active and selective inhibitor of *specific E3 ubiquitin* protein ligase 1 (SMURF1) with an IC₅₀** of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension.

HY-148173

NUCC-0223619

Indoleamine 2,3-Dioxygenase (IDO) Others

NUCC-0223619 is an IDO1 inhibitor, induce degradation of IDO protein. NUCC-0223619 can be used to synthesis PROTAC.

HY-136160

Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs.

HY-131318

Lenalidomide-I	Ligands for E3 Ligase	Cancer
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609).

HY-130835

FKBP12 PROTAC RC32 RC32	PROTACs FKBP	Cancer
FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984).

HY-129772

Phthalimide-PEG3-C2-OTs	PROTAC Linkers	Cancer
Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-40178

NH2-C4-NH-Boc	PROTAC Linkers	Cancer
NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-122702

PEG6-(CH2CO2H)2	PROTAC Linkers	Others
PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

HY-132992

EN219-O-C4-NH2 TFA	E3 Ligase Ligand-Linker Conjugates	Cancer
EN219-O-C4-NH2 TFA incorporates an E3 ubiquitin ligase ligand, and a PROTAC linker. EN219-O-C4-NH2 TFA can be used to design PROTACs.

HY-130798

(S,R,S)-AHPC-amido-C5-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).

HY-129610

KB02-SLF	PROTACs FKBP	Cancer
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF.

HY-14658

Thalidomide 10+ Cited Publications	Ligands for E3 Ligase Molecular Glues Autophagy Apoptosis Bacterial	Cancer Inflammation/Immunology
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-110195

Smurf1-IN-A01 1 Publications Verification A01	Others	Others
Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a k_d of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.

HY-123844

dBET57 2 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
dBET57 is a potent and selective degrader of BRD4_BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4^Cereblon E3 ubiquitin ligase, with a DC_50/5h of 500 nM for BRD4_BD1, and is inactive on BRD4_BD2.

HY-112811

PROTAC CDK9 degrader-2	PROTACs CDK	Cancer
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC₅₀ of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC.

HY-14658S

Thalidomide D4	Ligands for E3 Ligase Molecular Glues Autophagy Apoptosis	Cancer Inflammation/Immunology
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

HY-145898

WBC100 14-D-Valine-TPL	c-Myc Molecular Glues	Cancer
WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c‐Myc molecule glue degrader. WBC100 is a c‐Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c‐Myc overexpressing tumors research.

HY-130618

Boc-C1-PEG3-C4-OH	PROTAC Linkers	Cancer
Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-130713

Thalidomide-C2-amido-C2-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709).

HY-112098

PROTAC ERα Degrader-1	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.

HY-131385

KB02-COOH	Ligands for E3 Ligase	Cancer
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610).

HY-130619

Boc-C1-PEG3-C4-OBn	PROTAC Linkers	Cancer
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-141178

