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Ubiquitin

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  • HY-P71402
    UBE2H Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 H; UbcH2; Ubiquitin Carrier Protein H; Ubiquitin-Conjugating Enzyme E2-20K; Ubiquitin-Protein Ligase H; UBE2H

    		 Human E. coli
    UBE2H Protein, a crucial participant in cellular ubiquitination, transfers ubiquitin from the E1 complex to various proteins, including MAEA of the CTLH E3 ubiquitin-protein ligase complex. Versatile in vitro, UBE2H catalyzes both 'Lys-11'- and 'Lys-48'-linked polyubiquitination, showcasing its involvement in diverse ubiquitin-related processes. Notably, it demonstrates the capability to ubiquitinate histone H2A in vitro. UBE2H Protein, Human (GST) is the recombinant human-derived UBE2H protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2H Protein, Human (GST) is 183 a.a., with molecular weight of ~50.0 kDa.
  • HY-P701493
    UBE2O Protein, Human (Sf9, His, Strep)

    UBE2O; (E3-independent) E2 Ubiquitin-conjugating enzyme; E2/E3 hybrid Ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O

    		 Human Sf9 insect cells
    UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2O protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE2O Protein, Human (Sf9, His, Strep) is 1291 a.a., .
  • HY-P701494
    UBE2O Protein, Human (Sf9)

    UBE2O; (E3-independent) E2 Ubiquitin-conjugating enzyme; E2/E3 hybrid Ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O

    		 Human Sf9 insect cells
    UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (Sf9) is the recombinant human-derived UBE2O protein, expressed by Sf9 insect cells , with tag free. The total length of UBE2O Protein, Human (Sf9) is 1291 a.a., .
  • HY-P71408
    UBE2S Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 S; E2-EPF; Ubiquitin Carrier Protein S; Ubiquitin-Conjugating Enzyme E2-24 kDa; Ubiquitin-Conjugating Enzyme E2-EPF5; Ubiquitin-Protein Ligase S; UBE2S; E2EPF

    		 Human E. coli
    UBE2S Protein, crucial in cellular ubiquitination, accepts ubiquitin from the E1 complex, catalyzing covalent attachment to various proteins. A key contributor to cell cycle regulation, UBE2S catalyzes 'Lys-11'-linked polyubiquitination, essential for anaphase promoting complex/cyclosome (APC/C) function. It plays a crucial role in mitotic progression by elongating 'Lys-11'-linked polyubiquitin chains initiated by UBE2C/UBCH10 on APC/C substrates, facilitating mitotic exit. Implicated in ubiquitination and degradation of VHL, UBE2S promotes polyubiquitination using all seven ubiquitin Lys residues in vitro, excluding 'Lys-48'-linked polyubiquitination, highlighting its versatility. UBE2S Protein, Human (GST) is the recombinant human-derived UBE2S protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2S Protein, Human (GST) is 222 a.a., with molecular weight of ~50.0 kDa.
  • HY-P701350
    UBE2C Protein, Human (Sf9, His, Strep)

    UBE2C; Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 Ubiquitin-conjugating enzyme C; E2 Ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

    		 Human Sf9 insect cells
    The UBE2C protein is a key ubiquitin-proteasome system component that acts as an E2 ubiquitin-conjugating enzyme and is the core of the covalent linkage of ubiquitin to target proteins. In vitro, UBE2C expertly promotes “Lys-11” and “Lys-48” linked polyubiquitination, demonstrating the versatility of ubiquitin chain formation. UBE2C Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2C protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE2C Protein, Human (Sf9, His, Strep) is 178 a.a., .
  • HY-P71405
    UBE2K Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG

    		 Human E. coli
    UBE2K Protein, a vital component of the ubiquitin-proteasome system, functions as an E2 ubiquitin-conjugating enzyme, crucial for attaching ubiquitin to diverse substrates. In vitro, UBE2K catalyzes 'Lys-48'-linked polyubiquitin chains, particularly with or without the BRCA1-BARD1 E3 ligase complex. It participates in the selective degradation of short-lived proteins, including endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. UBE2K exhibits ubiquitination activity towards targets like huntingtin and p53/TP53, and potentially NF-kappa-B. Its role in viral infections involves contributing to MHC class I heavy chain degradation and participating in HPV E7 protein-dependent degradation of RB1. UBE2K Protein, Human (GST) is the recombinant human-derived UBE2K protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2K Protein, Human (GST) is 200 a.a., with molecular weight of ~45.0 kDa.
  • HY-P79457
    USP2 Catalytic Domain Protein, Human (His)

