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Results for "

VCP/p97

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p97 (6)
By Research Areas:	Cancer (7)

7

Inhibitors & Agonists

3

Recombinant Proteins

1

Antibodies

Targets Recommended: p97

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CB-5083 10+ Cited Publications	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the **p97 AAA ATPase*/VCP*. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM 。

HY-15713

NMS-873

5+ Cited Publications

p97 Cancer

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC₅₀ value of 30 nM.

VCP/p97 inhibitor-1	p97	Cancer
VCP/p97 inhibitor-1 is a potent inhibitor of *VCP/p97* (also called Cdc48, CDC-. 48, or Ter94) with an IC₅₀ of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS) .

NPD8733	Others	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

NW 1028	p97	Cancer
NW 1028 is a potent *VCP/p97* inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with K_d values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells .

MSC1094308	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and *p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97*. MSC1094308 can be used in study of cancer .

NMS-859	p97	Cancer
NMS-859 is a potent, covalent **VCP (p97) inhibitor, with IC₅₀*s of 0.37 and 0.36 μM for wild-type VCP* in the presence of 60 μM and 1 mM ATP in cells, respectively.

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	VCP Protein, Human (His) Transitional Endoplasmic Reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 Subunit; Valosin-Containing Protein; VCP	Human	E. coli
	VCP proteins are indispensable for Golgi stack dynamics, coordinating fragmentation during mitosis and postmitotic reorganization. It actively promotes the formation of the transitional endoplasmic reticulum (tER), enables ATP-dependent vesicle budding, and enables membrane transfer to the Golgi apparatus. VCP Protein, Human (His) is the recombinant human-derived VCP protein, expressed by E. coli , with C-6*His labeled tag. The total length of VCP Protein, Human (His) is 588 a.a., with molecular weight of ~75.0 kDa.

	VCPIP1 Protein, Human (Sf9) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (Sf9) is the recombinant human-derived VCPIP1 protein, expressed by Sf9 insect cells , with tag free. The total length of VCPIP1 Protein, Human (Sf9) is 1222 a.a., .

	VCPIP1 Protein, Human (Sf9, His) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (Sf9, His) is the recombinant human-derived VCPIP1 protein, expressed by Sf9 insect cells , with C-8*His labeled tag. The total length of VCPIP1 Protein, Human (Sf9, His) is 1222 a.a., .

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