TCO-PEG3-amine

PROTAC Linkers Cancer

TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141181

TCO-PEG8-amine

PROTAC Linkers Cancer

TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133049

Propargyl-PEG3-phosphonic acid

PROTAC Linkers Cancer

Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130146

Propargyl-PEG3-phosphonic acid diethyl ester

PROTAC Linkers Cancer

Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130382

Propargyl-PEG6-alcohol

PROTAC Linkers Cancer

Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-121507

Hydroxy-PEG2-C2-sulfonic acid

PROTAC Linkers Cancer

Hydroxy-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130554

m-PEG9-phosphonic acid

PROTAC Linkers Cancer

m-PEG9-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141187

TCO-PEG3-TCO

PROTAC Linkers Cancer

TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-41921

Propargyl-PEG3-alcohol

PROTAC Linkers Cancer

Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130390

Propargyl-PEG4-O-C1-NHS ester

PROTAC Linkers Cancer

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141159

TCO-PEG4-acid

PROTAC Linkers Cancer

TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141166

TCO-PEG3-NHS ester

PROTAC Linkers Cancer

TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133230

Propargyl-PEG10-amine

PROTAC Linkers Cancer

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130563

Propargyl-PEG3-CH2COOH

PROTAC Linkers Cancer

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-112559

Bis-PEG2-acid

PROTAC Linkers Cancer

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141160

TCO-PEG6-acid

PROTAC Linkers Cancer

TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-115414

Bis-propargyl-PEG8

PROTAC Linkers Cancer

Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130147

Propargyl-PEG5-OH

PROTAC Linkers Cancer

Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141161

TCO-PEG8-acid

PROTAC Linkers Cancer

TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141183

TCO-PEG4-biotin

PROTAC Linkers Cancer

TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130374

Propargyl-PEG8-OH

PROTAC Linkers Cancer

Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133229

Propargyl-PEG4-alcohol

PROTAC Linkers Cancer

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130137

m-PEG8-C10-phosphonic acid

PROTAC Linkers Cancer

m-PEG8-C10-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141180

TCO-PEG6-amine

PROTAC Linkers Cancer

TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130389

Propargyl-PEG4-O-C1-Boc

PROTAC Linkers Cancer

Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130375

Propargyl-PEG8-Boc

PROTAC Linkers Cancer

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-117045

Propargyl-PEG12-OH

PROTAC Linkers Cancer

Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-126977

Propargyl-PEG9-OH

PROTAC Linkers Cancer

Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141189

TCO-PEG8-TCO

PROTAC Linkers Cancer

TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141179

TCO-PEG4-amine

PROTAC Linkers Cancer

TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-120587

Bis-PEG6-acid

PROTAC Linkers Cancer

Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141177

TCO-PEG2-amine

PROTAC Linkers Cancer

TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-126891

Bis-PEG3-acid

PROTAC Linkers Cancer

Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141169

TCO-PEG8-NHS ester

PROTAC Linkers Cancer

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130378

Propargyl-PEG7-alcohol

PROTAC Linkers Cancer

Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130584

Propargyl-PEG2-Ms

PROTAC Linkers Cancer

Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-114670

Propargyl-PEG4-amine

PROTAC Linkers Cancer

Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141162

TCO-PEG12-acid

PROTAC Linkers Cancer

TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130373

Propargyl-PEG9-amine

PROTAC Linkers Cancer

Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130819

Tos-PEG4-THP

PROTAC Linkers Cancer

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).
HY-130380

Propargyl-PEG7-Boc

PROTAC Linkers Cancer

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130384

Propargyl-PEG6-Boc

PROTAC Linkers Cancer

Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141188

TCO-PEG4-TCO

PROTAC Linkers Cancer

TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-113921

m-PEG4-propargyl

PROTAC Linkers Cancer

m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141168

TCO-PEG6-NHS ester

PROTAC Linkers Cancer

TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-140015

TCO-PEG3-acid

PROTAC Linkers Cancer

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-130816

(S,R,S)-AHPC-O-Ph-PEG1-NH2 VH032-O-Ph-PEG1-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pK_D of 9.02.

HY-129917

KB02-JQ1	PROTACs Epigenetic Reader Domain	Cancer
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1.

HY-136008A

(S,R,S)-AHPC-PEG1-NH2 dihydrochloride VH032-PEG1-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-PEG1-NH2 dihydrochloride can be used to design PROTACs.

HY-129602

SD-36 2 Publications Verification	PROTACs STAT Apoptosis	Cancer
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase.

HY-145071

PROTAC ERα Y537S degrader-1	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader.

HY-110174

NAB2	Others	Neurological Disease
NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a agentgable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking.

HY-103636

PROTAC Sirt2 Degrader-1	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM).

HY-140902A

Biotin-PEG3-C3-NH2

PROTAC Linkers Cancer

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH₂ functional group, that can be used in the synthesis of PROTACs.

HY-129619

SNIPER(ER)-87	SNIPERs Estrogen Receptor/ERR	Cancer
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC₅₀=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation.

HY-123941

FKBP12 PROTAC dTAG-7 dTAG-7	PROTACs FKBP Epigenetic Reader Domain	Cancer
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12^F36V with expression of FKBP12^F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN.