    Ubiquitin Specific Peptidase 2; UBP41; Ubiquitin-Specific-Processing Protease 2; Ubiquitin Carboxyl-Terminal Hydrolase 2; 41 KDa Ubiquitin-Specific Protease; DeUbiquitinating Enzyme 2; Ubiquitin-specific Protease 2

    		Human E. coli
    USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Catalytic Domain Protein, Human (His) is the recombinant human-derived USP2 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag. The total length of USP2 Catalytic Domain Protein, Human (His) is 347 a.a., .
  • HY-P701422
    USP48 Protein, Human (Sf9, FLAG)

    USP48; Ubiquitin carboxyl-terminal hydrolase 48; DeUbiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific peptidase 48; Ubiquitin-specific protease 48; Ubiquitin-specific-processing protease 48

    		 Human Sf9 insect cells
    USP48 protein, a deubiquitinase, hydrolyzes ubiquitin bonds at the C-terminal Gly, processing poly-ubiquitin precursors and ubiquitinated proteins. It may regulate NF-kappa-B activation by the TNF receptor superfamily via RELA and TRAF2 interactions. With potential roles at postsynaptic sites, USP48 exhibits multifunctionality, influencing ubiquitin processing and signaling pathways involved in immune response and synaptic function. USP48 Protein, Human (Sf9, FLAG) is the recombinant human-derived USP48 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of USP48 Protein, Human (Sf9, FLAG) is 1034 a.a., .
  • HY-P701487
    UB2E3 Protein, Human (Sf9)

    UBE2E3; Ubiquitin-conjugating enzyme E2 E3; E2 Ubiquitin-conjugating enzyme E3; UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3

    		 Human Sf9 insect cells
    UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (Sf9) is the recombinant human-derived UB2E3 protein, expressed by Sf9 insect cells , with tag free. The total length of UB2E3 Protein, Human (Sf9) is 206 a.a., .
  • HY-P701349
    USP2 Protein, Human

    USP2; Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa Ubiquitin-specific protease; DeUbiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2

    		 Human E. coli
    USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free. The total length of USP2 Protein, Human is 347 a.a., .
  • HY-P701490
    UB2E3 Protein, Human (Sf9, His, Strep)

    UBE2E3; Ubiquitin-conjugating enzyme E2 E3; E2 Ubiquitin-conjugating enzyme E3; UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3

    		 Human Sf9 insect cells
    UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2E3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2E3 Protein, Human (Sf9, His, Strep) is 206 a.a., .
  • HY-P701495
    UB2Q2 Protein, Human (Sf9)

    UBE2Q2; Ubiquitin-conjugating enzyme E2 Q2; E2 Ubiquitin-conjugating enzyme Q2; Ubiquitin carrier protein Q2; Ubiquitin-protein ligase Q2

    		 Human Sf9 insect cells
    The UB2Q2 protein is a component of the ubiquitin-proteasome system and functions as an E2 ubiquitin-conjugating enzyme, adept at accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to a variety of protein substrates. In vitro, UB2Q2 efficiently mediates “Lys-48”-linked polyubiquitination. UB2Q2 Protein, Human (Sf9) is the recombinant human-derived UB2Q2 protein, expressed by Sf9 insect cells , with tag free. The total length of UB2Q2 Protein, Human (Sf9) is 374 a.a., .
  • HY-P701406
    UCHL5 Protein, Human

    UCHL5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH-L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5

    		 Human E. coli
    UCHL5 is a highly specific protease that acts as a deubiquitinating enzyme intricately linked to the 19S proteasome subunit, cleaving "Lys-48" linked polyubiquitin chains. Although the INO80 complex is inert, transient interactions between INO80 and the proteasome (facilitated by ADRM1) activate UCHL5. UCHL5 Protein, Human is the recombinant human-derived UCHL5 protein, expressed by E. coli , with tag free. The total length of UCHL5 Protein, Human is 328 a.a., .
  • HY-P701413
    USP16 Protein, Human (Sf9)

