Search Result

Search Result

Results for "

VEGF-C

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) ERK (1) Small Interfering RNA (siRNA) (1) VEGFR (6)
By Research Areas:	Cancer (5) Cardiovascular Disease (1)

8

Inhibitors & Agonists

3

Inhibitory Antibodies

7

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ramucirumab 2 Publications Verification	VEGFR	Cancer
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab is also an angiogenesis inhibitor .

Ramucirumab (anti-VEGFR)	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

MAZ51 2 Publications Verification	VEGFR Apoptosis	Cancer
MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity .

VEGFR-3-IN-1	VEGFR	Cancer
VEGFR-3-IN-1 is a potent and selective VEGFR3 inhibitor with an IC₅₀ of 110.4 nM. VEGFR-3-IN-1 significantly inhibits proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells by inactivating the VEGFR3 signaling pathway, and also effectively inhibits breast cancer growth .

VEGFC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VEGFC Human Pre-designed siRNA Set A VEGFC Human Pre-designed siRNA Set A

Deoxyshikonin 1 Publications Verification
Deoxyshikonin increases the expression of *VEGF-C* and *VEGF-A* mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .

Sozinibercept OPT 302; VGX-300	VEGFR	Cardiovascular Disease
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of *VEGF-C/D*, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats .

EVT801	VEGFR ERK	Cancer
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC₅₀=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Recombinant Proteins Recommended:

VEGF-C

Species:	Human (5) Mouse (2) Rat (2)
Tag:	His (5) Tag Free (1) Avi (2) Fc (1)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

	VEGF-C Protein, Human (HEK293, His-Avi) VEGFC; VEGF-CC; VEGFc; Flt4-L; VRP	Human	HEK293
	VEGF-C Protein, a crucial member of the PDGF/VEGF growth factor family, plays a role in vital cellular signaling pathways. As part of this family, VEGF-C likely shares characteristics with related proteins, promoting cell growth, angiogenesis, and lymphangiogenesis. Membership in the PDGF/VEGF growth factor family underscores its role in vascular and lymphatic development regulation. Studying VEGF-C enhances understanding of its functions, potential therapeutic applications, and impact on tissue development. Further exploration can deepen comprehension of VEGF-C's contribution to physiological and pathological conditions. VEGF-C Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of VEGF-C Protein, Human (HEK293, His-Avi) is 125 a.a., with homodimer molecular weight of ~23-30 kDa.

	VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) VEGFC; VEGF-CC; VEGFc; Flt4-L; VRP	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is 125 a.a., with homodimer molecular weight of ~23-30 kDa.

	VEGF-CC Protein, Human (196a.a, HEK293, His) Vascular Endothelial Growth Factor C; VEGF-C; Flt4 Ligand; Flt4-L; Vascular Endothelial Growth Factor-Related Protein; VRP; VEGFC	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (196a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-CC Protein, Human (196a.a, HEK293, His) is 196 a.a., with molecular weight of 25-30 kDa.

	VEGF-CC Protein, Mouse/Rat (HEK293, His) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Mouse;Rat	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, His) is the recombinant mouse, rat-derived VEGF-CC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-CC Protein, Mouse/Rat (HEK293, His) is 116 a.a., with molecular weight of 14-23 kDa.

	VEGF-CC Protein, Mouse/Rat (HEK293, Fc) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Rat;Mouse	HEK293
	VEGF-CC protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is the recombinant rat, mouse-derived VEGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-CC Protein, Mouse/Rat (HEK293, Fc) is 116 a.a., with molecular weight of ~44 & 34 kDa, respectively.

	VEGF-CC Protein, Human (125a.a, HEK293, His) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Human	HEK293
	The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-CC Protein, Human (125a.a, HEK293, His) is the recombinant human-derived VEGF-CC protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGF-CC Protein, Human (125a.a, HEK293, His) is 125 a.a., with molecular weight of ~22.5 kDa.

	VEGF-CC Protein, Human (116a.a, HEK293) rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP	Human	HEK293
	VEGF-C Protein, Human (116a.a, HEK293) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

MedChemExpress Magic Cece

MedChemExpress: Contact Us; About Us; Headquarters; Distributors; Statement on False Report; Careers

Customer Support: Technical Support; Service; Ordering Information; Easy Return; Shipping Rates & Policies; Intellectual Property Promise

Resources: Free Sample; Resources; Molarity Calculator; Dilution Calculator; Terms & Conditions; Reconstitution Calculator; Specific Activity Calculator

Subscribe to our E-newsletter

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.

Copyright © 2013-2024 MedChemExpress. All Rights Reserved.: Site Map Privacy Policy

Join with us