HY-126885

DBCO-PEG5-NHS ester	ADC Linker PROTAC Linkers	Cancer
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126892

Bis-PEG7-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130408

m-PEG6-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W018174

m-PEG3-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG3-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130387

Propargyl-PEG4-Tos	PROTAC Linkers ADC Linker	Cancer
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126894

Bis-PEG9-acid	PROTAC Linkers ADC Linker	Cancer
Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-118808

Propargyl-PEG2-NHBoc	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126976

Propargyl-PEG5-amine	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126893

Bis-PEG8-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140310

TCO-PEG4-DBCO	ADC Linker PROTAC Linkers	Cancer
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W051634

Propargyl-PEG2-amine	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-130410

Bis-PEG6-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library

240 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 240 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

HY-L128

E3 Ligase Ligand Library

55 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 55 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Cat. No.	Product Name	Target	Category

HY-N0170

Indole-3-carbinol 5+ Cited Publications I3C; 3-Indolemethanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Indole Alkaloids Alkaloids Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families Endogenous metabolite
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

Species:	Human (28) Mouse (3)
Tag:	His (16) SUMO (1) Tag Free (4) Avi (1) GST (12) Fc (2)
Source:	HEK293 (4) Sf9 insect cells (3) P. pastoris (1) E. coli (23)

Cat. No.	Product Name	Species	Source

HY-P71403

UBE2I Protein, Human (GST) SUMO-Conjugating Enzyme UBC9; SUMO-Protein ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Conjugating Enzyme E2 I; Ubiquitin-Protein ligase I; p18; UBE2I; UBC9; UBCE9	Human	E. coli

HY-P71401

UBE2G2 Protein, Human (GST)

Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein ligase G2; UBE2G2
Human E. coli
HY-P77272

UBE2W Protein, Human (His)

Ubiquitin-conjugating enzyme E2 W; UBC-16; Ubiquitin-protein ligase W; UBC16
Human E. coli
HY-P71402

UBE2H Protein, Human (GST)

Ubiquitin-Conjugating Enzyme E2 H; UbcH2; Ubiquitin Carrier Protein H; Ubiquitin-Conjugating Enzyme E2-20K; Ubiquitin-Protein ligase H; UBE2H
Human E. coli

HY-P71408

UBE2S Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 S; E2-EPF; Ubiquitin Carrier Protein S; Ubiquitin-Conjugating Enzyme E2-24 kDa; Ubiquitin-Conjugating Enzyme E2-EPF5; Ubiquitin-Protein ligase S; UBE2S; E2EPF	Human	E. coli

HY-P71409

UBE2T Protein, Human (His)

Ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein ligase T; UBE2T
Human E. coli

HY-P71405

UBE2K Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein ligase; UBE2K; HIP2; LIG	Human	E. coli

HY-P71400

UBE2D4 Protein, Human (GST)

Ubiquitin-Conjugating Enzyme E2 D4; HBUCE1; Ubiquitin Carrier Protein D4; Ubiquitin-Protein ligase D4; UBE2D4; UBCH5D
Human E. coli

HY-P71407

UBE2R2 Protein, Human (His) Ubiquitin-Conjugating Enzyme E2 R2; Ubiquitin Carrier Protein R2; Ubiquitin-Conjugating Enzyme E2-CDC34B; Ubiquitin-Protein ligase R2; UBE2R2; CDC34B; UBC3B	Human	E. coli

HY-P71398

UBE2B Protein, Human (HEK293, His) Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein ligase B; UBE2B; RAD6B	Human	HEK293

HY-P73485

XIAP Protein, Human (Avi)

E3 Ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4
Human E. coli
HY-P73537

XIAP Protein, Human (His)

E3 Ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4
Human E. coli
HY-P71397

UBE2A Protein, Human (GST-His)

Ubiquitin-Conjugating Enzyme E2 A; RAD6 Homolog A; HR6A; hHR6A; Ubiquitin Carrier Protein A; Ubiquitin-Protein ligase A; UBE2A; RAD6A
Human E. coli
HY-P71412