    USP16; Ubiquitin carboxyl-terminal hydrolase 16; DeUbiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16

    		 Human Sf9 insect cells
    The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (Sf9) is the recombinant human-derived USP16 protein, expressed by Sf9 insect cells , with tag free. The total length of USP16 Protein, Human (Sf9) is 822 a.a., .
  • HY-P702065
    UB2D3 Protein, Human (Sf9, His, Strep)

    UBE2D3; Ubiquitin-conjugating enzyme E2 D3; (E3-independent) E2 Ubiquitin-conjugating enzyme D3; E2 Ubiquitin-conjugating enzyme D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3

    		 Human Sf9 insect cells
    The UBE2D3 protein is a key player in ubiquitination. It accepts ubiquitin from the E1 complex and covalently attaches it to a variety of proteins, demonstrating multifunctionality. It catalyzes "Lys-11" and "Lys-48" linked polyubiquitination in vitro, regulating protein ubiquitination patterns. UB2D3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2D3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2D3 Protein, Human (Sf9, His, Strep) is 146 a.a., .
  • HY-P79451
    UbcH7/UBE2L3 Protein, Human

    Ubiquitin-conjugating enzyme E2 L3; UBE2L3; E2 Ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3; UBCE7

    		Human E. coli
    UbcH7/UBE2L3 is a unique ubiquitin-conjugating E2 enzyme that cooperates with HECT-type and RBR family E3 ligases and lacks intrinsic E3-independent reactivity with lysine. It uniquely works with RBR family E3 enzymes such as PRKN, RNF31 and ARIH1, acting like a RING-HECT hybrid. UbcH7/UBE2L3 Protein, Human is the recombinant human-derived UbcH7/UBE2L3 protein, expressed by E. coli , with tag free. The total length of UbcH7/UBE2L3 Protein, Human is 154 a.a., with molecular weight of ~18 kDa.
  • HY-P701412
    USP16 Protein, Human (Sf9, His)

    USP16; Ubiquitin carboxyl-terminal hydrolase 16; DeUbiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16

    		 Human Sf9 insect cells
    The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (Sf9, His) is the recombinant human-derived USP16 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of USP16 Protein, Human (Sf9, His) is 822 a.a., .
  • HY-P701488
    UB2E2 Protein, Human (Sf9)

    UBE2E2; Ubiquitin-conjugating enzyme E2 E2; E2 Ubiquitin-conjugating enzyme E2; UbcH8; Ubiquitin carrier protein E2; Ubiquitin-protein ligase E2

    		 Human Sf9 insect cells
    The UB2E2 protein is a key ubiquitin-proteasome system participant, acting as an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to proteins. In vitro, UB2E2 exhibits multifunctionality by catalyzing polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E2 Protein, Human (Sf9) is the recombinant human-derived UB2E2 protein, expressed by Sf9 insect cells , with tag free. The total length of UB2E2 Protein, Human (Sf9) is 200 a.a., .
  • HY-P79448
    UBE2R1/CDC34 Protein, Human (Sf9, His, Strep)

    Ubiquitin-conjugating enzyme E2 R1; CDC34; (E3-independent) E2 Ubiquitin-conjugating enzyme R1 (EC:2.3.2.24); E2 Ubiquitin-conjugating enzyme R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protei

    		 Human Sf9 insect cells
    The UBE2R1/CDC34 protein is an important ubiquitin-proteasome system component that functions as an E2 ubiquitin-conjugating enzyme, capable of proficiently accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to a variety of protein substrates. . In vitro, UBE2R1 efficiently mediates “Lys-48”-linked polyubiquitination. UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE2R1/CDC34 protein, expressed by Sf9 insect cells , with N-Strep, N-His labeled tag. The total length of UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) is 235 a.a., .
  • HY-P71401
    UBE2G2 Protein, Human (GST)

    Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2

    		 Human E. coli
    UBE2G2 Protein, a vital ubiquitination component, accepts ubiquitin from the E1 complex, catalyzing its covalent attachment to various proteins, with a preference for 'Lys-48'-linked polyubiquitination. Its specificity in shaping ubiquitin chains underscores its role in cellular processes. Intricately associated with endoplasmic reticulum-associated degradation (ERAD), UBE2G2 maintains cellular homeostasis by regulating protein turnover. Indispensable for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, it facilitates subsequent proteasomal degradation. UBE2G2 Protein, Human (GST) is the recombinant human-derived UBE2G2 protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2G2 Protein, Human (GST) is 165 a.a., with molecular weight of ~43.0 kDa.
  • HY-P701491
    UB2Q1 Protein, Human (His, Strep)

    UBE2Q1; Ubiquitin-conjugating enzyme E2 Q1; E2 Ubiquitin-conjugating enzyme Q1; Protein NICE-5; Ubiquitin carrier protein Q1; Ubiquitin-protein ligase Q1

    		 Human E. coli
    Studies have shown that the UB2Q1 protein plays a key role in cellular processes by catalyzing the covalent attachment of ubiquitin to other proteins. In addition to its ubiquitination function, UB2Q1 may also be involved in female hormonal homeostasis. UB2Q1 Protein, Human (His, Strep) is the recombinant human-derived UB2Q1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of UB2Q1 Protein, Human (His, Strep) is 421 a.a., .
  • HY-P701346
    UbcH6/UBE2E1 Protein, Human (Sf9)

    UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 Ubiquitin-conjugating enzyme E1; E2 Ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1

    		 Human Sf9 insect cells
    The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (Sf9) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by Sf9 insect cells , with tag free. The total length of UbcH6/UBE2E1 Protein, Human (Sf9) is 192 a.a., .
  • HY-P701348
    UbcH7/UBE2L3 Protein, Human (Sf9, His, Strep)

    UBE2L3; Ubiquitin-conjugating enzyme E2 L3; E2 Ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3

    		 Human Sf9 insect cells
    UbcH7/UBE2L3 is a unique ubiquitin-conjugating E2 enzyme that cooperates with HECT-type and RBR family E3 ligases and lacks intrinsic E3-independent reactivity with lysine. It uniquely works with RBR family E3 enzymes such as PRKN, RNF31 and ARIH1, acting like a RING-HECT hybrid. UbcH7/UBE2L3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UbcH7/UBE2L3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UbcH7/UBE2L3 Protein, Human (Sf9, His, Strep) is 153 a.a., .
  • HY-P701496
    UB2E2 Protein, Human (Sf9, His, Strep)

    UBE2E2; Ubiquitin-conjugating enzyme E2 E2; E2 Ubiquitin-conjugating enzyme E2; UbcH8; Ubiquitin carrier protein E2; Ubiquitin-protein ligase E2

    		 Human Sf9 insect cells
    The UB2E2 protein is a key ubiquitin-proteasome system participant, acting as an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to proteins. In vitro, UB2E2 exhibits multifunctionality by catalyzing polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E2 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2E2 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2E2 Protein, Human (Sf9, His, Strep) is 200 a.a., .
  • HY-P701839
    ubiquitin Protein, Human (His)

    UBC; PolyUbiquitin-C

    		 Human E. coli
    Ubiquitin is a multifunctional protein that can form covalently linked isopeptide bonds in various states, including mono- and polyubiquitin chains. ubiquitin Protein, Human (His) is the recombinant human-derived ubiquitin protein, expressed by E. coli , with N-His labeled tag. The total length of ubiquitin Protein, Human (His) is 75 a.a., .
  • HY-P701347
    UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep)

    UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 Ubiquitin-conjugating enzyme E1; E2 Ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1

    		 Human Sf9 insect cells
    The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UbcH6/UBE2E1 Protein, Human (Sf9, His, Strep) is 192 a.a., .
  • HY-P701408
    USP10 Protein, Human

    USP10; Ubiquitin carboxyl-terminal hydrolase 10; DeUbiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10

    		 Human E. coli
    USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human is the recombinant human-derived USP10 protein, expressed by E. coli , with tag free. The total length of USP10 Protein, Human is 797 a.a., .
  • HY-P701417
    USP44 Protein, Human