UBE2Z Protein, Human (His)

Ubiquitin-Conjugating Enzyme E2 Z; Uba6-Specific E2 Conjugating Enzyme 1; Use1; Ubiquitin Carrier Protein Z; Ubiquitin-Protein ligase Z; UBE2Z; HOYS7
Human E. coli

HY-P70998

UBE2D3 Protein, Human Ubiquitin-conjugating enzyme E2 D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.	Human	E. coli

HY-P74343

CBLC Protein, Human (sf9, His-GST)

E3 Ubiquitin-protein ligase CBL-C; CBLC; CBL3; RNF57
Human Sf9 insect cells
HY-P78030

RNF43 Protein, Mouse (HEK293, Fc)

E3 Ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 Ubiquitin transferase RNF43; Rnf43
Mouse HEK293
HY-P75894

ITCH/AIP4 Protein, Human (380a.a)

E3 Ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH
Human E. coli

HY-P71020

UBE2L6 Protein, Human (His) Ubiquitin/ISG15-Conjugating Enzyme E2 L6; Retinoic Acid-Induced Gene B Protein; RIG-B; UbcH8; Ubiquitin Carrier Protein L6; Ubiquitin-Protein ligase L6; UBE2L6; UBCH8	Human	E. coli

HY-P75970

Pellino-1 Protein, Human (sf9, His-GST)

E3 Ubiquitin-protein ligase pellino homolog 1; PELI1; PRISM
Human Sf9 insect cells
HY-P77151

PPIL2 Protein, Human (His)

RING-type E3 Ubiquitin-protein ligase PPIL2; CYC4; Cyp60; Rotamase PPIL2
Human E. coli
HY-P76007

RNF43 Protein, Human (HEK293, Fc)

E3 Ubiquitin-protein ligase RNF43; RING finger protein 43; RNF43
Human HEK293
HY-P76008

RNF43 Protein, Human (HEK293, His)

E3 Ubiquitin-protein ligase RNF43; RING finger protein 43; RNF43
Human HEK293

HY-P71399

UBE2D1 Protein, Human (GST) Ubiquitin-conjugating enzyme E2 D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1; SFT; UBC5A; UBCH5; UBCH5A	Human	E. coli

HY-P77507

WWP2 Protein, Human (sf9, His-GST)

NEDD4-like E3 Ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; AIP2; WWP2
Human Sf9 insect cells
HY-P71406

UBE2M Protein, Human

NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;
Human E. coli

HY-P700392

UBAC1 Protein, Human (GST) UBAC1; UBA domain containing 1; UBADC1, Ubiquitin associated domain containing 1; Ubiquitin-associated domain-containing protein 1; GBDR1; UBA domain-containing protein 1; E3 Ubiquitin-protein ligase subunit KPC2; Ubiquitin associated domain containing 1; kip1 Ubiquitination-promoting complex protein 2; glialblastoma cell differentiation-related protein 1; putative glialblastoma cell differentiation-related protein; UBADC1; RP11-432J22.3	Human	E. coli

HY-P71570

TRIM21 Protein, Mouse (His-SUMO) Trim21; Ro52; Ssa1; E3 Ubiquitin-protein ligase TRIM21; EC 2.3.2.27; 52kDa Ro protein; 52kDa ribonucleoprotein autoantigen Ro/SS-A; RING-type E3 Ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21	Mouse	E. coli

HY-P71340

STUB1 Protein, Human E3 Ubiquitin-Protein ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP	Human	E. coli

HY-P700593

MAP3K1 Protein, Mouse (His) MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 Ubiquitin protein ligase; mitogen-activated protein kinase kinase kinase 1	Mouse	E. coli

HY-P700503

TRIM24 Protein, Human (P. pastoris, His) TRIM24; tripartite motif containing 24; TIF1, transcriptional intermediary factor 1 , tripartite motif containing 24; transcription intermediary factor 1-alpha; hTIF1; RNF82; TIF1A; Tif1a; TIF1-alpha; RING finger protein 82; tripartite motif-containing 24; E3 Ubiquitin-protein ligase TRIM24; transcriptional intermediary factor 1; PTC6; TF1A; TIF1; TIF1ALPHA	Human	P. pastoris

Cat. No.	Product Name

HY-14658S

Thalidomide D4
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80919

TRAF6 Antibody TRAF6; RNF85; TNF receptor-associated factor 6; E3 Ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85	WB	Human, Rat
TRAF6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to TRAF6. It can be used for WB assays with tag free, in the background of Human, Rat.

Cat. No.	Product Name		Classification

HY-69220

7-Octynoic acid		Alkynes
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-108374

4-Azidobutylamine		PROTAC Synthesis Azide
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

HY-130682

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride		Alkynes
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312).

HY-141178

TCO-PEG3-amine

TCO

TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141181

TCO-PEG8-amine

TCO

TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133049

Propargyl-PEG3-phosphonic acid

Alkynes

Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130146

Propargyl-PEG3-phosphonic acid diethyl ester

Alkynes

Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130382

Propargyl-PEG6-alcohol

Alkynes

Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141187

TCO-PEG3-TCO

TCO

TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-41921

Propargyl-PEG3-alcohol

Alkynes

Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130390

Propargyl-PEG4-O-C1-NHS ester

Alkynes

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141159

TCO-PEG4-acid

TCO

TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141166

TCO-PEG3-NHS ester

TCO

TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133230

Propargyl-PEG10-amine

Alkynes

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130563

Propargyl-PEG3-CH2COOH

Alkynes

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141160

TCO-PEG6-acid

TCO

TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-115414

Bis-propargyl-PEG8

Alkynes

Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130147

Propargyl-PEG5-OH

Alkynes

Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141161

TCO-PEG8-acid

TCO

TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141183

TCO-PEG4-biotin

TCO

TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130374

Propargyl-PEG8-OH

Alkynes

Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-133229

Propargyl-PEG4-alcohol

Alkynes

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141180

TCO-PEG6-amine

TCO

TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130389

Propargyl-PEG4-O-C1-Boc

Alkynes

Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130375

Propargyl-PEG8-Boc

Alkynes

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-117045

Propargyl-PEG12-OH

Alkynes

Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-126977

Propargyl-PEG9-OH

Alkynes

Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141189

TCO-PEG8-TCO

TCO

TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141179

TCO-PEG4-amine

TCO

TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141177

TCO-PEG2-amine

TCO

TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141169

TCO-PEG8-NHS ester

TCO

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130378

Propargyl-PEG7-alcohol

Alkynes

Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130584

Propargyl-PEG2-Ms

Alkynes

Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-114670

Propargyl-PEG4-amine

Alkynes

Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141162

TCO-PEG12-acid

TCO

TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130373

Propargyl-PEG9-amine

Alkynes

Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130380

Propargyl-PEG7-Boc

Alkynes

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130384

Propargyl-PEG6-Boc

Alkynes

Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141188

TCO-PEG4-TCO

TCO

TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-113921

m-PEG4-propargyl

Alkynes

m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-141168

TCO-PEG6-NHS ester

TCO

TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-140015

TCO-PEG3-acid

TCO

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-129602

SD-36 2 Publications Verification		Alkynes
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase.

HY-126885

DBCO-PEG5-NHS ester		DBCO ADC Synthesis PROTAC Synthesis
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130387

Propargyl-PEG4-Tos		ADC Synthesis PROTAC Synthesis Alkynes
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-118808

Propargyl-PEG2-NHBoc		Alkynes ADC Synthesis PROTAC Synthesis
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126976

Propargyl-PEG5-amine		PROTAC Synthesis Alkynes ADC Synthesis
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-140310

TCO-PEG4-DBCO		TCO DBCO ADC Synthesis PROTAC Synthesis
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W051634

Propargyl-PEG2-amine		PROTAC Synthesis ADC Synthesis Alkynes
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Ubiquitin ligase

Inhibitors & Agonists

Screening Libraries

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
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