    USP44; Ubiquitin carboxyl-terminal hydrolase 44; DeUbiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44

    		 Human E. coli
    The USP44 protein is a key deubiquitinase that regulates the spindle assembly checkpoint and prevents premature initiation of anaphase by deubiquitinating CDC20. This stabilizes the MAD2L1-CDC20-APC/C complex and enhances the spindle assembly checkpoint. USP44 Protein, Human is the recombinant human-derived USP44 protein, expressed by E. coli , with tag free. The total length of USP44 Protein, Human is 712 a.a., .
  • HY-P701419
    USP46 Protein, Human

    USP46; Ubiquitin carboxyl-terminal hydrolase 46; DeUbiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46

    		 Human E. coli
    USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free. The total length of USP46 Protein, Human is 366 a.a., .
  • HY-P701441
    USP21 Protein, Human

    USP21; Ubiquitin carboxyl-terminal hydrolase 21; DeUbiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21

    		 Human E. coli
    USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human is the recombinant human-derived USP21 protein, expressed by E. coli , with tag free. The total length of USP21 Protein, Human is 564 a.a., .
  • HY-P71403
    UBE2I Protein, Human (GST)

    SUMO-Conjugating Enzyme UBC9; SUMO-Protein Ligase; Ubiquitin Carrier Protein 9; Ubiquitin Carrier Protein I; Ubiquitin-Conjugating Enzyme E2 I; Ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9

    		 Human E. coli
    UBE2I Protein, a key participant in protein sumoylation, accepts ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4, and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex. Teaming up with E3 ligases like RANBP2, CBX4, and ZNF451, UBE2I catalyzes the covalent attachment of these SUMO proteins to target proteins, including critical substrates FOXL2 and KAT5. Its enzymatic activity extends to forming poly-SUMO chains, influencing diverse cellular processes and playing a pivotal role in specific protein modifications, such as sumoylation of p53/TP53 at 'Lys-386' and ERCC6. UBE2I Protein, Human (GST) is the recombinant human-derived UBE2I protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2I Protein, Human (GST) is 158 a.a., with molecular weight of ~40.0 kDa.
  • HY-P71407
    UBE2R2 Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 R2; Ubiquitin Carrier Protein R2; Ubiquitin-Conjugating Enzyme E2-CDC34B; Ubiquitin-Protein Ligase R2; UBE2R2; CDC34B; UBC3B

    		 Human E. coli
    UBE2R2 Protein, a key element in the ubiquitin-proteasome system, operates as an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to diverse protein substrates. In vitro, UBE2R2 displays versatile catalytic activity, facilitating both monoubiquitination and 'Lys-48'-linked polyubiquitination reactions. This implies its potential involvement in various cellular processes, including the targeted degradation of proteins, suggesting a role in the regulation of substrates like katenin. UBE2R2 Protein, Human (His) is the recombinant human-derived UBE2R2 protein, expressed by E. coli, with N-6*His labeled tag. The total length of UBE2R2 Protein, Human (His) is 238 a.a., with molecular weight of ~37.0 kDa.
  • HY-P701434
    USP9Y Protein, Human

    USP9Y; Probable Ubiquitin carboxyl-terminal hydrolase FAF-Y; DeUbiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; Ubiquitin thioesterase FAF-Y; Ubiquitin-specific protease 9; Y chromosome; Ubiquitin-specific-processing protease FAF-Y

    		 Human E. coli
    The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free. The total length of USP9Y Protein, Human is 420 a.a., .
  • HY-P76119
    UCHL3 Protein, Mouse (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3

    		 Mouse E. coli
    UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is involved in the regulation of cellular processes and protein degradation. It is particularly expressed in the testes and plays a vital role in spermatogenesis. UCHL3 Protein's significance in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Mouse (His) is the recombinant mouse-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Mouse (His) is 229 a.a., with molecular weight of ~30 kDa.
  • HY-P76689
    UCHL3 Protein, Rat (His)

    Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; Ubiquitin thioesterase L3

    		 Rat E. coli
    The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Rat (His) is 229 a.a., with molecular weight of ~28 kDa.
  • HY-P70998
    UBE2D3 Protein, Human
    1 Publications Verification

    Ubiquitin-conjugating enzyme E2 D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.

    		 Human E. coli
    Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) is an E3 ubiquitin protein ligase. UBE2D3 is able to accept ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfer it to substrates, often promoting its degradation by the proteasome. UBE2D3 Protein, Human is the recombinant human-derived UBE2D3 protein, expressed by E. coli , with tag free. The total length of UBE2D3 Protein, Human is 147 a.a., with molecular weight of ~15.0 kDa.
  • HY-P71409
    UBE2T Protein, Human (His)

    Ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; UBE2T

    		 Human E. coli
    UBE2T Protein, an essential ubiquitination component, serves as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to proteins. This multifaceted enzyme catalyzes monoubiquitination, crucial in MMC-induced DNA repair processes. Its significance is highlighted by specific association with the Fanconi anemia complex, collaborating with FANCL for FANCD2 monoubiquitination in the DNA damage response pathway. Beyond DNA repair, UBE2T mediates monoubiquitination of FANCL and FANCI and potentially contributes to BRCA1 ubiquitination and degradation. In vitro, UBE2T promotes various polyubiquitination types, showcasing involvement in diverse ubiquitin-dependent processes. UBE2T Protein, Human (His) is the recombinant human-derived UBE2T protein, expressed by E. coli, with N-6*His labeled tag. The total length of UBE2T Protein, Human (His) is 197 a.a., with molecular weight of 25-30 kDa.
  • HY-P701416
    USP44 Protein, Human (GST)

    USP44; Ubiquitin carboxyl-terminal hydrolase 44; DeUbiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44

    		 Human E. coli
    The USP44 protein is a key deubiquitinase that regulates the spindle assembly checkpoint and prevents premature initiation of anaphase by deubiquitinating CDC20. This stabilizes the MAD2L1-CDC20-APC/C complex and enhances the spindle assembly checkpoint. USP44 Protein, Human (GST) is the recombinant human-derived USP44 protein, expressed by E. coli , with N-GST labeled tag. The total length of USP44 Protein, Human (GST) is 712 a.a., .
  • HY-P701442
    USP21 Protein, Human (GST)

    USP21; Ubiquitin carboxyl-terminal hydrolase 21; DeUbiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21

    		 Human E. coli
    USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human (GST) is the recombinant human-derived USP21 protein, expressed by E. coli , with N-GST labeled tag. The total length of USP21 Protein, Human (GST) is 564 a.a., .
  • HY-P71398
    UBE2B Protein, Human (HEK293, His)

    Ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; Ubiquitin Carrier Protein B; Ubiquitin-Conjugating Enzyme E2-17 kDa; Ubiquitin-Protein Ligase B; UBE2B; RAD6B

    		 Human HEK293
    UBE2B Protein, a key ubiquitination player, functions as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing covalent attachment to proteins. Teaming with BRE1 (RNF20 and/or RNF40) E3 enzyme, UBE2B plays a pivotal role in transcriptional regulation by catalyzing histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). This modification tags various epigenetic processes and is essential for H3K4me and H3K79me formation. UBE2B exhibits versatile ubiquitin chain linkages, mediating 'Lys-11', 'Lys-48', and 'Lys-63'-linked polyubiquitination in vitro. It also plays a crucial role in postreplication repair of UV-damaged DNA, forming the UBE2B-RAD18 ubiquitin ligase complex with RAD18 E3 ligase, which mono-ubiquitinates DNA-associated PCNA on 'Lys-164'. The diverse functions of UBE2B suggest potential involvement in neurite outgrowth. UBE2B Protein, Human (HEK293, His) is the recombinant human-derived UBE2B protein, expressed by HEK293, with C-6*His labeled tag. The total length of UBE2B Protein, Human (HEK293, His) is 152 a.a., with molecular weight of ~17.0 kDa.
  • HY-P701433
    USP9Y Protein, Human (GST)

    USP9Y; Probable Ubiquitin carboxyl-terminal hydrolase FAF-Y; DeUbiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; Ubiquitin thioesterase FAF-Y; Ubiquitin-specific protease 9; Y chromosome; Ubiquitin-specific-processing protease FAF-Y

    		 Human E. coli
    The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human (GST) is the recombinant human-derived USP9Y protein, expressed by E. coli , with N-GST labeled tag. The total length of USP9Y Protein, Human (GST) is 420 a.a., .
  • HY-P71418
    USP14 Protein, Human (His)
    1 Publications Verification

    Ubiquitin Carboxyl-Terminal Hydrolase 14; DeUbiquitinating Enzyme 14; Ubiquitin Thioesterase 14; Ubiquitin-Specific-Processing Protease 14; USP14; TGT

    		 Human E. coli
    USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag. The total length of USP14 Protein, Human (His) is 404 a.a., with molecular weight of 47-52 kDa.
  • HY-P701418
    USP46 Protein, Human (His, GST)

    USP46; Ubiquitin carboxyl-terminal hydrolase 46; DeUbiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46

    		 Human E. coli
    USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag. The total length of USP46 Protein, Human (His, GST) is 366 a.a., .
  • HY-P701426
    USP51 Protein, Human (Sf9)

    USP51; Ubiquitin carboxyl-terminal hydrolase 51; DeUbiquitinating enzyme 51; Ubiquitin thioesterase 51; Ubiquitin-specific-processing protease 51

    		 Human Sf9 insect cells
    The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (Sf9) is the recombinant human-derived USP51 protein, expressed by Sf9 insect cells , with tag free. The total length of USP51 Protein, Human (Sf9) is 344 a.a., .
  • HY-P701443
    USP22 Protein, Human (Sf9)

    USP22; Ubiquitin carboxyl-terminal hydrolase 22; DeUbiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22

    		 Human Sf9 insect cells
    USP22 protein is a histone deubiquitinating enzyme in the SAGA complex that catalyzes the deubiquitination of histones H2A and H2B and acts as a coactivator. Activators such as MYC facilitate its recruitment to gene promoters, which is critical for transcriptional activation. USP22 Protein, Human (Sf9) is the recombinant human-derived USP22 protein, expressed by Sf9 insect cells , with tag free. The total length of USP22 Protein, Human (Sf9) is 524 a.a., .
  • HY-P701446
    USP28 Protein, Human (Sf9)

    USP28; Ubiquitin carboxyl-terminal hydrolase 28; DeUbiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28

    		 Human Sf9 insect cells
    The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (Sf9) is the recombinant human-derived USP28 protein, expressed by Sf9 insect cells , with tag free. The total length of USP28 Protein, Human (Sf9) is 1076 a.a., .
  • HY-P701448
    USP29 Protein, Human (Sf9)

    USP29; Ubiquitin carboxyl-terminal hydrolase 29; DeUbiquitinating enzyme 29; Ubiquitin thioesterase 29; Ubiquitin-specific-processing protease 29

    		 Human Sf9 insect cells
    USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (Sf9) is the recombinant human-derived USP29 protein, expressed by Sf9 insect cells , with tag free. The total length of USP29 Protein, Human (Sf9) is 921 a.a., .
  • HY-P701454
    USP37 Protein, Human (Sf9)

    USP37; Ubiquitin carboxyl-terminal hydrolase 37; DeUbiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37

    		 Human Sf9 insect cells
    The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (Sf9) is the recombinant human-derived USP37 protein, expressed by Sf9 insect cells , with tag free. The total length of USP37 Protein, Human (Sf9) is 978 a.a., .
  • HY-P702063
    USP11 Protein, Human (Sf9)

    USP11; Ubiquitin carboxyl-terminal hydrolase 11; DeUbiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11

    		 Human Sf9 insect cells
    The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (Sf9) is the recombinant human-derived USP11 protein, expressed by Sf9 insect cells , with tag free. The total length of USP11 Protein, Human (Sf9) is 962 a.a., .
  • HY-P702565
    USP10 Protein, Human (Sf9)

    USP10; Ubiquitin carboxyl-terminal hydrolase 10; DeUbiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10

    		 Human Sf9 insect cells
    USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (Sf9) is the recombinant human-derived USP10 protein, expressed by Sf9 insect cells , with tag free. The total length of USP10 Protein, Human (Sf9) is 797 a.a., with molecular weight of 87.2 kDa.

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